Explanipedia

Development of Protein‐Loaded Layer‐by‐Layer Capsules Using Mesoporous Silica Particle Templates Open

Stefan Wagner, Martin Gericke, Thomas Heinze, Lars Dähne · 2025

This study explores protein‐loaded, semipermeable polymer capsules for potential applications in drug delivery and biomedical analytics. Several proteins were loaded into mesoporous silica particles and encapsulated by layer‐by‐layer (LbL)…

Quantitative Investigation of Layer-by-Layer Deposition and Dissolution Kinetics by New Label-Free Analytics Based on Low-Q-Whispering Gallery Modes Open

Mateusz Olszyna, Algi Domaç, J. Zimmer, Lars Dähne · 2024

A new instrument for label-free measurements based on optical Low-Q Whispering Gallery Modes (WGMs) for various applications is used for a detailed study of the deposition and release of Layer-by-Layer polymer coatings. The two selected co…

Symmetric and asymmetric ceramic-supported polyelectrolyte multilayer nanofiltration membranes Open

Robert Niestroj-Pahl, Esra te Brinke, Hannah Roth, Lars Dähne, Wiebe M. de Vos · 2024

Fluorescence Label‐Free Doxorubicin Sensor Using Polystyrene Sulfonate as a Synthetic Receptor in Whispering Gallery Mode Microresonators Open

Elena Maurina, Algi Domaç, Mateusz Olszyna, Lars Dähne, Giuseppe Barillaro · 2024

The conventional quantification of Doxorubicin (DXR), a crucial anticancer drug, typically relies on complex and expensive techniques, limiting measurements beyond hospital settings and at different time intervals. Here, a label‐free fluor…

Layer-by-Layer Assembling and Capsule Formation of Polysaccharide-Based Polyelectrolytes Studied by Whispering Gallery Mode Experiments and Confocal Laser Scanning Microscopy Open

Stefan Wagner, Mateusz Olszyna, Algi Domaç, Thomas Heinze, Martin Gericke , et al. · 2024

The layer-by-layer (LbL) assembling of oppositely charged polyelectrolytes was studied using semi-synthetic polysaccharide derivatives, namely the polycations 6-aminoethylamino-6-deoxy cellulose (ADC) and cellulose (2-(ethylamino)ethylcarb…

Design of Vaterite Nanoparticles for Controlled Delivery of Active Immunotherapeutic Proteins Open

Levi Collin Nelemans, Ghizlane Choukrani, Natasha Ustyanovska‐Avtenyuk, Valerie R. Wiersma, Lars Dähne , et al. · 2024

Despite clinical advances in immunotherapy, still many therapeutics cause dose‐limiting (auto)immune‐mediated toxicities. Nanoparticle‐based drug delivery systems (DDS) can improve cancer immunotherapy through site‐specific delivery and co…

Direct Functionalization of Polysaccharide‐Based Xylan Phenyl Carbonate Nanoparticles with Tumor Cell Specific Antibodies Open

Vrouyr Bilemjian, Yusheng Lin, Wei Wan, Gabriella Egri, Gerwin Huls , et al. · 2024

An efficient and easy‐to‐use approach is presented for obtaining biocompatible polysaccharide‐based nanoparticles (NP) that can act as tumor‐specific drug delivery agents. Two antibodies are directly immobilized onto reactive xylan phenyl …

Mechanically induced dye-release from polyurea microcapsules in a rubbery adhesive Open

C.C. Koch, Anke-Susanne Müller, Martin Kahlmeyer, Tino Riske, Inga Melnyk , et al. · 2023

Especially in the building industry the demand for in situ monitoring concepts of adhesive joints persists. In a new approach, microcapsules filled with special dyes, are added into a rubbery adhesive. Certain stress levels within the adhe…

Implantable and Bioresorbable Nanostructured Fluorescence Sensor for In vivo pH Monitoring Open

Martina Corsi, Alessandro Paghi, Stefano Mariani, Giulia Golinelli, Aline Debrassi , et al. · 2022

Here we report on a bioresorbable fluorescence sensor for in vivo pH monitoring. The sensor leverages a nanometer-thick multilayer stack of polyelectrolytes labelled with a pH-insensitive fluorophore conformably deposited within a porous s…

Operation of Hybrid Membranes for the Removal of Pharmaceuticals and Pollutants from Water and Wastewater Open

Mónica Vergara‐Araya, Henning Oeltze, Jenny Radeva, Anke G. Roth, Christian Göbbert , et al. · 2022

Hybrid ceramic membranes (i.e., membranes with a layer-by-layer (LbL) coating) are an emerging technology to remove diverse kinds of micropollutants from water. Hybrid ceramic membranes were tested under laboratory conditions as single-cha…

Glycopolymer Based LbL Multilayer Thin Films with Embedded Liposomes Open

Jo Sing Julia Tang, Aline Debrassi Smaczniak, Lucas Tepper, Sophia Rosencrantz, Mina Aleksanyan , et al. · 2022

Layer‐by‐layer (LbL) self‐assembly emerged as an efficient technique for fabricating coating systems for, e.g., drug delivery systems with great versatility and control. In this work, protecting group free and aqueous‐based syntheses of bi…

Nanoscale Photoluminescence Manipulation in Monolithic Porous Silicon Oxide Microcavity Coated with Rhodamine‐Labeled Polyelectrolyte via Electrostatic Nanoassembling Open

Zhi Chen, Valentina Robbiano, Giuseppe M. Paternò, Giuseppe Carnicella, Aline Debrassi , et al. · 2021

Porous silicon (PSi) is a promising material for future integrated nanophotonics when coupled with guest emitters, still facing challenges in terms of homogenous distribution and nanometric thickness of the emitter coating within the silic…

