Lasse Langholm
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View article: Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with crohn’s disease
Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with crohn’s disease Open
The biomarker PRO-C16 was associated with a stricturing disease phenotype, indicating that PRO-C16 may be a potential marker of intestinal fibrosis in CD, with the potential to aid in the clinical development of novel stromal-immune therap…
View article: Proteolytic degradation of Beta-Ig H3 (βigH3/TGFBI) can be quantified non-invasively in serum and predicts prognosis in patients with advanced pancreatic ductal adenocarcinoma
Proteolytic degradation of Beta-Ig H3 (βigH3/TGFBI) can be quantified non-invasively in serum and predicts prognosis in patients with advanced pancreatic ductal adenocarcinoma Open
The extracellular matrix (ECM) protein Beta-Ig H3 (βigH3, also known as transforming growth factor β induced protein (TGFBI)) is related to poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Proteolytic cleavage of βi…
View article: Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with Crohn’s disease
Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with Crohn’s disease Open
Background Fibrostenotic stricturing disease affects 30–50% of patients with Crohn’s disease (CD) leading to intestinal resection. Currently, there exists a great medical need to identify biomarkers related to fibrostenotic strictures for …
View article: Fibroblast Activation Protein (FAP)-Mediated Cleavage of Type III Collagen Reveals Serum Biomarker Potential in Non-Small Cell Lung Cancer and Spondyloarthritis
Fibroblast Activation Protein (FAP)-Mediated Cleavage of Type III Collagen Reveals Serum Biomarker Potential in Non-Small Cell Lung Cancer and Spondyloarthritis Open
Fibroblast activation protein (FAP) is a known promoter of tumor development and is associated with poor clinical outcome for various cancer types. Being specifically expressed in pathological conditions including multiple types of fibrosi…
View article: A serologically assessed neo-epitope biomarker of cellular fibronectin degradation is related to pulmonary fibrosis
A serologically assessed neo-epitope biomarker of cellular fibronectin degradation is related to pulmonary fibrosis Open
View article: Lot-to-Lot Variance in Immunoassays—Causes, Consequences, and Solutions
Lot-to-Lot Variance in Immunoassays—Causes, Consequences, and Solutions Open
Immunoassays, which have gained popularity in clinical practice and modern biomedical research, play an increasingly important role in quantifying various analytes in biological samples. Despite their high sensitivity and specificity, as w…
View article: Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis
Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis Open
Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon is transforming growth factor beta (TGF-β). TGF-β is produced i…
View article: Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease
Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease Open
We developed a competitive ELISA for serological detection of HSP47-C. The study supports HSP47 as a potential marker of liver fibrosis in ALD.
View article: Noninvasive prognostic biomarker potential of quantifying the propeptides of <scp>Type XI</scp> collagen alpha‐1 chain (<scp>PRO‐C11</scp>) in patients with pancreatic ductal adenocarcinoma
Noninvasive prognostic biomarker potential of quantifying the propeptides of <span>Type XI</span> collagen alpha‐1 chain (<span>PRO‐C11</span>) in patients with pancreatic ductal adenocarcinoma Open
Type XI collagen has been associated with tumor fibrosis and aggressiveness in patients with pancreatic ductal adenocarcinoma (PDAC). The propeptide on Type XI collagen is released into the circulation after proteolytic processing at eithe…
View article: Combining biomarkers of clot resolution and alveolar basement membrane destruction predicts mortality in the ECLIPSE COPD cohort
Combining biomarkers of clot resolution and alveolar basement membrane destruction predicts mortality in the ECLIPSE COPD cohort Open
View article: Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort
Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort Open
Background Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI collagen has been id…
View article: <p>Increased von Willebrand Factor Processing in COPD, Reflecting Lung Epithelium Damage, Is Associated with Emphysema, Exacerbations and Elevated Mortality Risk</p>
Increased von Willebrand Factor Processing in COPD, Reflecting Lung Epithelium Damage, Is Associated with Emphysema, Exacerbations and Elevated Mortality Risk Open
Lasse L Langholm,1,2 Sarah Rank Rønnow,1,3 Jannie MB Sand,1 Diana Julie Leeming,1 Ruth Tal-Singer,4 Bruce E Miller,4 Jørgen Vestbo,5 Morten A Karsdal,1 Tina Manon-Jensen1 1Nordic Bioscience A/S, Herlev, Denmark; 2Univ…
View article: End-product of fibrinogen is elevated in emphysematous chronic obstructive pulmonary disease and is predictive of mortality in the ECLIPSE cohort
End-product of fibrinogen is elevated in emphysematous chronic obstructive pulmonary disease and is predictive of mortality in the ECLIPSE cohort Open
View article: Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort
Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort Open
View article: Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort
Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort Open
Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to…
View article: P301 A serological biomarker of type VIII collagen that contains the anti-angiogenic signalling molecule, vastatin, is associated with the extension of disease in ulcerative colitis
P301 A serological biomarker of type VIII collagen that contains the anti-angiogenic signalling molecule, vastatin, is associated with the extension of disease in ulcerative colitis Open
Ulcerative colitis (UC) is characterised by superficial inflammation that starts in the rectum and can extend proximally to affect the entire colon. Endoscopy is used to diagnose patients in terms of extension of disease; however, this is …
View article: Platelet activation by activated von Willebrand factor is a marker of intestinal wound healing in patients with Crohn's disease
Platelet activation by activated von Willebrand factor is a marker of intestinal wound healing in patients with Crohn's disease Open
View article: P265 Platelet activation by activated von Willebrand factor is a marker of intestinal wound healing in patients with Crohn’s disease
P265 Platelet activation by activated von Willebrand factor is a marker of intestinal wound healing in patients with Crohn’s disease Open
Background Crohn’s disease (CD) is a chronic inflammatory condition of the intestinal tract resulting in ongoing tissue damage and impaired wound healing. The reduced ability of CD patients to heal damaged tissue is reflected by the tenden…
View article: Single Site Suppressors of a Fission Yeast Temperature-Sensitive Mutant in cdc48 Identified by Whole Genome Sequencing
Single Site Suppressors of a Fission Yeast Temperature-Sensitive Mutant in cdc48 Identified by Whole Genome Sequencing Open
The protein called p97 in mammals and Cdc48 in budding and fission yeast is a homo-hexameric, ring-shaped, ubiquitin-dependent ATPase complex involved in a range of cellular functions, including protein degradation, vesicle fusion, DNA rep…