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View article: Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration
Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration Open
Chronic wounds and severe skin injuries pose significant clinical challenges, as existing treatments like cultured epidermal autografts and tissue engineering strategies fail to regenerate functional dermal tissue effectively. These method…
View article: Translation and evaluation of the Infant Characteristics Questionnaire in a sample of Swedish patients with craniosynostosis
Translation and evaluation of the Infant Characteristics Questionnaire in a sample of Swedish patients with craniosynostosis Open
Background: Research on the psychological development of infants with craniosynostosis would benefit from further properly validated tailored measures. Aim: Our study aimed to translate and evaluate the Infant Characteristics Questionnaire…
View article: Dynamic osteodistraction with springs – the Gothenburg experience of spring-assisted cranioplasty
Dynamic osteodistraction with springs – the Gothenburg experience of spring-assisted cranioplasty Open
Surgical treatment of craniosynostosis includes a wide range of techniques. Although a variety of more extensive cranioplasties have been employed to enhance outcomes, efforts to identify less invasive surgical approaches with better resul…
View article: Moving beyond surgical excellence: a qualitative systematic review into the perspectives and experiences of children, adolescents, and adults living with a rare congenital craniofacial condition and their parents
Moving beyond surgical excellence: a qualitative systematic review into the perspectives and experiences of children, adolescents, and adults living with a rare congenital craniofacial condition and their parents Open
This qualitative systematic review aims to get a better understanding of what it means to live with a rare congenital craniofacial condition according to patients and their parents. Eight patient representatives provided input to this stud…
View article: Prevalence and treatment outcomes of hydrocephalus among children with craniofacial syndromes
Prevalence and treatment outcomes of hydrocephalus among children with craniofacial syndromes Open
Introduction: Hydrocephalus is more common in patients with craniofacial syndromes (CS) relative to non-syndromic craniosynostosis, and the optimal management is challenging. This study examined the prevalence and treatment outcomes of hyd…
View article: Surgical Correction of Unicoronal Synostosis: Fronto-Orbital Distraction versus Calvarial Switch
Surgical Correction of Unicoronal Synostosis: Fronto-Orbital Distraction versus Calvarial Switch Open
Background: There is a need for a new, less-invasive surgical option for unicoronal synostosis (UCS). The aim of this study was to compare the resulting morphology and symmetry in patients with UCS after fronto-orbital distraction (FOD) or…
View article: Staged dissection reduces blood loss in surgery for metopic synostosis
Staged dissection reduces blood loss in surgery for metopic synostosis Open
INTRODUCTION: Fronto-orbital remodelling for metopic synostosis is an extensive operation with substantial blood loss, particularly from emissary veins in the glabellar region. One possibility to reduce blood loss may be to stage dissectio…
View article: Spring-assisted posterior vault expansion in children over 2 years of age with craniosynostosis
Spring-assisted posterior vault expansion in children over 2 years of age with craniosynostosis Open
Background: This study evaluated spring-assisted posterior vault expansion (SA-PVE) in children aged > 2 years with craniosynostosis and signs of high intracranial pressure (ICP). Methods: We retrospectively analysed all consecutive patien…
View article: <scp>BounTI</scp> (boundary‐preserving threshold iteration): A user‐friendly tool for automatic hard tissue segmentation
<span>BounTI</span> (boundary‐preserving threshold iteration): A user‐friendly tool for automatic hard tissue segmentation Open
X‐ray Computed Tomography (CT) images are widely used in various fields of natural, physical, and biological sciences. 3D reconstruction of the images involves segmentation of the structures of interest. Manual segmentation has been widely…
View article: Spring-Assisted Surgery of Unilambdoid Craniosynostosis
Spring-Assisted Surgery of Unilambdoid Craniosynostosis Open
Craniosynostosis is traditionally treated with extensive cranial vault reconstructions (CVRs). Although less invasive techniques, such as endoscopic strip craniectomy with postoperative helmet therapy, have been successful, they also prese…
View article: A European Multicenter Outcome Study of Perioperative Airway Management Policies following Midface Surgery in Syndromic Craniosynostosis
A European Multicenter Outcome Study of Perioperative Airway Management Policies following Midface Surgery in Syndromic Craniosynostosis Open
Background: Perioperative airway management following midface advancements in children with Apert and Crouzon–Pfeiffer syndromes can be challenging, and protocols often differ. This study examined airway management following midface advanc…
View article: The value of genome-wide analysis in craniosynostosis
The value of genome-wide analysis in craniosynostosis Open
Background: This study assessed the diagnostic yield of high-throughput sequencing methods in a cohort of craniosynostosis (CS) patients not presenting causal variants identified through previous targeted analysis. Methods: Whole-genome or…
View article: Correction of Unicoronal Synostosis With Springs: Two Patients With Improved Facial Symmetry
Correction of Unicoronal Synostosis With Springs: Two Patients With Improved Facial Symmetry Open
