Lars Goebel
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View article: Inherent Bias in ROSA® Zimmer Biomet Pre-Op Planning Using 2D to 3D X-Atlas® Coronal Knee Axis Measurement
Inherent Bias in ROSA® Zimmer Biomet Pre-Op Planning Using 2D to 3D X-Atlas® Coronal Knee Axis Measurement Open
Background: Robotic assistance is considered capable of improving precision and outcomes of total knee replacement. We assessed the inherent biases, pre-procedural planning accuracy using 2D to 3D X-Atlas®, and final knee axis outcomes of …
View article: Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep
Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep Open
The data provide high-resolution evidence that tibiofemoral alignment modulates early OA induced by a medial meniscus injury in adult sheep. Since underload inhibits early OA, these data also support the clinical value of strategies to red…
View article: Accuracy of Personalized Computed Tomographic 3D Templating for Acetabular Cup Placement in Revision Arthroplasty
Accuracy of Personalized Computed Tomographic 3D Templating for Acetabular Cup Placement in Revision Arthroplasty Open
Background: Revision hip arthroplasty presents a surgical challenge, necessitating meticulous preoperative planning to avert complications like periprosthetic fractures and aseptic loosening. Historically, assessment of the accuracy of thr…
View article: A Photopolymerizable Biocompatible Hyaluronic Acid Hydrogel Promotes Early Articular Cartilage Repair in a Minipig Model In Vivo
A Photopolymerizable Biocompatible Hyaluronic Acid Hydrogel Promotes Early Articular Cartilage Repair in a Minipig Model In Vivo Open
Articular cartilage defects represent an unsolved clinical challenge. Photopolymerizable hydrogels are attractive candidates supporting repair. This study investigates the short‐term safety and efficacy of two novel hyaluronic acid (HA)‐tr…
View article: Subgroup analysis of scientific performance in the field of arthroplasty
Subgroup analysis of scientific performance in the field of arthroplasty Open
Introduction Arthroplasty is the final treatment option for maintaining mobility and quality of life in many primary degenerative and (post-) traumatic joint diseases. Identification of research output and potential deficits for specific s…
View article: In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year
In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year Open
View article: Hydrogel‐Guided, rAAV‐Mediated IGF‐I Overexpression Enables Long‐Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large‐Animal Full‐Thickness Chondral Defect Model at One Year In Vivo
Hydrogel‐Guided, rAAV‐Mediated IGF‐I Overexpression Enables Long‐Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large‐Animal Full‐Thickness Chondral Defect Model at One Year In Vivo Open
The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial‐guided gene therapy may enhance cartilage repair b…
View article: Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno‐Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno‐Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects Open
Advanced biomaterial‐guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery of gene vectors in a spatiote…
View article: Topographic modeling of early human osteoarthritis in sheep
Topographic modeling of early human osteoarthritis in sheep Open
Early osteoarthritis induced in a clinically relevant ovine model progresses in a highly specific spatiotemporal pattern resembling human OA.
View article: Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces
Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces Open
Selecting identical topographical locations to analyse pathological structural changes of the osteochondral unit in translational models remains difficult. The specific aim of the study was to provide objectively defined reference points o…
View article: Subchondral drilling for articular cartilage repair: a systematic review of translational research
Subchondral drilling for articular cartilage repair: a systematic review of translational research Open
Articular cartilage defects may initiate osteoarthritis. Subchondral drilling, a widely applied clinical technique to treat small cartilage defects, does not yield cartilage regeneration. Various translational studies aiming to improve the…
View article: Erratum zu: Die Meniskusläsion – ein präarthrotischer Zustand des Kniegelenks
Erratum zu: Die Meniskusläsion – ein präarthrotischer Zustand des Kniegelenks Open
View article: Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair
Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair Open
Microfracture of cartilage defects may induce alterations of the subchondral bone in the mid- and long-term, yet very little is known about their onset. Possibly, these changes may be avoided by an enhanced microfracture technique with add…
View article: Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep
Macroscopic cartilage repair scoring of defect fill, integration and total points correlate with corresponding items in histological scoring systems – a study in adult sheep Open
View article: A novel algorithm for a precise analysis of subchondral bone alterations
A novel algorithm for a precise analysis of subchondral bone alterations Open
View article: High resolution MRI imaging at 9.4 Tesla of the osteochondral unit in a translational model of articular cartilage repair
High resolution MRI imaging at 9.4 Tesla of the osteochondral unit in a translational model of articular cartilage repair Open
High resolution, non-destructive ex vivo analysis of the entire osteochondral unit in a preclinical large animal model that is sufficient for further analyses is possible using μMRI at 9.4 T. In particular, 9.4 T is capable of accurately d…
View article: Axial knee alignment influences the repair of focal articular cartilage defects – A translational study in sheep
Axial knee alignment influences the repair of focal articular cartilage defects – A translational study in sheep Open