Albert-Ĺaszló Barabási
YOU?
Author Swipe
View article: Surface Optimisation Governs the Local Design of Physical Networks
Surface Optimisation Governs the Local Design of Physical Networks Open
The brain's connectome and the vascular system are examples of physical networks whose tangible nature influences their structure, layout, and ultimately their function. The material resources required to build and maintain these networks …
View article: Logarithmic kinetics and bundling in random packings of elongated 3D physical links
Logarithmic kinetics and bundling in random packings of elongated 3D physical links Open
We explore the impact of excluded volume interactions on the local assembly of linear physical networks, where nodes are spheres and links are rigid cylinders with varying length. To focus on the effect of elongated links, we introduce a m…
View article: Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells
Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells Open
Somatic mutations accumulate with age in human tissues. Clonal amplification of some mutations causes cancers and other diseases. However, it is unclear if random mutation accumulation affects cellular function without clonal amplification…
View article: Quantifying the impact of biobanks and cohort studies
Quantifying the impact of biobanks and cohort studies Open
Biobanks advance biomedical and clinical research by collecting and offering data and biological samples for numerous studies. However, the impact of these repositories varies greatly due to differences in their purpose, scope, governance,…
View article: Physical Network Constraints Define the Multiplicative Architecture of the Brain’s Connectome
Physical Network Constraints Define the Multiplicative Architecture of the Brain’s Connectome Open
The brain has long been conceptualized as a network of neurons connected by synapses. However, attempts to describe the connectome using established network science models have yielded conflicting outcomes, leaving the architecture of neur…
View article: Transformers Enhance the Predictive Power of Network Medicine
Transformers Enhance the Predictive Power of Network Medicine Open
Background Self-attention mechanisms and token embeddings behind transformers allow the extraction of complex patterns from large datasets, and enhance the predictive power over traditional machine learning models. Yet, being trained to ma…
View article: Enhancing the Accuracy of Network Medicine Through Understanding the Impact of Sample Size in Gene Co-expression Networks
Enhancing the Accuracy of Network Medicine Through Understanding the Impact of Sample Size in Gene Co-expression Networks Open
Network medicine relies on RNA sequencing to infer gene co-expression networks, which are crucial to identify functional gene clusters and gene regulatory interactions, and offer a deeper understanding of disease phenotypes and drug mechan…
View article: The origin, consequence, and visibility of criticism in science
The origin, consequence, and visibility of criticism in science Open
Critique between peers plays a vital role in the production of scientific knowledge. Yet, there is limited empirical evidence on the origins of criticism, its effects on the papers and individuals involved, and its visibility within the sc…
View article: Human-AI coevolution
Human-AI coevolution Open
In Press, Pre-proof
View article: NetMedPy: A Python package for Large-Scale Network Medicine Screening
NetMedPy: A Python package for Large-Scale Network Medicine Screening Open
Summary Network medicine leverages the quantification of information flow within sub-cellular networks to elucidate disease etiology and comorbidity, as well as to predict drug efficacy and identify potential therapeutic targets. However, …
View article: A Network-Based Framework to Discover Treatment-Response–Predicting Biomarkers for Complex Diseases
A Network-Based Framework to Discover Treatment-Response–Predicting Biomarkers for Complex Diseases Open
The potential of precision medicine to transform complex autoimmune disease treatment is often challenged by limited data availability and inadequate sample size when compared with the number of molecular features found in high-throughput …
View article: Quantifying the Impact of Biobanks and Cohort Studies
Quantifying the Impact of Biobanks and Cohort Studies Open
Biobanks advance biomedical and clinical research by collecting and offering data and biological samples for numerous studies. However, the impact of these repositories varies greatly due to differences in their purpose, scope, governance,…
View article: Improving the performance and interpretability on medical datasets using graphical ensemble feature selection
Improving the performance and interpretability on medical datasets using graphical ensemble feature selection Open
Motivation A major hindrance towards using Machine Learning (ML) on medical datasets is the discrepancy between a large number of variables and small sample sizes. While multiple feature selection techniques have been proposed to avoid the…
