Larysa V. Yuzefovych
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View article: OGG1 Preserves Endothelial-Dependent Vasodilation and Regulates the Frequency and Spatial Area of Endothelial Calcium Signals
OGG1 Preserves Endothelial-Dependent Vasodilation and Regulates the Frequency and Spatial Area of Endothelial Calcium Signals Open
Endothelial calcium dysregulation underlies impairments in endothelial-dependent vasodilation (EDV), contributing to vascular disease progression. Repletion of 8-oxoguanine DNA glycosylase (OGG1), an enzyme involved in base excision repair…
View article: Mitochondria-Targeted DNA Repair Glycosylase hOGG1 Protects Against HFD-Induced Liver Oxidative Mitochondrial DNA Damage and Insulin Resistance in OGG1-Deficient Mice
Mitochondria-Targeted DNA Repair Glycosylase hOGG1 Protects Against HFD-Induced Liver Oxidative Mitochondrial DNA Damage and Insulin Resistance in OGG1-Deficient Mice Open
8-oxoguanine DNA glycosylase-1 (OGG1) is a DNA glycosylase mediating the first step in base excision repair which removes 7,8-dihydro-8-oxoguanine (8-oxoG) and repairs oxidized nuclear and mitochondrial DNA. Previous studies showed that OG…
View article: Effect of Bariatric Surgery on Plasma Cell-Free Mitochondrial DNA, Insulin Sensitivity and Metabolic Changes in Obese Patients
Effect of Bariatric Surgery on Plasma Cell-Free Mitochondrial DNA, Insulin Sensitivity and Metabolic Changes in Obese Patients Open
While improvement of mitochondrial function after bariatric surgery has been demonstrated, there is limited evidence about the effects of bariatric surgery on circulatory cell-free (cf) mitochondrial DNA (mtDNA) and intracellular mtDNA abu…
View article: Supplementary Figures S1-S4 from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Supplementary Figures S1-S4 from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Representative images of each genotype of PyMT mice with mammary tumors obtained from 12-16-week old female (S1); Histological sections of the lungs from PyMT mice of different OGG1 genotypes (S2); OGG1 activity in mammary tumors isolated …
View article: Data from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Data from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Production of mitochondrial reactive oxygen species and integrity of mitochondrial DNA (mtDNA) are crucial in breast cancer progression and metastasis. Therefore, we evaluated the role of mtDNA damage in breast cancer by genetically modula…
View article: Supplementary Figure Legends from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Supplementary Figure Legends from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Legend for Supplementary Figures S1-S4.
View article: Supplementary Figure Legends from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Supplementary Figure Legends from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Legend for Supplementary Figures S1-S4.
View article: Supplementary Figures S1-S4 from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Supplementary Figures S1-S4 from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Representative images of each genotype of PyMT mice with mammary tumors obtained from 12-16-week old female (S1); Histological sections of the lungs from PyMT mice of different OGG1 genotypes (S2); OGG1 activity in mammary tumors isolated …
View article: Data from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Data from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Production of mitochondrial reactive oxygen species and integrity of mitochondrial DNA (mtDNA) are crucial in breast cancer progression and metastasis. Therefore, we evaluated the role of mtDNA damage in breast cancer by genetically modula…
View article: Correction: Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Correction: Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
In the original version of this article (1), there are errors in Figs. 2A and 2E. Specifically, in Fig. 2A, the Western blot image of the WT/TG panel partially overlaps with that of the KO/TG panel. In addition, the Southern blot image in …
View article: Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance
Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance Open
Cells damaged by mechanical or infectious injury release proinflammatory mitochondrial DNA (mtDNA) fragments into the circulation. We evaluated the relation between plasma levels of mtDNA fragments in obese type 2 diabetes mellitus (T2DM) …
View article: Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis Open
Production of mitochondrial reactive oxygen species and integrity of mitochondrial DNA (mtDNA) are crucial in breast cancer progression and metastasis. Therefore, we evaluated the role of mtDNA damage in breast cancer by genetically modula…
View article: A schematic model of the proposed links between palmitate-induced mtDNA damage, mitochondrial dysfunction and ROS production, ER stress, autophagy and IR in L6 myotubes.
A schematic model of the proposed links between palmitate-induced mtDNA damage, mitochondrial dysfunction and ROS production, ER stress, autophagy and IR in L6 myotubes. Open
A schematic model of the proposed links between palmitate-induced mtDNA damage, mitochondrial dysfunction and ROS production, ER stress, autophagy and IR in L6 myotubes.