Lars Gille
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View article: Activity of Cochleates-Like Formulations of Artemisinin Against Leishmania Amazonensis
Activity of Cochleates-Like Formulations of Artemisinin Against Leishmania Amazonensis Open
View article: Negative effect and removal of trace amounts of 1,3-dialkylimidazolium ionic liquids in samples from biorefineries
Negative effect and removal of trace amounts of 1,3-dialkylimidazolium ionic liquids in samples from biorefineries Open
Ionic liquids (ILs), based on 1,3-dialkylimidazolium cations, are frequently used solvent components or auxiliaries for various types of biomass in biorefinery approaches. Unless washing and sample preparation have been carried out very ca…
View article: Eugenol-Rich Essential Oil from Pimenta dioica: In Vitro and In Vivo Potentialities against Leishmania amazonensis
Eugenol-Rich Essential Oil from Pimenta dioica: In Vitro and In Vivo Potentialities against Leishmania amazonensis Open
Pimenta dioica L. is one the most recognized species with diverse biological activities. In this study, in vitro activity and in vivo efficacy of essential oil from P. dioica (EO-Pd) was evaluated. The main compound was also included in th…
View article: Redox Cycling of Tetrahedral Iron Drives the Fenton Reactivity of Chrysotile Asbestos
Redox Cycling of Tetrahedral Iron Drives the Fenton Reactivity of Chrysotile Asbestos Open
Chrysotile asbestos is a carcinogenic fibrous mineral. Its pathogenicity is partly governed by the ability of Fe on the fiber surface to catalyze the Fenton reduction of H2O2 (which is produced during inflammatory processes) to form the hi…
View article: Radical Scavenging Is Not Involved in Thymoquinone-Induced Cell Protection in Neural Oxidative Stress Models
Radical Scavenging Is Not Involved in Thymoquinone-Induced Cell Protection in Neural Oxidative Stress Models Open
Thymoquinone (TQ), an active compound from Nigella sativa seeds, is often described as a pharmacologically relevant compound with antioxidative properties, while the synthesis of TQ in the plant via oxidations makes it inapplicable for sca…
View article: The Potential Contribution of Hexavalent Chromium to the Carcinogenicity of Chrysotile Asbestos
The Potential Contribution of Hexavalent Chromium to the Carcinogenicity of Chrysotile Asbestos Open
Chrysotile asbestos is a carcinogenic mineral that has abundantly been used in industrial and consumer applications. The carcinogenicity of the fibers is partly governed by reactive Fe surface sites that catalyze the generation of highly t…
View article: Antileishmanial Anthracene Endoperoxides: Efficacy In Vitro, Mechanisms and Structure-Activity Relationships
Antileishmanial Anthracene Endoperoxides: Efficacy In Vitro, Mechanisms and Structure-Activity Relationships Open
Leishmaniasis is a vector-borne disease caused by protozoal Leishmania parasites. Previous studies have shown that endoperoxides (EP) can selectively kill Leishmania in host cells. Therefore, we studied in this work a set of new anthracene…
View article: Soil-pH and cement influence the weathering kinetics of chrysotile asbestos in soils and its hydroxyl radical yield
Soil-pH and cement influence the weathering kinetics of chrysotile asbestos in soils and its hydroxyl radical yield Open
Chrysotile asbestos is a toxic and carcinogenic mineral that has been used in a variety of industrial and consumer applications. Much of the fiber- and cement-containing asbestos waste has ended up in terrestrial environments. Chrysotile w…
View article: Essential Oil from Melaleuca leucadendra: Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment
Essential Oil from Melaleuca leucadendra: Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment Open
Essential oils (EOs) are known for their use in cosmetics, food industries, and traditional medicine. This study presents the chemical composition and therapeutic properties against kinetoplastid and eukaryotic cells of the EO from Melaleu…
View article: Pharmacological Assessment of the Carvacrol Chemotype Essential Oil From <i>Plectranthus amboinicus</i> Growing in Cuba
Pharmacological Assessment of the Carvacrol Chemotype Essential Oil From <i>Plectranthus amboinicus</i> Growing in Cuba Open
Plant-derived products are employed in various public health practices and have been considered as a major source of medicines. The genus Plectranthus (Lamiaceae) has been widely respected for its nutritional properties, its essential oil,…
View article: Antileishmanial Activity and Influence on Mitochondria of the Essential Oil from Tagetes lucida Cav. and Its Main Component
Antileishmanial Activity and Influence on Mitochondria of the Essential Oil from Tagetes lucida Cav. and Its Main Component Open
Current antileishmanial drugs are toxic, expensive, and resistance to them has emerged. Several studies have focused on natural products as alternatives. In the present work, the chemical composition, in vitro antileishmanial activity, cyt…
View article: Identifying the reactive sites of hydrogen peroxide decomposition and hydroxyl radical formation on chrysotile asbestos surfaces
Identifying the reactive sites of hydrogen peroxide decomposition and hydroxyl radical formation on chrysotile asbestos surfaces Open
View article: Activation of artemisinin and heme degradation in Leishmania tarentolae promastigotes: A possible link
Activation of artemisinin and heme degradation in Leishmania tarentolae promastigotes: A possible link Open
