Lars Kaestner
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View article: Special Issue “Ion Conductance and Ion Regulation in Human Health and Disease”
Special Issue “Ion Conductance and Ion Regulation in Human Health and Disease” Open
Ion concentration gradients across the cell membrane are fundamental to numerous processes that define life [...]
View article: A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture
A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture Open
When Neanderthals and anatomically modern humans interbred, they may have faced conditional reproductive barriers. We identify a likely maternal-fetal incompatibility involving a Neanderthal PIEZO1 gene variant predicted to increase red bl…
View article: Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance
Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance Open
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mecha…
View article: Piezo1 Channel Activators Yoda1 and Yoda2 in the Context of Red Blood Cells
Piezo1 Channel Activators Yoda1 and Yoda2 in the Context of Red Blood Cells Open
Piezo1 is a mechanosensitive non-selective cation channel. Genetic alterations of the channel result in a hematologic phenotype named Hereditary Xerocytosis. With Yoda1 and, more recently, Yoda2, compounds to increase the activity of Piezo…
View article: Editorial: Progress in neuroacanthocytosis syndromes and related diseases including other bulk lipid transfer disorders
Editorial: Progress in neuroacanthocytosis syndromes and related diseases including other bulk lipid transfer disorders Open
View article: Piezo 1 Channel Activators Yoda1 and Yoda2 in the Context of Red Blood Cells
Piezo 1 Channel Activators Yoda1 and Yoda2 in the Context of Red Blood Cells Open
Piezo1 is a mechanosensitive non-selective cation channel. Genetic alterations of the channel result in a hematologic phenotype named Hereditary Xerocytosis. With Yoda1 and more recently Yoda2, compounds to increase the activity of Piezo1 …
View article: Red blood cell lipid distribution in the pathophysiology and laboratory evaluation of chorea-acanthocytosis and McLeod syndrome patients
Red blood cell lipid distribution in the pathophysiology and laboratory evaluation of chorea-acanthocytosis and McLeod syndrome patients Open
The core neuroacanthocytosis syndromes, i.e. , chorea-acanthocytosis/VPS13A disease (ChAc) and McLeod syndrome/XK disease (MLS), are respectively due to mutations in VPS13A and XK genes and share similar manifestations including the format…
View article: Historical View and Some Unsolved Problems in Red Blood Cell Membrane Research
Historical View and Some Unsolved Problems in Red Blood Cell Membrane Research Open
The article provides a comprehensive overview of biological membrane lipid composition and distribution and ion transport processes, focusing particularly on red blood cells (RBCs). It begins with a historical perspective, detailing the in…
View article: Insights from lipidomics into the terminal maturation of circulating human reticulocytes
Insights from lipidomics into the terminal maturation of circulating human reticulocytes Open
In the age of “omics”, lipidomics of erythropoiesis is still missing. How reticulocytes mature in the circulation into functional erythrocytes is also largely unknown. We have isolated here two populations of human circulating reticulocyte…
View article: AlkaPhos: a novel fluorescent probe as a potential point-of-care diagnostic tool to estimate recurrence risk of meningiomas
AlkaPhos: a novel fluorescent probe as a potential point-of-care diagnostic tool to estimate recurrence risk of meningiomas Open
View article: Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand
Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand Open
View article: Oxidantscan: a novel biomarker to assess red blood cell susceptibility to oxidative stress in sickle cell disease
Oxidantscan: a novel biomarker to assess red blood cell susceptibility to oxidative stress in sickle cell disease Open
View article: Progress in Neuroacanthocytosis Syndromes and Related Diseases Including other Bulk Lipid Transfer Disorders
Progress in Neuroacanthocytosis Syndromes and Related Diseases Including other Bulk Lipid Transfer Disorders Open
View article: Sodium-Selective Channelrhodopsins
Sodium-Selective Channelrhodopsins Open
Channelrhodopsins (ChRs) are light-gated ion channels originally discovered in algae and are commonly used in neuroscience for controlling the electrical activity of neurons with high precision. Initially-discovered ChRs were non-selective…
View article: Deposit of Red Blood Cells at low concentrations in evaporating droplets is dominated by a central edge growth
Deposit of Red Blood Cells at low concentrations in evaporating droplets is dominated by a central edge growth Open
View article: Reply to McGowan et al.: An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red blood cells is linked to expression of RhCE blood groups
Reply to McGowan et al.: An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red blood cells is linked to expression of RhCE blood groups Open
Large volumes of liquid water transiently existed on the surface of Mars more than 3 billion years ago. Much of this water is hypothesized to have been sequestered in the subsurface or lost to space. We use rock physics models and Bayesian…