Objective: Surgical correction of unicoronal synostosis (UCS) entails extensive cranioplasties which do not address facial scoliosis. This paper presents the first results with springs that motivated the shift from extensive cranioplasties…
View article: Injectable In Situ Crosslinking Hydrogel for Autologous Fat Grafting
Injectable In Situ Crosslinking Hydrogel for Autologous Fat Grafting Open
Autologous fat grafting is hampered by unpredictable outcomes due to high tissue resorption. Hydrogels based on enzymatically pretreated tunicate nanocellulose (ETC) and alginate (ALG) are biocompatible, safe, and present physiochemical pr…
View article: Autologous endothelialisation by the stromal vascular fraction on laminin-bioconjugated nanocellulose–alginate scaffolds
Autologous endothelialisation by the stromal vascular fraction on laminin-bioconjugated nanocellulose–alginate scaffolds Open
Establishing a vascular network in biofabricated tissue grafts is essential for ensuring graft survival. Such networks are dependent on the ability of the scaffold material to facilitate endothelial cell adhesion; however, the clinical tra…
View article: Improved Facial and Skull-Base Symmetry following Osteotomy and Distraction of Unilateral Coronal Synostosis
Improved Facial and Skull-Base Symmetry following Osteotomy and Distraction of Unilateral Coronal Synostosis Open
Background: Unilateral coronal synostosis (UCS) results in a surgically demanding deformation, as the deformity is asymmetric in the calvaria but also presents with facial scoliosis and orbital dystopia. Traditional cranioplasties correct …
View article: Circulating Brain-Injury Markers After Surgery for Craniosynostosis
Circulating Brain-Injury Markers After Surgery for Craniosynostosis Open
These represent the first results showing significantly increased plasma levels of brain-injury biomarkers after surgery for craniosynostosis. Furthermore, we found that more extensive cranial vault procedures resulted in higher levels of …
View article: Health-related quality of life of children treated for non-syndromic craniosynostosis
Health-related quality of life of children treated for non-syndromic craniosynostosis Open
Health-related quality of life (HRQoL) allows the acquisition of the subjective perspective of patients regarding their health and function; yet a very few studies have been evaluated HRQoL of patients treated for craniosynostosis (CS). In…
View article: A Computational Framework to Predict Calvarial Growth: Optimising Management of Sagittal Craniosynostosis
A Computational Framework to Predict Calvarial Growth: Optimising Management of Sagittal Craniosynostosis Open
The neonate skull consists of several bony plates, connected by fibrous soft tissue called sutures. Premature fusion of sutures is a medical condition known as craniosynostosis. Sagittal synostosis, caused by premature fusion of the sagitt…
View article: Biomaterial and biocompatibility evaluation of tunicate nanocellulose for tissue engineering
Biomaterial and biocompatibility evaluation of tunicate nanocellulose for tissue engineering Open
Extracellular matrix fibril components, such as collagen, are crucial for the structural properties of several tissues and organs. Tunicate-derived cellulose nanofibrils (TNC) combined with living cells could become the next gold standard …
View article: The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis
The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis Open
Here, we have studied the prevalence and spectrum of genetic alterations in syndromic forms of sagittal and pansynostosis. Eighteen patients with sagittal synostosis (isolated or combined with other synostoses, except coronal) or pansynost…
View article: Long-term <i>in vivo</i> survival of 3D-bioprinted human lipoaspirate-derived adipose tissue: proteomic signature and cellular content
Long-term <i>in vivo</i> survival of 3D-bioprinted human lipoaspirate-derived adipose tissue: proteomic signature and cellular content Open
Three-dimensional (3D)-bioprinted lipoaspirate-derived adipose tissue (LAT) is a potential alternative to lipo-injection for correcting soft-tissue defects. This study investigated the long-term in vivo survival of 3D-bioprinted LAT and it…
View article: Health-related Quality of Life of Children Treated for Non-syndromic Craniosynostosis
Health-related Quality of Life of Children Treated for Non-syndromic Craniosynostosis Open
Background: Assessing health-related quality of life (HRQoL) allows acquisition of the subjective perspective of patients regarding their health and functioning; however, little is known about the experiences of patients living with treate…
View article: Vascularization of tissue engineered cartilage - Sequential in vivo MRI display functional blood circulation
Vascularization of tissue engineered cartilage - Sequential in vivo MRI display functional blood circulation Open
Establishing functional circulation in bioengineered tissue after implantation is vital for the delivery of oxygen and nutrients to the cells. Native cartilage is avascular and thrives on diffusion, which in turn depends on proximity to ci…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
In this review, we summarize principles to navigate pa ents with GIST or so ssue sarcoma through the ongoing COVID-19 pandemic.We discuss risk stra fi ca on, the projected burden of resource u liza on, and the use of alternate nonsurgical …
View article: First‐year complications after immediate breast reconstruction with a biological and a synthetic mesh in the same patient: A randomized controlled study
First‐year complications after immediate breast reconstruction with a biological and a synthetic mesh in the same patient: A randomized controlled study Open
Background Even though meshes and matrices are widely used in breast reconstruction, there is little high‐quality scientific evidence for their risks and benefits. The aim of this study was to compare first‐year surgical complication rates…