Lars Wilmes
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View article: Faecal transplantation from exuberant toddlers increases exploratory behaviour in rats
Faecal transplantation from exuberant toddlers increases exploratory behaviour in rats Open
Background Behavioural phenotypes have previously been transferred via faecal microbiota transplantation (FMT) from patients with psychiatric disorders to rodents. Studies indicate that the gut microbiota composition may be linked to certa…
View article: Nutritional interventions to counteract the detrimental consequences of early-life stress
Nutritional interventions to counteract the detrimental consequences of early-life stress Open
View article: Gut microbiota regulates stress responsivity via the circadian system
Gut microbiota regulates stress responsivity via the circadian system Open
Stress and circadian systems are interconnected through the hypothalamic-pituitary-adrenal (HPA) axis to maintain responses to external stimuli. Yet, the mechanisms of how such signals are orchestrated remain unknown. Here, we uncover the …
View article: Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress
Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress Open
Our study is the first to identify distinct phenotypes defined by susceptibility or resilience to gut-brain dysfunction induced by early life stress. The gut microbiota in early life shows sex-dependent alterations in each cluster that pre…
View article: The microbiome-gut-brain axis predicts vulnerability and resilience to early-life stress
The microbiome-gut-brain axis predicts vulnerability and resilience to early-life stress Open
View article: behavioural outcomes following early life stress: role of the microbiota-gut-brain axis in resilience and vulnerability
behavioural outcomes following early life stress: role of the microbiota-gut-brain axis in resilience and vulnerability Open
View article: Faecal transplantation from exuberant toddlers increases exploratory behaviour in juvenile rats: A FinnBrain Birth Cohort Study
Faecal transplantation from exuberant toddlers increases exploratory behaviour in juvenile rats: A FinnBrain Birth Cohort Study Open
View article: The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective Open
The physiological consequences of stress often manifest in the gastrointestinal tract. Traumatic or chronic stress is associated with widespread maladaptive changes throughout the gut, although comparatively little is known about the effec…
View article: Molecular changes in hippocampal energy metabolism in mice selectively bred for extremes in stress reactivity: Relevance of mitochondrial dysfunction for affective disorders
Molecular changes in hippocampal energy metabolism in mice selectively bred for extremes in stress reactivity: Relevance of mitochondrial dysfunction for affective disorders Open
Affective disorders, such as major depression, are frequently associated with metabolic disturbances involving mitochondria. Although dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis is known to alter energy metabolism, the p…
View article: Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome
Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome Open
Background The gastrointestinal microbiota has emerged as a key regulator of gut‐brain axis signalling with important implications for neurogastroenterology. There is continuous bidirectional communication between the gut and the brain fac…