View article: Osmotic gradient ektacytometry – a novel diagnostic approach for neuroacanthocytosis syndromes
Osmotic gradient ektacytometry – a novel diagnostic approach for neuroacanthocytosis syndromes Open
Introduction The unique red blood cell (RBC) properties that characterize the rare neuroacanthocytosis syndromes (NAS) have prompted the exploration of osmotic gradient ektacytometry (Osmoscan) as a diagnostic tool for these disorders. In …
View article: Competing aggregation and iso-density equilibrium lead to band pattern formation in density gradients
Competing aggregation and iso-density equilibrium lead to band pattern formation in density gradients Open
Centrifugation of biological matter in density gradient solutions is a standard method for separating cell types or components. It is also used to separate red blood cells (RBCs) by age, as they lose water and become denser over their life…
View article: Deposit of Red Blood Cells at low concentrations in evaporating droplets: central edge growth and potential applications
Deposit of Red Blood Cells at low concentrations in evaporating droplets: central edge growth and potential applications Open
Evaporation of blood droplets and diluted blood samples is a topic of intensive research, as it is seen as a possible low-cost tool for diagnosis. So far, samples with volume fraction down to a few percents of Red Blood Cells (RBCs) have b…
View article: Editorial: Insights in red blood cell physiology: 2023
Editorial: Insights in red blood cell physiology: 2023 Open
Keywords: sickle cell disease, drug transport, asplenia, transfusion, extracellular vesicle release, GP.Mur, COVID-19, hemorheology
View article: Making a virtue out of an evil: Are red blood cells from chronic mountain sickness patients eligible for transfusions?
Making a virtue out of an evil: Are red blood cells from chronic mountain sickness patients eligible for transfusions? Open
We investigated highlanders, permanently living at an altitude of 5100 m and compared Chronic Mountain Sickness (CMS) patients with control volunteers. While we found differences in systemic parameters such as blood oxygen content, hematoc…
View article: Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability?
Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability? Open
Chronic mountain sickness is a maladaptive syndrome that affects individuals living permanently at high altitude and is characterized primarily by excessive erythrocytosis (EE). Recent results concerning the impact of EE in Andean highland…
View article: Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion
Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion Open
International audience
View article: Advances in Red Blood Cells Research
Advances in Red Blood Cells Research Open
This Editorial ‘Advances in Red Blood Cell Research’ is the preface for the special issue with the same title which files 14 contributions listed in Table 1 [...]
View article: The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells
The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells Open
The Gárdos channel (KCNN4) and Piezo1 are the best-known ion channels in the red blood cell (RBC) membrane. Nevertheless, the quantitative electrophysiological behavior of RBCs and its heterogeneity are still not completely understood. Her…
View article: Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude
Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude Open
Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes to physiological human adaptations to hypoxia, a multifaceted process critical to health and disease. To delve into the molecular underpinnings of this…
View article: Early stage of erythrocyte sedimentation rate test: Fracture of a high-volume-fraction gel
Early stage of erythrocyte sedimentation rate test: Fracture of a high-volume-fraction gel Open
Erythrocyte sedimentation rate (ESR) is a clinical parameter used as a nonspecific marker for inflammation, and recent studies have shown that it is linked to the collapse of the gel formed by red blood cells (RBCs) at physiological hemato…
View article: The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells
The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells Open
(1) Background: The Gárdos channel (KCNN4) and Piezo1 are the best-known ion channels in the red blood cell (RBC) membrane. Nevertheless, the quantitative electrophysiological behavior of RBCs and its heterogeneity are still not completely…
View article: A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation Open
PIEZO1 channels are mechanically activated cation channels that play a pivotal role in sensing mechanical forces in various cell types. Their dysfunction has been associated with numerous pathophysiological states, including generalized ly…
View article: A novel missense variant in <scp><i>ATP11C</i></scp> is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia
A novel missense variant in <span><i>ATP11C</i></span> is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia Open
Adenosine Triphosphatase (ATPase) Phospholipid Transporting 11C gene (ATP11C) encodes the major phosphatidylserine (PS) flippase in human red blood cells (RBCs). Flippases actively transport phospholipids (e.g., PS) from the outer to the i…