Lars Fugger
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View article: The spatiotemporal distribution of human pathogens in ancient Eurasia
The spatiotemporal distribution of human pathogens in ancient Eurasia Open
View article: Immune perturbation by the ileal microbiota in multiple sclerosis
Immune perturbation by the ileal microbiota in multiple sclerosis Open
View article: Genetic variation in<i>HIF1A</i>is associated with smoldering inflammation and disease progression in Multiple Sclerosis
Genetic variation in<i>HIF1A</i>is associated with smoldering inflammation and disease progression in Multiple Sclerosis Open
Background Understanding the mechanisms underlying disease progression in Multiple Sclerosis (MS) is fundamental to pave the way to treatment advances. Smoldering demyelinating inflammation characterized by iron deposition is observed at t…
View article: Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases Open
Antibodies can block immune receptor engagement or trigger the receptor machinery to initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RP…
View article: Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations Open
View article: The selection landscape and genetic legacy of ancient Eurasians
The selection landscape and genetic legacy of ancient Eurasians Open
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of…
View article: Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors
Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors Open
JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in treating complex diseases such as cancers and immune-mediated disorders. However, their broad reach also poses safety concerns, which have fuelled a…
View article: The spatiotemporal distribution of human pathogens in ancient Eurasia and the emergence of zoonotic diseases
The spatiotemporal distribution of human pathogens in ancient Eurasia and the emergence of zoonotic diseases Open
Summary Infectious diseases have had devastating impacts on human populations throughout history, but important questions about their origins and past dynamics remain 1 . To create the first archaeogenetic-based spatiotemporal map of human…
View article: Acute Inflammatory Diseases of the Central Nervous System After SARS-CoV-2 Vaccination
Acute Inflammatory Diseases of the Central Nervous System After SARS-CoV-2 Vaccination Open
ChAdOx1S was associated with 12/14 antibody-positive cases, the majority MOGAD. MOGAD patients presented atypically, only 2 with isolated ON (1 after BNT162b2 vaccine) but with frequent ADEM-like brain lesions and LETM. Within the seronega…
View article: Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populations
Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populations Open
SUMMARY Multiple sclerosis (MS) is a modern neuro-inflammatory and -degenerative disease, which is most prevalent in Northern Europe. Whilst it is known that inherited risk to MS is located within or within close proximity to immune genes,…
View article: Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade Open
View article: Epitope length variants balance protective immune responses and viral escape in HIV-1 infection
Epitope length variants balance protective immune responses and viral escape in HIV-1 infection Open
View article: Parental-fetal interplay of immune genes leads to intrauterine growth restriction
Parental-fetal interplay of immune genes leads to intrauterine growth restriction Open
Intrauterine growth restriction (IUGR) of fetuses affects 5-10% of pregnancies and is associated with perinatal morbidity, mortality and long-term health issues. Understanding genetic predisposition to IUGR is challenging, owing to extensi…
View article: Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis Open
This study was supported by funding from the University Medical Center Hamburg-Eppendorf, the Stifterverband für die Deutsche Wissenschaft, the OAK Foundation, Medical Research Council UK, and Wellcome.
View article: The spatial RNA integrity number assay for in situ evaluation of transcriptome quality
The spatial RNA integrity number assay for in situ evaluation of transcriptome quality Open
The RNA integrity number (RIN) is a frequently used quality metric to assess the completeness of rRNA, as a proxy for the corresponding mRNA in a tissue. Current methods operate at bulk resolution and provide a single average estimate for …
View article: Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes
Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes Open
We created a TCR transgenic mouse with CD4+ T cells recognizing the immunodominant DQ2.5-glia-ω2 gluten epitope. We show that these cells respond to deamidated gluten feed in vivo and compare them to previously published α2- and…
View article: Author response for "Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes"
Author response for "Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes" Open
View article: Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient
Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient Open
Approximately 200,000 multiple sclerosis (MS) patients worldwide receive B-cell-depleting immunotherapy with rituximab (anti-CD20), which eliminates the ability to generate an antibody response to new infections. As severe acute respirator…
View article: Inflammation-related plasma and CSF biomarkers for multiple sclerosis
Inflammation-related plasma and CSF biomarkers for multiple sclerosis Open
Effective biomarkers for multiple sclerosis diagnosis, assessment of prognosis, and treatment responses, in particular those measurable in blood, are largely lacking. We have investigated a broad set of protein biomarkers in cerebrospinal …
View article: A novel neurodegenerative spectrum disorder in patients with MLKL deficiency
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency Open
View article: Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases
Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases Open
View article: Identifying cross-disease components of genetic risk across hospital data in the UK Biobank
Identifying cross-disease components of genetic risk across hospital data in the UK Biobank Open
View article: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2 Open
Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac patient–derived…
View article: A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity Open
View article: The Human Cell Atlas White Paper
The Human Cell Atlas White Paper Open
The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all human cells - the fundamental units of life - as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating di…
View article: The Human Cell Atlas White Paper
The Human Cell Atlas White Paper Open
The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all human cells - the fundamental units of life - as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating di…
View article: Systematic classification of shared components of genetic risk for common human diseases
Systematic classification of shared components of genetic risk for common human diseases Open
Disease classification is fundamental to clinical practice, but current taxonomies do not necessarily reflect the pathophysiological processes that are common or unique to different disorders, such as those determined by genetic risk facto…
View article: The Human Cell Atlas
The Human Cell Atlas Open
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human bo…
View article: Author response: The Human Cell Atlas
Author response: The Human Cell Atlas Open
Article Figures and data Abstract Introduction What is the Human Cell Atlas, and what could we learn from it? Taxonomy: cell types Histology: cell neighborhood and position Development: transitions to differentiated cell types Physiology a…
View article: Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank Open