Lars S. Rasmussen
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View article: Effects of Hyperoxia and Antioxidants on Mortality, Hospital Admissions, and Myocardial Infarction After Noncardiac Surgery: 1‐Year Follow‐Up of a Randomized Controlled Trial
Effects of Hyperoxia and Antioxidants on Mortality, Hospital Admissions, and Myocardial Infarction After Noncardiac Surgery: 1‐Year Follow‐Up of a Randomized Controlled Trial Open
Background Perioperative hyperoxia may be associated with increased long‐term mortality, whereas perioperative antioxidants may be associated with reduced long‐term mortality. This study aimed to determine if high perioperative inspiratory…
View article: Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial
Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial Open
Background Several drugs may be used to minimize pain during nasal intubation in awake patients. We hypothesized that the analgesic effect of cocaine would be at least as good (non‐inferior) as that of lidocaine with xylometazoline rated a…
View article: Cocaine to prevent bleeding during nasotracheal intubation: A systematic review
Cocaine to prevent bleeding during nasotracheal intubation: A systematic review Open
Background Nasotracheal intubation is associated with a risk of epistaxis. Decongestion of the nasal mucosa reduces the risk of epistaxis, and different vasoconstrictors may be used. Cocaine has both decongestive and analgesic properties, …
View article: Oxidative stress in trauma patients receiving a restrictive or liberal oxygen strategy – A sub-study of the TRAUMOX2 trial
Oxidative stress in trauma patients receiving a restrictive or liberal oxygen strategy – A sub-study of the TRAUMOX2 trial Open
In this sub-study of the TRAUMOX2 trial, no significant differences were found in biomarkers of oxidative stress between a restrictive oxygen strategy and liberal oxygen strategy in adult trauma patients.
View article: Intubating conditions during rapid sequence induction with either rocuronium or suxamethonium in elderly patients. A randomised study
Intubating conditions during rapid sequence induction with either rocuronium or suxamethonium in elderly patients. A randomised study Open
Background During rapid sequence induction, either rocuronium 1.0 mg kg −1 or suxamethonium 1.0 mg kg −1 can be administered to facilitate endotracheal intubation. We hypothezised that rocuronium provided a larger proportion of excellent i…
View article: Early Restrictive vs Liberal Oxygen for Trauma Patients
Early Restrictive vs Liberal Oxygen for Trauma Patients Open
Importance Early administration of supplemental oxygen for all severely injured trauma patients is recommended, but liberal oxygen treatment has been associated with increased risk of death and respiratory complications. Objective To deter…
View article: Severe traumatic injury is associated with profound changes in DNA methylation
Severe traumatic injury is associated with profound changes in DNA methylation Open
Whether DNA methylation changes follow human physical trauma is uncertain. We aimed to investigate if severe trauma was associated with DNA methylation changes. In a prospective, observational, clinical study, we included severely injured …
View article: Detection of cocaine 24 h after administration before nasotracheal intubation
Detection of cocaine 24 h after administration before nasotracheal intubation Open
Background Cocaine may be applied to decongest the nasal mucosa before nasotracheal intubation, but patients risk a criminal offence if cocaine is detected when patients drive a car shortly after surgery. We aimed to evaluate whether benzo…
View article: Cocaine versus xylometazoline to prevent epistaxis after nasotracheal intubation: A randomized trial
Cocaine versus xylometazoline to prevent epistaxis after nasotracheal intubation: A randomized trial Open
Background Nasotracheal intubation is associated with a risk of epistaxis. Several drugs, including cocaine and xylometazoline may be used as decongestants prior to nasotracheal intubation to prevent this. We hypothesized that xylometazoli…
View article: Shortened time to neuromuscular recovery with lower doses of rocuronium in elderly patients
Shortened time to neuromuscular recovery with lower doses of rocuronium in elderly patients Open
INTRODUCTION. The effect of neuromuscular blocking agents may be reversed by administration of neostigmine, when two twitches are present using train-of-four (TOF) stimulation. However, in elderly patients, limited data are available about…
View article: Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients
Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients Open
Background The neuromuscular blocking agent mivacurium can be used during anesthesia to facilitate tracheal intubation. Data on onset time, duration of action, and effect on intubating conditions in patients 80 years and older are however …
View article: Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study
Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study Open
Background Suxamethonium is hydrolysed by butyrylcholinesterase (BChE) and a low BChE activity can result in a prolonged duration of action of suxamethonium. The BChE activity is reduced during pregnancy and postpartum period by up to 33%.…
View article: <scp>Intravenous MELAtonin</scp> for prevention of Postoperative Agitation and Emergence Delirium in children (<scp>MELA‐PAED</scp>): A protocol and statistical analysis plan for a randomized clinical trial
<span>Intravenous MELAtonin</span> for prevention of Postoperative Agitation and Emergence Delirium in children (<span>MELA‐PAED</span>): A protocol and statistical analysis plan for a randomized clinical trial Open
Background Emergence agitation and delirium in children remain a common clinical challenge in the post‐anesthetic care unit. Preoperative oral melatonin has been suggested as an effective preventive drug with a favorable safety profile. Th…
View article: Reply to Hall et al. Comment on “Dinesen et al. Diphoterine for Chemical Burns of the Skin: A Systematic Review. Eur. Burn J. 2023, 4, 55–68”
Reply to Hall et al. Comment on “Dinesen et al. Diphoterine for Chemical Burns of the Skin: A Systematic Review. Eur. Burn J. 2023, 4, 55–68” Open
We thank Hall et al. [...]
