Sander Jansen
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View article: Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes
Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes Open
Viruses exploit extracellular vesicles (EVs) to transfer infection-enhancing viral RNAs. However, mechanisms underlying viral RNA loading remain elusive. We leveraged our previous discovery that dengue virus secretes transmission-enhancing…
View article: Real-Time Diverse Fiber Sensing Multi-Event Detection using Phase OTDR Measurements
Real-Time Diverse Fiber Sensing Multi-Event Detection using Phase OTDR Measurements Open
We demonstrate an experimental phase optical time-domain reflectometry (OTDR) system capable of simultaneous detection and classification of various environ-mental events, such as wind-induced fiber movement, vehicle movement, and audio si…
View article: Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells
Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells Open
SUMMARY Tracking of viral replication and tissue tropism by in vivo imaging can help to unveil how live-attenuated vaccines such as the yellow fever 17D (17D) work, and likewise, to understand how adverse effects develop. Here we validate …
View article: Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study
Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study Open
Research Foundation Flanders, KU Leuven, UZ Leuven, VIB, the Fundação para a Ciência e a Tecnologia, the European Regional Development Fund, la Caixa Foundation, the Flemish Government, and Horizon 2020.
View article: Branch Identification in Passive Optical Networks using Machine Learning
Branch Identification in Passive Optical Networks using Machine Learning Open
A machine learning approach for improving monitoring in passive optical networks with almost equidistant branches is proposed and experimentally validated. It achieves a high diagnostic accuracy of 98.7% and an event localization error of …
View article: The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution
The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution Open
Aims Severe acute respiratory syndrome coronavirus-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distress syndrome (ARDS). Transcriptome signatures and the functional relevance of non-vascular…
View article: Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 Open
Research Foundation-Flanders (G0G4720N, 1843418N), KU Leuven COVID research fund.
View article: Biodistribution and Environmental Safety of a Live-attenuated YF17D-vectored SARS-CoV-2 Vaccine Candidate
Biodistribution and Environmental Safety of a Live-attenuated YF17D-vectored SARS-CoV-2 Vaccine Candidate Open
New platforms are urgently needed for the design of novel prophylactic vaccines and advanced immune therapies. Live-attenuated yellow fever vaccine YF17D serves as vector for several licensed vaccines and platform for novel vaccine candida…
View article: QoT assessment of the optical spectrum as a service in disaggregated network scenarios
QoT assessment of the optical spectrum as a service in disaggregated network scenarios Open
The potential to operate third-party terminals over multi-domain transparent optical networks attracts operators and customers to implement optical spectrum as a service (OSaaS). Because infrastructure information cannot always be shared w…
View article: Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome Open
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the i…
View article: Identification of host-factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
Identification of host-factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome Open
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the i…
View article: Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome
Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome Open
Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the i…
View article: Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host Open
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine…
View article: Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity Open
Epidemiological and clinical reports have indicated that the host immune response to SARS-CoV-2, more so than viral factors, determines COVID-19 disease severity. To elucidate the immunopathology underlying COVID-19 severity, cytokine and …
View article: Identification of TMEM106B as proviral host factor for SARS-CoV-2
Identification of TMEM106B as proviral host factor for SARS-CoV-2 Open
SUMMARY The ongoing COVID-19 pandemic is responsible for worldwide economic damage and nearly one million deaths. Potent drugs for the treatment of severe SARS-CoV-2 infections are not yet available. To identify host factors that support c…
View article: Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages
Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages Open
How innate and adaptive lung immune responses to SARS-CoV-2 synchronize during COVID-19 pneumonitis and regulate disease severity is poorly established. To address this, we applied single-cell profiling to bronchoalveolar lavages from 44 p…
View article: A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate
A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate Open
The explosively expanding COVID-19 pandemic urges the development of safe, efficacious and fast-acting vaccines to quench the unrestrained spread of SARS-CoV-2. Several promising vaccine platforms, developed in recent years, are leveraged …
View article: The Development of RNA-KISS, a Mammalian Three-Hybrid Method to Detect RNA–Protein Interactions in Living Mammalian Cells
The Development of RNA-KISS, a Mammalian Three-Hybrid Method to Detect RNA–Protein Interactions in Living Mammalian Cells Open
RNA-protein interactions are essential for the regulation of mRNA and noncoding RNA functions and are implicated in many diseases, such as cancer and neurodegenerative disorders. A method that can detect RNA-protein interactions in living …
View article: Conclusions
Conclusions Open
For many EU and non-EU countries, speeding up administrative decision-making has been a prominent topic over the last decade. In Germany, mainly due to the needs of the reunification, this was already topical at the beginning of the 1990s.…
View article: Introduction
Introduction Open
The economic crisis that afflicted Europe in 2008 has been considered a major hindrance to investments and development in many EU countries. While in 2016 the situation is not as dire as a few years back, the effects are still very much pr…