Lars Etholm
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View article: Predictive encoding of auditory sequences in the human prefrontal cortex
Predictive encoding of auditory sequences in the human prefrontal cortex Open
Humans extract regularities from the environment to form expectations that guide perception and optimize behavior. Although the prefrontal cortex (PFC) is central to this process, the relative contributions of orbitofrontal (OFC) and later…
View article: Localizing value of disturbances of self‐integration, depersonalization, and forced thinking: A <scp>systematic review</scp>
Localizing value of disturbances of self‐integration, depersonalization, and forced thinking: A <span>systematic review</span> Open
We performed a systematic review of the localizational value of disturbances of self‐integration, depersonalization and forced thinking in focal epilepsy with the aim to summarize the state‐of‐the‐art anatomo‐clinical correlations in the f…
View article: Sensitivity and specificity of the Salzburg EEG criteria for nonconvulsive status epilepticus
Sensitivity and specificity of the Salzburg EEG criteria for nonconvulsive status epilepticus Open
Objective The Salzburg EEG criteria for nonconvulsive status epilepticus (NCSE) have been proposed as consensus criteria for NCSE. We aimed to perform an independent study of their diagnostic accuracy. Methods A prospective study was carri…
View article: JS05.6.A CONTINUOUS DYNAMIC MAPPING OF LANGUAGE FUNCTION AND COGNITIVE CONTROL AND SPATIAL CORRELATION TO WHITE MATTER TRACTS USING INTRAOPERATIVE MRI TRACTOGRAPHY
JS05.6.A CONTINUOUS DYNAMIC MAPPING OF LANGUAGE FUNCTION AND COGNITIVE CONTROL AND SPATIAL CORRELATION TO WHITE MATTER TRACTS USING INTRAOPERATIVE MRI TRACTOGRAPHY Open
BACKGROUND Subcortical mapping of white matter tracts (WMTs) subserving complex processes as movement, language and cognition is critical in glioma surgery. Continuous dynamic mapping (CDM) is an indispensable tool for mapping of the corti…
View article: Synapsin 2 regulates NCX1 trafficking and is down-regulated in the failing myocardium, which increases the risk of ventricular arrhythmia and heart failure mortality
Synapsin 2 regulates NCX1 trafficking and is down-regulated in the failing myocardium, which increases the risk of ventricular arrhythmia and heart failure mortality Open
Background Synapsin 2 (Syn2) modulates vesicle transport in the post-synaptic terminal in the brain, and has been linked to sudden unexplained death in epilepsy, but has never previously been studied in the myocardium. Purpose Given the as…
View article: Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis
Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis Open
We found neuron- and glia-specific changes in DNAm and gene expression in early epileptogenesis. We detected single genetic loci in several epilepsy-related genes, where DNAm and GE changes coincide, worth further investigation. Further, o…
View article: Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis
Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis Open
Introduction: Autonomic nervous system (ANS) symptoms are prevalent in multiple sclerosis (MS) as is neurodegeneration. Our aim was to explore the occurrence of ANS symptoms and retinal neurodegeneration in a newly diagnosed MS popu…
View article: Fatigue and cognition: Pupillary responses to problem‐solving in early multiple sclerosis patients
Fatigue and cognition: Pupillary responses to problem‐solving in early multiple sclerosis patients Open
Introduction In early multiple sclerosis ( MS ) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these sympt…
View article: Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis
Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis Open
RRMS patients have an increased SI time compared to controls. Cognitive tests results, exemplified by the wSDMT, may be confounded by eye and hand motor function.
View article: Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2
Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2 Open
Synapsins are pre-synaptic vesicle-associated proteins linked to the pathogenesis of epilepsy through genetic association studies in humans. Deletion of synapsins causes an excitatory/inhibitory imbalance, exemplified by the epileptic phen…