Lars Mundhenk
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View article: The impact of disease and species differences on the intestinal CLCA4 gene expression
The impact of disease and species differences on the intestinal CLCA4 gene expression Open
The human chloride channel regulator, calcium-activated (CLCA) 4 is discussed as a driver of epithelial-to-mesenchymal transition as well as a biomarker for colorectal cancer (CRC) and ulcerative colitis. In contrast to humans, the Clca4 g…
View article: Repeated Injection of Very Small Superparamagnetic Iron Oxide Particles (VSOPs) in Murine Atherosclerosis: A Safety Study
Repeated Injection of Very Small Superparamagnetic Iron Oxide Particles (VSOPs) in Murine Atherosclerosis: A Safety Study Open
Citrate-coated electrostatically stabilized very small superparamagnetic iron oxide particles (VSOPs) have been successfully tested as magnetic resonance angiography (MRA) contrast agents and are promising tools for molecular imaging of at…
View article: Lethal Borna disease virus 1 (BoDV-1) infections of humans and animals – in-depth molecular epidemiology and phylogeography
Lethal Borna disease virus 1 (BoDV-1) infections of humans and animals – in-depth molecular epidemiology and phylogeography Open
Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a progressive and mostly fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored w…
View article: Genomic, biochemical and expressional properties reveal strong conservation of the <i>CLCA2</i> gene in birds and mammals
Genomic, biochemical and expressional properties reveal strong conservation of the <i>CLCA2</i> gene in birds and mammals Open
Recent studies have revealed the dynamic and complex evolution of CLCA1 gene homologues in and between mammals and birds with a particularly high diversity in mammals. In contrast, CLCA2 has only been found as a single copy gene in mammals…
View article: Rustrela virus infection – An emerging neuropathogen of red‐necked wallabies ( <i>Macropus rufogriseus</i> )
Rustrela virus infection – An emerging neuropathogen of red‐necked wallabies ( <i>Macropus rufogriseus</i> ) Open
The rustrela virus (RusV) was recently described as a novel pathogen in a circumscribed area of northern Germany close to the Baltic Sea. Up to now, the virus has been detected in cases of fatal non-suppurative meningoencephalitis in zoo a…
View article: Progressive Lameness of a Greater One-Horned Rhinoceros (Rhinoceros unicornis) Associated with a Retroperitoneal Abscess and Thrombus Caused by Streptococcus dysgalactiae Subspecies equisimilis
Progressive Lameness of a Greater One-Horned Rhinoceros (Rhinoceros unicornis) Associated with a Retroperitoneal Abscess and Thrombus Caused by Streptococcus dysgalactiae Subspecies equisimilis Open
In rhinoceroses, lameness is an occasionally seen symptom primarily caused by lesions affecting the feet and interdigital space. A 3-year-old male Greater one-horned rhinoceros developed a progressive, severe movement disorder of the right…
View article: Mystery of fatal ‘Staggering disease’ unravelled: Novel rustrela virus causes severe encephalomyelitis in domestic cats
Mystery of fatal ‘Staggering disease’ unravelled: Novel rustrela virus causes severe encephalomyelitis in domestic cats Open
‘Staggering disease’ is a neurological disorder considered a threat to European domestic cats ( Felis catus ) for almost five decades. However, its aetiology has remained obscure. Rustrela virus (RusV), a relative of rubella virus, has rec…
View article: Rustrela Virus Infection – A New Emerging Neuropathogen of Red-necked Wallabies ( Macropus rufogriseus)
Rustrela Virus Infection – A New Emerging Neuropathogen of Red-necked Wallabies ( Macropus rufogriseus) Open
The rustrela virus (RusV) was recently described as a novel pathogen in a circumscribed area of northern Germany close to the Baltic Sea. Up to now, the virus has been detected in cases of fatal non-suppurative meningoencephalitis in zoo a…
View article: Evolutionarily conserved properties of CLCA proteins 1, 3 and 4, as revealed by phylogenetic and biochemical studies in avian homologues
Evolutionarily conserved properties of CLCA proteins 1, 3 and 4, as revealed by phylogenetic and biochemical studies in avian homologues Open