View article: Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins
Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins Open
View article: Membrane Lipids Alter Uncoupling Effect of 2,4 Dinitrophenol
Membrane Lipids Alter Uncoupling Effect of 2,4 Dinitrophenol Open
View article: Techniques to study phagocytosis and uptake of Leishmania tarentolae by J774 macrophages
Techniques to study phagocytosis and uptake of Leishmania tarentolae by J774 macrophages Open
View article: The Effect of pH and Biogenic Ligands on the Weathering of Chrysotile Asbestos: The Pivotal Role of Tetrahedral Fe in Dissolution Kinetics and Radical Formation
The Effect of pH and Biogenic Ligands on the Weathering of Chrysotile Asbestos: The Pivotal Role of Tetrahedral Fe in Dissolution Kinetics and Radical Formation Open
Chrysotile asbestos is a soil pollutant in many countries. It is a carcinogenic mineral, partly due to its surface chemistry. In chrysotile, Fe II and Fe III substitute Mg octahedra (Fe[6]), and Fe III substitutes Si tetrahedra (Fe[4]). Fe…
View article: Activation of Anthracene Endoperoxides in Leishmania and Impairment of Mitochondrial Functions
Activation of Anthracene Endoperoxides in Leishmania and Impairment of Mitochondrial Functions Open
Leishmaniasis is a vector-borne disease caused by protozoal Leishmania. Because of resistance development against current drugs, new antileishmanial compounds are urgently needed. Endoperoxides (EPs) are successfully used in malaria therap…
View article: Cyclic peroxides as key intermediates in the degradation of cellulosic key chromophores by alkaline hydrogen peroxide: first direct proof by 17O NMR
Cyclic peroxides as key intermediates in the degradation of cellulosic key chromophores by alkaline hydrogen peroxide: first direct proof by 17O NMR Open
2,5-Dihydroxy-[1,4]-benzoquinone (DHBQ) and 5,8-dihydroxy-[1,4]-naphthoquinone (DHNQ) are two key chromophores which are almost ubiquitous in cellulosic materials. Their fate under conditions of alkaline peroxide bleaching (P stage) has be…
View article: Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of<i>Chenopodium ambrosioides</i>L. with mitochondria in<i>Leishmania</i>and other eukaryotes
Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of<i>Chenopodium ambrosioides</i>L. with mitochondria in<i>Leishmania</i>and other eukaryotes Open
The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major…
View article: Genipin Lacks the Specificity for UCP2 Inhibition
Genipin Lacks the Specificity for UCP2 Inhibition Open
View article: Expansion of <i><scp>BCR</scp>/<scp>ABL</scp>1</i><sup>+</sup> cells requires <scp>PAK</scp>2 but not <scp>PAK</scp>1
Expansion of <i><span>BCR</span>/<span>ABL</span>1</i><sup>+</sup> cells requires <span>PAK</span>2 but not <span>PAK</span>1 Open
Summary The p21‐activated kinases ( PAK s) are key nodes in oncogenic signalling pathways controlling growth, survival, and motility of cancer cells. Their activity is increased in many human cancers and is associated with poor prognosis. …
View article: The antileishmanial activity of xanthohumol is mediated by mitochondrial inhibition
The antileishmanial activity of xanthohumol is mediated by mitochondrial inhibition Open
SUMMARY Xanthohumol (Xan) is a natural constituent of human nutrition. Little is known about its actions on leishmanial parasites and their mitochondria as putative target. Therefore, we determined the antileishmanial activity of Xan and r…
View article: Attempting to Understand Health Effects Associated with Tea Consumption by Investigating Complexation Reactions with Copper
Attempting to Understand Health Effects Associated with Tea Consumption by Investigating Complexation Reactions with Copper Open
Tea consumption is associated with many health benefits including protection against neurodegenerative disorders, heart disease and viral infections, and stimulation of brain activity, it has also been reported to help diabetes prevention,…
View article: Lactation Affects Isolated Mitochondria and Its Fatty Acid Composition but Has No Effect on Tissue Protein Oxidation, Lipid Peroxidation or DNA-Damage in Laboratory Mice
Lactation Affects Isolated Mitochondria and Its Fatty Acid Composition but Has No Effect on Tissue Protein Oxidation, Lipid Peroxidation or DNA-Damage in Laboratory Mice Open
Linking peak energy metabolism to lifespan and aging remains a major question especially when focusing on lactation in females. We studied, if and how lactation affects in vitro mitochondrial oxygen consumption and mitochondrial fatty acid…
View article: CCDC 810211: Experimental Crystal Structure Determination
CCDC 810211: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Dependence of UCP-mediated proton conductance on HNE concentration.
Dependence of UCP-mediated proton conductance on HNE concentration. Open
Membranes from E. polar lipid were reconstituted with 15% arachidonic acid and 10.5 µg/(mg lipid) UCP1 (charge 19). Buffer solution contained 50 mM Na2SO4, 10 mM Tris, 10 mM MES, 0,6 mM EGTA, at pH 7.5 and T = 32°C. D…
View article: The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions
The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions Open
View article: Modified Aminophospholipids Strongly Alter the Function of Mitochondrial Membrane Protein UCP1
Modified Aminophospholipids Strongly Alter the Function of Mitochondrial Membrane Protein UCP1 Open