Lars Kjelsberg Pedersen
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View article: Patient selection and outcome in low-grade glioma surgery
Patient selection and outcome in low-grade glioma surgery Open
Background and objectives Maximal safe resection is the cornerstone of diffuse low-grade glioma (dLGG) management, although epidemiological data are limited. We aim to explore surgical selection, techniques, and outcomes in a population-ba…
View article: Potential impact of [18F]-FACBC PET in radiotherapy target definition of glioma
Potential impact of [18F]-FACBC PET in radiotherapy target definition of glioma Open
Purpose The aim of the study was to compare [18F]-FACBC positron emission tomography (PET)-based radiotherapy (RT) volumes to magnetic resonance (MR)-based volumes and investigate the potential impact of including [18F]-FACBC PET in RT tre…
View article: Combined High-Resolution MRSI and [18F]-FACBC PET to Improve the Presurgical Diagnostic Accuracy in Gliomas
Combined High-Resolution MRSI and [18F]-FACBC PET to Improve the Presurgical Diagnostic Accuracy in Gliomas Open
Medical imaging is crucial for glioma management. Combined with MRI, amino acid PET may improve glioma diagnosis, biopsy targeting, and tumor delineation compared to structural MRI alone. Magnetic resonance spectroscopic imaging (MRSI) com…
View article: Unraveling differences and hallmarks in suspected diffuse low-grade gliomas: a multicenter database study
Unraveling differences and hallmarks in suspected diffuse low-grade gliomas: a multicenter database study Open
The natural history of suspected diffuse low-grade gliomas (DLGG) depends heavily upon the molecular status. To fully comprehend this integrated information preoperatively, a clinical phenotype incorporating both clinical and radiological …
View article: Is tumor shape associated with molecular diagnosis, extent of resection, or postoperative focal deficits in diffuse low-grade gliomas?
Is tumor shape associated with molecular diagnosis, extent of resection, or postoperative focal deficits in diffuse low-grade gliomas? Open
Background This study aimed to explore the potential association between tumor shape, 1p/19q codeletion, EOR, and new postoperative focal deficits in patients with diffuse low-grade glioma. Methods We analyzed data from 225 WHO grade 2 gli…
View article: Histomolecular Validation of [18F]-FACBC in Gliomas Using Image-Localized Biopsies
Histomolecular Validation of [18F]-FACBC in Gliomas Using Image-Localized Biopsies Open
Background: Gliomas have a heterogeneous nature, and identifying the most aggressive parts of the tumor and defining tumor borders are important for histomolecular diagnosis, surgical resection, and radiation therapy planning. This study e…
View article: Long-term follow up of patients with WHO grade 2 oligodendroglioma
Long-term follow up of patients with WHO grade 2 oligodendroglioma Open
Purpose Since the introduction of the molecular definition of oligodendrogliomas based on isocitrate dehydrogenase ( IDH )-status and the 1p19q-codeletion, it has become increasingly evident how this glioma entity differs much from other d…
View article: Diagnostic Value of 18F-FACBC PET/MRI in Brain Metastases
Diagnostic Value of 18F-FACBC PET/MRI in Brain Metastases Open
Purpose The study aims to evaluate whether combined 18 F-FACBC PET/MRI could provide additional diagnostic information compared with MRI alone in brain metastases. Patients and Methods Eighteen patients with newly diagnosed or suspected re…
View article: Decompressive hemicraniectomy for space-occupying brain infarction: Nationwide population-based registry study
Decompressive hemicraniectomy for space-occupying brain infarction: Nationwide population-based registry study Open
The findings indicate gender- and geographic-inequalities in access. Among operated cases, outcomes were comparable with those reported from RCTs, and the use in accordance with recommendations in the current guidelines from the American S…
View article: Endoscopic third ventriculostomy for adults with hydrocephalus: creating a prognostic model for success: protocol for a retrospective multicentre study (Nordic ETV)
Endoscopic third ventriculostomy for adults with hydrocephalus: creating a prognostic model for success: protocol for a retrospective multicentre study (Nordic ETV) Open
Introduction Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread treatment for hydrocephalus, but research is primarily based on paediatric populations. In 2009, Kulkarni et al created the ETV Success score to pre…
View article: Obstetric care for women that use antidepressants in pregnancy
Obstetric care for women that use antidepressants in pregnancy Open
Obstetric care for women that use antidepressants in pregnancyLine Kolding, MD, PhDVera Ehrenstein, MPH, DSc, ProfessorLars Pedersen, MSc, PhD, ProfessorPuk Sandager, MD, PhD, Associate ProfessorOlav B. Petersen, MD, PhD, ProfessorNiels Ul…
View article: Variations in the management of diffuse low-grade gliomas—A Scandinavian multicenter study
Variations in the management of diffuse low-grade gliomas—A Scandinavian multicenter study Open
Background Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected “high-risk” patients. Still, there are…
View article: Triple Use of Autologous Amnion Graft in the Treatment of Meningomyelocele and Split Cord Malformation
Triple Use of Autologous Amnion Graft in the Treatment of Meningomyelocele and Split Cord Malformation Open
Summary: This article describes the triple use of autologous amnion graft as a new procedure in the treatment of myelomeningocele and in myelomeningocele with split cord malformation. The first amnion graft was used as a physical and mecha…
View article: Additional file 1 of Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study
Additional file 1 of Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study Open
Additional file 1 : Supporting Information.xlsx Description of data: Excel document containing 1). Table S1. of characteristics of databases utilised in this study 2). Table S2. of clinical diagnosis codes for disease variables 3). Table S…
View article: Methotrexate and relative risk of dementia amongst patients with Rheumatoid Arthritis: a multi-national multi-database case-control study
Methotrexate and relative risk of dementia amongst patients with Rheumatoid Arthritis: a multi-national multi-database case-control study Open
Inflammatory processes have been shown to play a role in dementia. To understand this role we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk.METHODS A retrospective match…