Lars Arendt‐Nielsen
YOU?
Author Swipe
View article: Glial activation and increase in cerebral pro-inflammatory cytokine expression in a female animal post-COVID model
Glial activation and increase in cerebral pro-inflammatory cytokine expression in a female animal post-COVID model Open
View article: The impact of screening period pain inconsistency on placebo response in intra-articular knee osteoarthritis trials
The impact of screening period pain inconsistency on placebo response in intra-articular knee osteoarthritis trials Open
These findings extend earlier observations by revealing that not only the magnitude, but also the direction of screening pain fluctuation (worsening pain before randomization) predicts PR. These results highlight SPPI as a potential adjust…
View article: Experimental acute muscle pain and itch induce similar inhibitory effects on corticospinal excitability
Experimental acute muscle pain and itch induce similar inhibitory effects on corticospinal excitability Open
Introduction: Pain and itch provoke different motor behaviors. Pain induces motor inhibition, whereas itch triggers an active scratching response. Acute pain is known to decrease corticospinal excitability, assessed by transcranial magneti…
View article: Patient perceptions of recovery following surgical removal of an impacted mandibular third molar and application of advanced platelet-rich fibrin: a prospective randomized controlled clinical trial
Patient perceptions of recovery following surgical removal of an impacted mandibular third molar and application of advanced platelet-rich fibrin: a prospective randomized controlled clinical trial Open
The objective was to assess patient perceptions of recovery following surgical removal of mandibular third molar (SRM3) with application of advanced platelet-rich fibrin (A-PRF) (test) compared with SRM3 and no extraction socket interventi…
View article: Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3‐Week <scp>NSAID</scp> Plus Paracetamol in Patients With Painful Knee Osteoarthritis
Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3‐Week <span>NSAID</span> Plus Paracetamol in Patients With Painful Knee Osteoarthritis Open
Background Studies demonstrate that pain sensitization, epigenetic mechanisms, inflammation, and psychological factors might be predictive of treatment outcomes. Anti‐inflammatory therapy is recommended, but efficacy varies among patients.…
View article: Antibiotic-Only Treatment of Pediatric Retropharyngeal and Parapharyngeal Abscess: A Case Report
Antibiotic-Only Treatment of Pediatric Retropharyngeal and Parapharyngeal Abscess: A Case Report Open
Deep neck infections (DNIs) in children are rare and atypical in early clinical manifestations. They are frequently misdiagnosed or overlooked and have a rapid onset and can progress to life-threatening complications. There are only a few …
View article: A Retrospective Study on Coinfections, Antimicrobial Resistance, and Mortality Risk Among COVID-19 Patients (2020–2021) with Consideration of Long-COVID Outcomes
A Retrospective Study on Coinfections, Antimicrobial Resistance, and Mortality Risk Among COVID-19 Patients (2020–2021) with Consideration of Long-COVID Outcomes Open
Coinfections in COVID-19 patients can worsen disease severity by enhancing SARS-CoV-2 replication and proinflammatory cytokine levels. This study analyzes the characteristics of coinfected COVID-19 patients across the pandemic and their as…
View article: Comparative Analysis of Small Nerve Fiber Density in Fibromyalgia Syndrome and Small Fiber Neuropathy
Comparative Analysis of Small Nerve Fiber Density in Fibromyalgia Syndrome and Small Fiber Neuropathy Open
Background/Objectives: Fibromyalgia syndrome is commonly associated with reduced intraepidermal nerve fiber density (IENFD), as assessed by skin biopsy, a finding referred to as small fiber pathology (SFP-FMG). The clinical significance of…
View article: Classic pathway persistent complement activation is associated with specific symptoms in individuals with post–COVID-19 condition: A case-control study
Classic pathway persistent complement activation is associated with specific symptoms in individuals with post–COVID-19 condition: A case-control study Open
View article: Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study Open
Introduction Migraine is a primary headache showing a multifactorial component that includes altered pain processing, psychological/emotional problems, neurocognitive and executive function deficits, all with a possible genetic association…
