Lars Devisscher
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View article: Tozasertib Analogues as Inhibitors of Necroptotic Cell Death
Tozasertib Analogues as Inhibitors of Necroptotic Cell Death Open
Receptor interacting protein kinase 1 (RIPK1) plays a crucial role in tumor necrosis factor (TNF)-induced necroptosis, suggesting that this pathway might be druggable. Most inhibitors of RIPK1 are classified as either type II or type III k…
View article: RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680) Open
The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are …