Lars Melholt Rasmussen
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View article: Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial
Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial Open
Despite reduction in dp-ucMGP, high-dose vitamin K2 and D3 supplementation did not affect EAT, PCAT or systemic inflammation over 24 months. Alternative strategies may be needed to target inflammatory pathways in cardiovascular disease pre…
View article: From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics
From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics Open
View article: Mutational landscape of atherosclerotic plaques reveals large clonal cell populations
Mutational landscape of atherosclerotic plaques reveals large clonal cell populations Open
The notion of clonal cell populations in human atherosclerosis has been suggested but not demonstrated. Somatic mutations are used to define cellular clones in tumors. Here, we characterized the mutational landscape of human carotid plaque…
View article: Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation
Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation Open
Aims Abdominal aortic aneurysm (AAA) is a life-threatening condition where inflammation plays a key role. Currently, AAA treatment relies exclusively on surgical interventions, and no guideline drug therapy to prevent aneurysm growth or ru…
View article: Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms
Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms Open
Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by the weakening and dilation of the abdominal aorta. Few diagnostic biomarkers have been proposed for this condition. We performed mass spectrometry-based prote…
View article: Coronary artery calcification score and 19 biomarkers on cardiovascular events; a 10-year follow-up DanRisk substudy
Coronary artery calcification score and 19 biomarkers on cardiovascular events; a 10-year follow-up DanRisk substudy Open
View article: The pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaques
The pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaques Open
This study provides evidence for the presence of enzymatically active PAPP-A in atherosclerotic plaques and underscores the need for further investigating potential beneficial effects associated with targeting PAPP-A in atherosclerotic car…
View article: Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis
Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis Open
Aims Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased a…
View article: Corrigendum: Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression
Corrigendum: Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression Open
[This corrects the article DOI: 10.3389/fcvm.2022.942342.].
View article: A Carrier-Based Quantitative Proteomics Method Applied to Biomarker Discovery in Pericardial Fluid
A Carrier-Based Quantitative Proteomics Method Applied to Biomarker Discovery in Pericardial Fluid Open
View article: User-defined outcomes of the Danish cardiovascular screening (DANCAVAS) trial: A post hoc analyses of a population-based, randomised controlled trial
User-defined outcomes of the Danish cardiovascular screening (DANCAVAS) trial: A post hoc analyses of a population-based, randomised controlled trial Open
Background The Danish cardiovascular screening (DANCAVAS) trial, a nationwide trial designed to investigate the impact of cardiovascular screening in men, did not decrease all-cause mortality, an outcome decided by the investigators. Howev…
View article: A Mass Spectrometry-Based Proteome Study of Twin Pairs Discordant for Incident Acute Myocardial Infarction within Three Years after Blood Sampling Suggests Novel Biomarkers
A Mass Spectrometry-Based Proteome Study of Twin Pairs Discordant for Incident Acute Myocardial Infarction within Three Years after Blood Sampling Suggests Novel Biomarkers Open
Acute myocardial infarction (AMI) is a major cause of mortality and morbidity worldwide, yet biomarkers for AMI in the short- or medium-term are lacking. We apply the discordant twin pair design, reducing genetic and environmental confound…
View article: Safety and Efficacy Report for the Use of Poly-4-Hydroxybutyrate as a Retropubic Mid-Urethral Sling (MUS) for Stress Urinary Incontinence: A Prospective 24 Months Follow-Up of New Poly-4-Hydroxybutyrate TephaFlex SUI Bioresorbable MUS
Safety and Efficacy Report for the Use of Poly-4-Hydroxybutyrate as a Retropubic Mid-Urethral Sling (MUS) for Stress Urinary Incontinence: A Prospective 24 Months Follow-Up of New Poly-4-Hydroxybutyrate TephaFlex SUI Bioresorbable MUS Open
Preliminary evidence suggests that a sling made of P4HB can be safely used for MUS procedures and could be an alternative for permanent polypropylene slings in patients that prefer the use of nonpermanent material.
View article: Coronary artery calcification score and 19 biomarkers on cardiovascular events; a 10-year follow-up DanRisk substudy
Coronary artery calcification score and 19 biomarkers on cardiovascular events; a 10-year follow-up DanRisk substudy Open
Background SCORE2 is recommended for the estimation of the 10-year risk of cardiovascular disease (CVD), and guideance of medical therapy. However, the prediction is deficient. Coronary artery calcification (CAC) score has been proven to i…
View article: Effects of Vitamin K2 and D Supplementation on Coronary Artery Disease in Men
Effects of Vitamin K2 and D Supplementation on Coronary Artery Disease in Men Open
View article: Single-incision sling operations for urinary incontinence in women
Single-incision sling operations for urinary incontinence in women Open
Single-incision sling operations have been extensively researched in randomised controlled trials. They may be as effective as retropubic slings and are as effective as transobturator slings for subjective cure or improvement of stress uri…
View article: Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target Open
View article: The Non-syndromic Ascending Thoracic Aorta in a Population-based Setting of 60–74-Year-Olds: A Five-year Prospective Cohort Study from the Multi-center, Randomized DANCAVAS Screening Trials
The Non-syndromic Ascending Thoracic Aorta in a Population-based Setting of 60–74-Year-Olds: A Five-year Prospective Cohort Study from the Multi-center, Randomized DANCAVAS Screening Trials Open
Background: Prospective data on the ascending thoracic aorta are lacking. This study aimed to estimate growth rates and predictors of adverse aortic events (AAE).
