Lars Eijssen
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View article: Differential susceptibility to prenatal stress exposure in serotonin transporter-deficient female mice—an epigenetic exploration
Differential susceptibility to prenatal stress exposure in serotonin transporter-deficient female mice—an epigenetic exploration Open
Introduction Early-life stress exposure has been linked to an increased risk for the onset of mental disorders. As another factor, an individual’s genetic make-up may also tip the scale towards health or disease, with certain genetic varia…
View article: Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures
Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures Open
Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late onset Alzheimer’s disease (LOAD) contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subty…
View article: Integrative analysis of 115 transcriptomic studies decodes the molecular landscape of neurodevelopmental disorders
Integrative analysis of 115 transcriptomic studies decodes the molecular landscape of neurodevelopmental disorders Open
View article: The inconclusive superiority debate of allogeneic versus autologous MSCs in treating patients with HFrEF: a systematic review and meta-analysis of RCTs
The inconclusive superiority debate of allogeneic versus autologous MSCs in treating patients with HFrEF: a systematic review and meta-analysis of RCTs Open
View article: Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures
Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures Open
Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late-onset Alzheimer’s disease contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subtyping th…
View article: Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids
Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids Open
Rett syndrome (RTT) is a neurodevelopmental disorder caused by de novo mutations in the MECP2 gene. Although miRNAs in extracellular vesicles (EVs) have been suggested to play an essential role in several neurological conditions, no prior …
View article: Blood‐based multivariate methylation risk score for cognitive impairment and dementia
Blood‐based multivariate methylation risk score for cognitive impairment and dementia Open
INTRODUCTION The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator of lifestyle and environmental influences, positions blood‐derived DNA methylation as a promis…
View article: A novel insight into neurological disorders through HDAC6 protein–protein interactions
A novel insight into neurological disorders through HDAC6 protein–protein interactions Open
View article: Dose-response relationship of MSCs as living Bio-drugs in HFrEF patients: a systematic review and meta-analysis of RCTs
Dose-response relationship of MSCs as living Bio-drugs in HFrEF patients: a systematic review and meta-analysis of RCTs Open
View article: A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis
A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis Open
Human mesenchymal stem cells (hMSCs) are widely used to model osteogenic differentiation in vitro, yet few studies compare the numerous available protocols. The poor translation between in vitro and in vivo results in bone regeneration hig…
View article: Methylomic‐based molecular subtyping of late onset Alzheimer’s Disease
Methylomic‐based molecular subtyping of late onset Alzheimer’s Disease Open
Background Accumulating evidence shows that the heterogeneity and temporal complexity of Alzheimer’s Disease contribute to the treatment failure. Advances in omics technologies along with development of efficient integrative analytical pip…
View article: Multiomics‐based prediction of trajectories of global cognitive functioning in the ADNI cohort
Multiomics‐based prediction of trajectories of global cognitive functioning in the ADNI cohort Open
Background Cognitive impairment is the first manifestation of dementia. However, the rate of changes in cognitive function varies between individuals and unraveling heterogeneity in the trajectory of cognitive decline and dementia is cruci…
View article: Blood-based multivariate methylation risk score for cognitive impairment and dementia
Blood-based multivariate methylation risk score for cognitive impairment and dementia Open
INTRODUCTION Given the established association between DNA methylation and the pathophysiology of dementia and its plausible role as a molecular mediator of lifestyle and environment, blood-derived DNA methylation data could enable early d…
View article: To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers
To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers Open
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling condition resulting in a reduced quality of life and increased economic burden. The disorder is directly related to exposure to a traumatic event, e.g., a re…
View article: Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease
Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease Open
View article: Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression
Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression Open
View article: A Public Health Perspective of Post-Traumatic Stress Disorder
A Public Health Perspective of Post-Traumatic Stress Disorder Open
Trauma exposure is one of the most important and prevalent risk factors for mental and physical ill-health. Prolonged or excessive stress exposure increases the risk of a wide variety of mental and physical symptoms, resulting in a conditi…
View article: A systematically derived overview of the non-ubiquitous pathways and genes that define the molecular and genetic signature of the healthy trabecular meshwork
A systematically derived overview of the non-ubiquitous pathways and genes that define the molecular and genetic signature of the healthy trabecular meshwork Open
View article: Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease
Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease Open
Cognitive impairment is a debilitating symptom in Parkinson’s disease (PD). We aimed to establish an accurate multivariate machine learning (ML) model to predict cognitive outcome in newly diagnosed PD cases from the Parkinson’s Progressio…
View article: Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease
Machine learning-based prediction of cognitive outcomes in de novo Parkinson's disease Open
Cognitive impairment is a debilitating symptom in Parkinson’s disease (PD). We aimed to establish an accurate multivariate machine learning (ML) model to predict cognitive outcome in newly diagnosed PD cases from the Parkinson’s Progressio…
View article: Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open
View article: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open
View article: The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics
The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics Open
Exposure to trauma is one of the most important and prevalent risk factors for mental and physical ill-health. Excessive or prolonged stress exposure increases the risk of a wide variety of mental and physical symptoms. However, people dif…
View article: COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms Open
View article: Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility
Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility Open
View article: Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach
Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach Open
View article: Integrated analysis of human transcriptome data for Rett syndrome finds a network of involved genes
Integrated analysis of human transcriptome data for Rett syndrome finds a network of involved genes Open
Rett syndrome (RTT) is a rare disorder causing severe intellectual and physical disability. The cause is a mutation in the gene coding for the methyl-CpG binding protein 2 (MECP2), a multifunctional regulator protein. Purpose of the study …
View article: COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms
COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms Open
We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the dis…
View article: Aqueous humor proteome of primary open angle glaucoma: A combined dataset of mass spectrometry studies
Aqueous humor proteome of primary open angle glaucoma: A combined dataset of mass spectrometry studies Open
View article: Comparative proteomic analysis of human mesenchymal stromal cell behavior on calcium phosphate ceramics with different osteoinductive potential
Comparative proteomic analysis of human mesenchymal stromal cell behavior on calcium phosphate ceramics with different osteoinductive potential Open