Whispering Gallery Modes-based biosensors for real-time monitoring and binding characterization of antibody-based cancer immunotherapeutics Open

Jimena Álvarez Freile, Ghizlane Choukrani, Kerstin Zimmermann, Edwin Bremer, Lars Dähne · 2021

Development of novel protein-based drugs such as antibodies or immunocytokines and initial validation of target binding typically occurs in 2D settings with e.g., surface plasmon resonance or reflection interferometry using antigen-coated …

High Loading Efficiency and Controlled Release of Bioactive Immunotherapeutic Proteins Using Vaterite Nanoparticles (Part. Part. Syst. Charact. 7/2021) Open

Ghizlane Choukrani, Jimena Álvarez Freile, Natasha Ustyanovska Avtenyuk, Wei Wan, Kerstin Zimmermann , et al. · 2021

In article 2100012, Dähne and co-workers provide a framework for the development of a vaterite-based drug delivery system as a carrier for bioactive protein-based cancer therapeutics. In addition, a system to mimic (pH) conditions under bo…

High Loading Efficiency and Controlled Release of Bioactive Immunotherapeutic Proteins Using Vaterite Nanoparticles Open

Ghizlane Choukrani, Jimena Álvarez Freile, Natasha Ustyanovska Avtenyuk, Wei Wan, Kerstin Zimmermann , et al. · 2021

Nanoparticles may limit off‐tumor/on‐target ubiquitous activation of signaling by protein‐based drugs. However, many challenges still exist in the design of a nanoparticle for protein delivery. In this study, conditions to establish vateri…

Hybrid Ceramic Membranes for the Removal of Pharmaceuticals from Aqueous Solutions Open

Jenny Radeva, Anke G. Roth, Christian Göbbert, Robert Niestroj-Pahl, Lars Dähne , et al. · 2021

Layer-by-Layer (LbL) technology was used to coat alumina ceramic membranes with nanosized polyelectrolyte films. The polyelectrolyte chains form a network with nanopores on the ceramic surface and promote the rejection of small molecules s…

Performance of Layer-by-Layer-Modified Multibore® Ultrafiltration Capillary Membranes for Salt Retention and Removal of Antibiotic Resistance Genes Open

Robert Niestroj-Pahl, Lara Stelmaszyk, Ibrahim M. A. ElSherbiny, Hussein Abuelgasim, Michaela Krug , et al. · 2020

Polyether sulfone Multibore® ultrafiltration membranes were modified using polyelectrolyte multilayers via the layer-by-layer (LbL) technique in order to increase their rejection capabilities towards salts and antibiotic resistance genes. …

Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles Open

Dennis Kaden, Lars Dähne, Fanny Knorr, Heike Richter, Jürgen Lademann , et al. · 2020

Nanoparticles can be applied to the hair follicles, which can serve as reservoirs for triggered drug release. A valid measurement method for the determination of the pH within the hair follicle in vivo has not been shown yet. Here, melamin…

Facing the Challenges of Pharmaceutical Research Using Whispering Gallery Modes-Based Biosensors Open

Lars Dähne · 2020

During the last decade, different Whispering Gallery Modes-based biosensors (WGMS) have been proposed as bioanalytical platforms. These systems allow for a label-free real-time monitoring of a wide range of molecules, including DNA, protei…

Decoration of Porous Silicon with Gold Nanoparticles via Layer-by-Layer Nanoassembly for Interferometric and Hybrid Photonic/Plasmonic (Bio)sensing Open

Stefano Mariani, Alessandro Paghi, Antonino A. La Mattina, Aline Debrassi, Lars Dähne , et al. · 2019

Gold nanoparticle layers (AuNPLs) enable the coupling of morphological, optical, and electrical properties of gold nanoparticles (AuNPs) with tailored and specific surface topography, making them exploitable in many bioapplications (e.g., …

Polymer Fibers Covered by Soft Multilayered Films for Sensing Applications in Composite Materials Open

Dorian Nikoniuk, Karolina Bednarska, Maksymilian Sienkiewicz, G. Krzesiński, Mateusz Olszyna , et al. · 2019

This paper presents the possibility of applying a soft polymer coating by means of a layer-by-layer (LbL) technique to highly birefringent polymer optical fibers designed for laminating in composite materials. In contrast to optical fibers…

The Future of Layer-by-Layer Assembly: A Tribute to <i>ACS Nano</i> Associate Editor Helmuth Möhwald Open

Shuang Zhao, Frank Caruso, Lars Dähne, Gero Decher, Bruno G. De Geest , et al. · 2019

Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the memory of ACS Nano associate editor Prof. Dr. Helmuth Möhwald, we discuss the developments and applications t…

Controlled release of nisin from Neusilin particles to enhance food safety of sour curd cheese Open

Maik Szendy, Florian Westhaeuser, Barbara Baude, Jessica Reim, Lars Dähne , et al. · 2019

Virosome engineering of colloidal particles and surfaces: bioinspired fusion to supported lipid layers Open

Jana Fleddermann, Eleftheria Diamanti, Stavros Azinas, Marija Košutić, Lars Dähne , et al. · 2016

Inmunostimulating reconstituted influenza virosomes (IRIVs), liposomes with functional viral envelop glycoproteins, fuse on supported lipid bilayers with a pH dependent mechanism, in analogy to the virus fusion on cell membranes.

Tailored Surface Engineering of Pigments by Layer-by-Layer Coating Open

Lars Dähne, Julia Schneider, Dirk Lewe, Henrik Petersen · 2015

We have evaluated the feasibility of layer-by-layer encapsulation technology for the improvement of dye pigments used for tattoos or permanent make-up. The formation of core-shell structures is possible by coating pigments with thin films …

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