View article: Platelet Aggregation Is Not Altered in Men with Aortic Aneurysms
Platelet Aggregation Is Not Altered in Men with Aortic Aneurysms Open
What is the clinical question being addressed? Ascending and abdominal aortic dilations have been associated with increased platelet activation response suggesting platelets as a potential medical target. • What is the main finding? This s…
View article: Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial
Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial Open
Introduction Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and cardiovascular mortality. Supplementation with vitamin K2 and D3 has been suggested to have a prote…
View article: The effect of CO<sub>2</sub> laser therapy on vaginal microcirculatory parameters in an animal model for genitourinary syndrome of menopause
The effect of CO<sub>2</sub> laser therapy on vaginal microcirculatory parameters in an animal model for genitourinary syndrome of menopause Open
Background Vaginal laser therapy for the treatment of genitourinary syndrome of menopause (GSM) has been introduced to the market with limited (pre)clinical and experimental evidence supporting its efficacy. It is suggested that vaginal la…
View article: Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis
Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis Open
Aims Blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors of cardiovascular diseases. This study tested whether and how eosinophils and ECP contribute to vascular calcification and atherogenesis. Meth…
View article: Nicotine Administration Augments Abdominal Aortic Aneurysm Progression in Rats
Nicotine Administration Augments Abdominal Aortic Aneurysm Progression in Rats Open
Inflammation and elastin degradation are key hallmarks in the pathogenesis of abdominal aortic aneurysms (AAAs). It has been acknowledged that activation of alpha7 nicotinic acetylcholine receptors (α7nAChRs) attenuates inflammation, terme…
View article: Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause
Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause Open
Objective To evaluate the effect of iatrogenic menopause on the physiology of the vagina of the ewe and to evaluate if vaginal changes in ewes can be translated to women with genitourinary syndrome of menopause (GSM). Methods Preclinical r…
View article: The association between diabetes and abdominal aortic aneurysms in men: results of two Danish screening studies, a systematic review, and a meta-analysis of population-based screening studies
The association between diabetes and abdominal aortic aneurysms in men: results of two Danish screening studies, a systematic review, and a meta-analysis of population-based screening studies Open
View article: Ccn2 deficiency causes smooth muscle cell de-differentiation and severe atherosclerosis in hyperlipidemic mice
Ccn2 deficiency causes smooth muscle cell de-differentiation and severe atherosclerosis in hyperlipidemic mice Open
Cellular communication network factor 2 (CCN2/CTGF) is a matricellular protein with an established role in fibrotic diseases and cancers, and therapies targeting CCN2 is currently in Phase II and III clinical trials for idiopathic pulmonar…
View article: Development of a minimal invasive surgical procedure for stress urinary incontinence
Development of a minimal invasive surgical procedure for stress urinary incontinence Open
Stress urinary incontinence (SUI) is a prevalent and bothersome condition. In patients with moderate to severe SUI, midurethral sling surgery, as compared to first line physiotherapy, results in higher rates of subjective improvement and o…
View article: A targeted multiplex mass spectrometry method for quantitation of abundant matrix and cellular proteins in formalin-fixed paraffin embedded arterial tissue
A targeted multiplex mass spectrometry method for quantitation of abundant matrix and cellular proteins in formalin-fixed paraffin embedded arterial tissue Open
View article: Serum keratin‐18 detects hepatic inflammation and predicts progression in compensated alcohol‐associated liver disease
Serum keratin‐18 detects hepatic inflammation and predicts progression in compensated alcohol‐associated liver disease Open
Alcohol‐associated liver fibrosis accumulates over decades, driven by hepatic inflammation and cell death. We investigated the diagnostic accuracy of keratin‐18 degradation, measured using serum M30 and M65 levels, and the ActiTest for hep…
View article: Treatment of Vitamin K Deficiency in Hemodialysis Patients – A Pilot Study Comparing Menaquinone-7 Tablets and a Vitamin K Rich Diet
Treatment of Vitamin K Deficiency in Hemodialysis Patients – A Pilot Study Comparing Menaquinone-7 Tablets and a Vitamin K Rich Diet Open
A daily MK-7 supplement for 6 weeks lowered dp-ucMGP and ucOC significantly, while a vitamin K rich diet was not able to induce any significant effect. Boiled broccoli maintains a reasonable content of phylloquinone while potassium is extr…