View article: Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins
Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins Open
Importance Immediate consequences of trauma include a rapid and immense activation of the immune system, whereas long-term outcomes include premature death, physical disability, and reduced workability. Objective To investigate if moderate…
View article: Comparing restrictive versus liberal oxygen strategies for trauma patients: The <scp>TRAUMOX2</scp> trial—Statistical analysis plan
Comparing restrictive versus liberal oxygen strategies for trauma patients: The <span>TRAUMOX2</span> trial—Statistical analysis plan Open
Background The international advanced trauma life support guidelines recommend that all severely injured trauma patients receive supplemental oxygen based on very limited evidence. The TRAUMOX2 trial randomises adult trauma patients to a r…
View article: Transcutaneous carbon dioxide monitoring during prolonged apnoea with high‐flow nasal oxygen
Transcutaneous carbon dioxide monitoring during prolonged apnoea with high‐flow nasal oxygen Open
Background The duration of apnoeic oxygenation with high‐flow nasal oxygen is limited by hypercapnia and acidosis and monitoring of arterial carbon dioxide level is therefore essential. We have performed a study in patients undergoing prol…
View article: Diphoterine for Chemical Burns of the Skin: A Systematic Review
Diphoterine for Chemical Burns of the Skin: A Systematic Review Open
The incidence of chemical burns appears to be increasing. Diphoterine is an amphoteric, chelating, polyvalent solution used for the decontamination of chemical splashes. In this systematic review, we aimed to assess the effect of diphoteri…
View article: Intra‐operative blood transfusion in elderly patients on antithrombotic therapy
Intra‐operative blood transfusion in elderly patients on antithrombotic therapy Open
Background Many elderly patients are receiving antithrombotics, which may increase intra‐operative blood loss. We aimed to assess whether chronic antithrombotic therapy was associated with intra‐operative transfusion of packed red blood ce…
View article: Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study
Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study Open
Background: Procedural pain in burn patients continues to be a major problem. Frequently used analgesics, such as opioids, may have various side effects, including respiratory depression, nausea, and vomiting. Inhaled methoxyflurane has be…
View article: Comparison of onset time, duration of action, and intubating conditions after cisatracurium 0.15 mg/kg in young and elderly patients
Comparison of onset time, duration of action, and intubating conditions after cisatracurium 0.15 mg/kg in young and elderly patients Open
Introduction Tracheal intubation during anesthesia can be facilitated by the neuromuscular blocking agent cisatracurium. However, limited data exists about onset time, duration of action and effect on intubating conditions in elderly patie…
View article: Comparing restrictive versus liberal oxygen strategies for trauma patients — the TRAUMOX2 trial: protocol for a randomised clinical trial
Comparing restrictive versus liberal oxygen strategies for trauma patients — the TRAUMOX2 trial: protocol for a randomised clinical trial Open
Introduction Supplemental oxygen is commonly used in trauma patients, although it may lead to hyperoxaemia that has been associated with pulmonary complications and increased mortality. The primary objective of this trial, TRAUMOX2, is to …
View article: Time to CT scan for patients with acute severe neurological symptoms: a quality assurance study
Time to CT scan for patients with acute severe neurological symptoms: a quality assurance study Open
Emergent brain computed tomography (CT) scan allows for identification of patients presenting with acute severe neurological symptoms in whom medical and surgical interventions may be lifesaving. The aim of this study was to evaluate if ti…
View article: Rocuronium 0.3 or 0.9 mg/kg comparing onset time, duration of action, and intubating conditions in patients 80 years and older: A randomized study
Rocuronium 0.3 or 0.9 mg/kg comparing onset time, duration of action, and intubating conditions in patients 80 years and older: A randomized study Open
Background Limited data exist about the optimal dose of rocuronium for intubation in elderly patients. We hypothesized that rocuronium 0.9 mg/kg would lead to a shorter onset time than 0.3 mg/kg in patients above 80 years. Methods Thirty‐f…
View article: Agreement Between Standard and ICD-10-Based Injury Severity Scores
Agreement Between Standard and ICD-10-Based Injury Severity Scores Open
Using ICDPIC-R or ICD-AIS map to determine ISS is feasible, but limits of agreement were unacceptably wide. The agreement between ISS-TARN and ICDPIC-R was moderate for ISS above 15.