Species-specific diversities are particular features of mammalian chloride channel regulator, calcium activated ( CLCA ) genes. In contrast to four complex gene clusters in mammals, only two CLCA genes appear to exist in chickens. CLCA2 is…
View article: DIVERSITÄT DER CLCA-GENFAMILIE ZWISCHEN AUSGEWÄHLTEN SÄUGERSPEZIES UND AUSWIRKUNGEN AUF DIE WAHL EINES TIERMODELLS
DIVERSITÄT DER CLCA-GENFAMILIE ZWISCHEN AUSGEWÄHLTEN SÄUGERSPEZIES UND AUSWIRKUNGEN AUF DIE WAHL EINES TIERMODELLS Open
View article: Periarticular histiocytic sarcoma in a domestic rabbit
Periarticular histiocytic sarcoma in a domestic rabbit Open
Articular tumours have only rarely been described in rabbits (Oryctolagus cuniculus). An 8-year-old, male castrated, domestic rabbit was presented with progressive right hindlimb lameness and its owners requested humane euthanasia. Radiogr…
View article: Grayanotoxin I Intoxication in Pet Pigs
Grayanotoxin I Intoxication in Pet Pigs Open
Contaminated honey is a common cause of grayanotoxin intoxication in humans. Intoxication of animals, especially cattle, is usually due to ingestion of plants of the Ericaceae family, such as Rhododendron. Here, we report the ingestion of …
View article: Proteinbiochemische Strukturanalysen der orthologen CLCA-Proteine eCLCA1 des\nPferdes und mCLCA3 der Maus
Proteinbiochemische Strukturanalysen der orthologen CLCA-Proteine eCLCA1 des\nPferdes und mCLCA3 der Maus Open
Deckblatt-Impressum \nWidmung \nPublikationshinweise \nInhalt \nVerzeichnis der Abkürzungsverzeichnis \nEinleitung \nLiteraturübersicht \nMaterial und Methoden \nErgebnisse \nDiskussion \nZusammenfassung \nSummary \nAbbildungsverzeichnis \…
View article: Oxidative Stress Imaging: Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging (Small 23/2018)
Oxidative Stress Imaging: Visualizing Oxidative Cellular Stress Induced by Nanoparticles in the Subcytotoxic Range Using Fluorescence Lifetime Imaging (Small 23/2018) Open
In article number 1800310, Nan Ma, Ulrike Alexiev, and co-workers develop a sensitive and reproducible fluorescence lifetime based imaging assay (FLIM-ROX) for reactive oxygen species (ROS) detection that allows the investigation of low ce…
View article: Fatal Neurotoxicosis in Dogs Associated with Tychoplanktic, Anatoxin-a Producing Tychonema sp. in Mesotrophic Lake Tegel, Berlin
Fatal Neurotoxicosis in Dogs Associated with Tychoplanktic, Anatoxin-a Producing Tychonema sp. in Mesotrophic Lake Tegel, Berlin Open
In May 2017, at least 12 dogs showed signs of acute neurotoxicosis after swimming in or drinking from Lake Tegel, a mesotrophic lake in Berlin, Germany, and several of the affected dogs died shortly afterwards despite intensive veterinary …
View article: Additional file 1: of Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin
Additional file 1: of Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin Open
Detailed Methods. (DOCX 40.1 kb)
View article: Additional file 2: of Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin
Additional file 2: of Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin Open
Schematic Experimental Protocol. (TIFF 916 kb)
View article: Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype
Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype Open
The human CLCA4 (chloride channel regulator, calcium-activated) modulates the intestinal phenotype of cystic fibrosis (CF) patients via an as yet unknown pathway. With the generation of new porcine CF models, species-specific differences b…
View article: The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice Open
The secreted, goblet cell-derived protein Clca1 (chloride channel regulator, calcium-activated-1) has been linked to diseases with mucus overproduction, including asthma and cystic fibrosis. In the intestine Clca1 is found in the mucus wit…
View article: Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques
Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques Open
The increasing interest and recent developments in nanotechnology pose previously unparalleled challenges in understanding the effects of nanoparticles on living tissues. Despite significant progress in in vitro cell and tissue culture tec…