View article: Effect of Intradermal Morphine on Histaminergic and Non‐Histaminergic Itch: A Randomised, Single‐Blinded, Human Study
Effect of Intradermal Morphine on Histaminergic and Non‐Histaminergic Itch: A Randomised, Single‐Blinded, Human Study Open
Itch can be a side‐effect of drugs like opioids, with prevalence depending on the route of administration. This study aimed to investigate if morphine (1) induced itch and neurogenic inflammation after intradermal injection and (2) modulat…
View article: The Role of Peripheral N‐Methyl‐D‐Asparate (<scp>NMDA</scp>) Receptors in Itch and Pain: A Narrative Review
The Role of Peripheral N‐Methyl‐D‐Asparate (<span>NMDA</span>) Receptors in Itch and Pain: A Narrative Review Open
Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Eme…
View article: Antagonizing TRPA1 receptors reduces the BAM8-22-induced itch in humans
Antagonizing TRPA1 receptors reduces the BAM8-22-induced itch in humans Open
Introduction: In most chronic itch conditions, antihistamines are ineffective, highlighting the necessity to study the mechanisms of non-histaminergic itch to develop new treatments. Polymodal C-fibers, transmitting non-histaminergic itch,…
View article: Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled Trial
Pain Mechanisms and Psychosocial Variables in Patients With Chronic Pain After Total Knee Arthroplasty: Secondary Analysis From a Randomised Controlled Trial Open
Introduction Chronic pain after total knee arthroplasty (TKA) affects approx. 15%–20% of patients undergoing surgery. It is largely unexplained why some patients develop chronic pain after TKA, but several factors, e.g., central pain mecha…
View article: Intravenous Administration of Remdesivir at the Acute Phase of SARS-CoV-2 Infection Is Associated with a Lower Prevalence of Post-COVID-19 Pain
Intravenous Administration of Remdesivir at the Acute Phase of SARS-CoV-2 Infection Is Associated with a Lower Prevalence of Post-COVID-19 Pain Open
Background/Objective: Evidence suggests that the administration of antivirals at the acute phase of SARS-CoV-2 infection is associated with lower COVID-19 severity, accordingly, the administration of antivirals at the acute phase of the in…
View article: Predictive Ability of Previous Pain and Disease Conditions on the Presentation of Post‐<scp>COVID</scp> Pain in a Danish Cohort of Adult <scp>COVID</scp>‐19 Survivors
Predictive Ability of Previous Pain and Disease Conditions on the Presentation of Post‐<span>COVID</span> Pain in a Danish Cohort of Adult <span>COVID</span>‐19 Survivors Open
Background Even though many post‐COVID pain risk factors have been identified, little is known about the predictive profiles of these risk factors for the development of post‐COVID pain. Methods Data was collected from two separate questio…
View article: Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study
Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study Open
Background Conditioned pain modulation (CPM) is considered a human proxy for descending inhibitory pain pathways. However, there is wide variation in the CPM response described in the literature and ongoing debate about its utility. Method…
View article: Expert Consensus on Dry Needling Practices for Headache: An International Delphi Study Protocol
Expert Consensus on Dry Needling Practices for Headache: An International Delphi Study Protocol Open
Background: Dry needling is increasingly utilized by clinicians in the treatment of patients with headaches. Although current evidence supports the use of dry needling for reducing headache pain, needling approaches are inconsistent among …
View article: DNA Salivary Methylation Levels of the ACE2 Promoter Are Not Related to ACE2 (rs2285666 and rs2074192), TMPRSS2 (rs12329760 and rs2070788) and ACE1 rs1799752 Polymorphisms in COVID-19 Survivors with Post-COVID-19 Condition
DNA Salivary Methylation Levels of the ACE2 Promoter Are Not Related to ACE2 (rs2285666 and rs2074192), TMPRSS2 (rs12329760 and rs2070788) and ACE1 rs1799752 Polymorphisms in COVID-19 Survivors with Post-COVID-19 Condition Open
Genetics and epigenetics are mechanisms proposed for explaining post-COVID-19 condition. This secondary analysis aimed to investigate if DNA methylation levels of the ACE2 promoter are different depending on the genotype of five COVID-19-r…
View article: Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes
Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes Open
Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and…
View article: Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes
Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes Open
Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and…
View article: Cut‐Off Values Able to Identify Migraine Patients With Increased Pressure‐Pain Sensitivity Independent of the Migraine Cycle Through a Single Assessment: A Secondary Analysis of a Multicentre, Cross‐Sectional, Observational Study
Cut‐Off Values Able to Identify Migraine Patients With Increased Pressure‐Pain Sensitivity Independent of the Migraine Cycle Through a Single Assessment: A Secondary Analysis of a Multicentre, Cross‐Sectional, Observational Study Open
Aim Identify values that could predict the presence of increased pressure‐pain sensitivity independent of the migraine cycle through a single assessment. Methods This was a secondary analysis of a previous study in which 198 episodic and c…
View article: Effect of Experimental Pain and Visual Feedback on the Accuracy and Precision of Knee Joint Position Sense
Effect of Experimental Pain and Visual Feedback on the Accuracy and Precision of Knee Joint Position Sense Open
Objective: To investigate the effects of experimental pain and visual feedback on the accuracy and precision of knee joint position sense following a period of motor training. Methods: Forty healthy young subjects (age: 24.5 ± 3.6 years ol…
View article: Changes in spatial bodily pain distribution one year after benign hysterectomy with emphasis on prevalence and risk factors for de novo and persistent pelvic pain- a prospective longitudinal multicenter study
Changes in spatial bodily pain distribution one year after benign hysterectomy with emphasis on prevalence and risk factors for de novo and persistent pelvic pain- a prospective longitudinal multicenter study Open
View article: Pain‐related impairment in daily activities after lung cancer surgery: A 1‐year prospective cohort study
Pain‐related impairment in daily activities after lung cancer surgery: A 1‐year prospective cohort study Open
Background Persistent postsurgical pain (PPSP) following thoracic surgery affects 40%–60% of patients undergoing lung resection due to malignancies. Postoperative pain‐related symptoms are common, leading to limitations in activities of da…
View article: Pain profiles and variability in temporal summation of pain and conditioned pain modulation in pain‐free individuals and patients with low back pain, osteoarthritis, and fibromyalgia
Pain profiles and variability in temporal summation of pain and conditioned pain modulation in pain‐free individuals and patients with low back pain, osteoarthritis, and fibromyalgia Open
Background Pain profiles (e.g. pro‐ and anti‐nociceptive) can be developed using quantitative sensory testing (QST) but substantial variability exists. This study describes the variability in temporal summation of pain (TSP) and conditione…
View article: Phenylephrine, an α1–adrenoceptor agonist, inhibits conditioned pain modulation in healthy humans
Phenylephrine, an α1–adrenoceptor agonist, inhibits conditioned pain modulation in healthy humans Open
The mechanism involved in conditioned pain modulation (CPM), a phenomenon wherein pain is controlled by heterotopic conditioning stimuli (CS), remains unclear in humans and involves a delicate balance between inhibition and excitation. The…
View article: Organization to Move Pain Education in Bangladesh
Organization to Move Pain Education in Bangladesh Open
“Pain medicine” is a discipline within the field of medicine that is concerned with the prevention of pain and the evaluation, treatment, and rehabilitation of persons in pain. Suboptimal management of pain is still an overgrown concern wo…
View article: Editorial: Updating long COVID: mechanisms, risk factors, and treatment
Editorial: Updating long COVID: mechanisms, risk factors, and treatment Open
View article: Diabetic Peripheral Neuropathy: Emerging Treatments of Neuropathic Pain and Novel Diagnostic Methods
Diabetic Peripheral Neuropathy: Emerging Treatments of Neuropathic Pain and Novel Diagnostic Methods Open
Background: Diabetic peripheral neuropathy (DPN) is a prevalent and debilitating complication of diabetes, often leading to severe neuropathic pain. Although other diabetes-related complications have witnessed a surge of emerging treatment…