View article: Negative Selection Allows DNA Mismatch Repair-Deficient Mouse Fibroblasts<i>In Vitro</i>to Tolerate High Levels of Somatic Mutations
Negative Selection Allows DNA Mismatch Repair-Deficient Mouse Fibroblasts<i>In Vitro</i>to Tolerate High Levels of Somatic Mutations Open
Summary Substantial numbers of somatic mutations have been found to accumulate with age in different human tissues. Clonal cellular amplification of some of these mutations can cause cancer and other diseases. However, it is as yet unclear…
View article: Hidden citations obscure true impact in science
Hidden citations obscure true impact in science Open
References, the mechanism scientists rely on to signal previous knowledge, lately have turned into widely used and misused measures of scientific impact. Yet, when a discovery becomes common knowledge, citations suffer from obliteration by…
View article: Enhancing the accuracy of Network Medicine through understanding the impact of sample size in gene co-expression networks
Enhancing the accuracy of Network Medicine through understanding the impact of sample size in gene co-expression networks Open
Network Medicine relies on RNA sequencing to infer gene co-expression networks, which are crucial to identify functional gene clusters and gene regulatory interactions, and offer a deeper understanding of disease phenotypes and drug mechan…
View article: iGEM: a model system for team science and innovation
iGEM: a model system for team science and innovation Open
This dataset is extracted from the international Genetically Engineered Machine (iGEM) competition between years 2008 and 2018, and can be used as a model system for studying team science and innovation. It is described at length in this a…
View article: Mapping philanthropic support of science
Mapping philanthropic support of science Open
While philanthropic support for science has increased in the past decade, there is limited quantitative knowledge about the patterns that characterize it and the mechanisms that drive its distribution. Here, we map philanthropic funding to…
View article: Human Mobility in the Metaverse
Human Mobility in the Metaverse Open
The metaverse promises a shift in the way humans interact with each other, and with their digital and physical environments. The lack of geographical boundaries and travel costs in the metaverse prompts us to ask if the fundamental laws th…
View article: Measuring Entanglement in Physical Networks
Measuring Entanglement in Physical Networks Open
The links of a physical network cannot cross, which often forces the network layout into non-optimal entangled states. Here we define a network fabric as a two-dimensional projection of a network and propose the average crossing number as …
View article: Genomics and phenomics of body mass index reveals a complex disease network
Genomics and phenomics of body mass index reveals a complex disease network Open
Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunit…
View article: An Overivew of the Science of Success
An Overivew of the Science of Success Open
The goal of the Science of Success is to explore in a quantitative manner the processes and behaviors through which some individuals attain success. The central tenet of the discipline is the distinction between performance, an individual …
View article: Logarithmic kinetics and bundling in physical networks
Logarithmic kinetics and bundling in physical networks Open
We explore the impact of volume exclusion on the local assembly of linear physical networks, where nodes and links are hard-core rigid objects. To do so, we introduce a minimal 3D model that helps us zoom into confined regions of these net…
View article: A network-based normalized impact measure reveals successful periods of scientific discovery across disciplines
A network-based normalized impact measure reveals successful periods of scientific discovery across disciplines Open
The impact of a scientific publication is often measured by the number of citations it receives from the scientific community. However, citation count is susceptible to well-documented variations in citation practices across time and disci…
View article: Noncoding RNAs improve the predictive power of network medicine
Noncoding RNAs improve the predictive power of network medicine Open
Network medicine has improved the mechanistic understanding of disease, offering quantitative insights into disease mechanisms, comorbidities, and novel diagnostic tools and therapeutic treatments. Yet, most network-based approaches rely o…
View article: Network medicine framework reveals generic herb-symptom effectiveness of traditional Chinese medicine
Network medicine framework reveals generic herb-symptom effectiveness of traditional Chinese medicine Open
Understanding natural and traditional medicine can lead to world-changing drug discoveries. Despite the therapeutic effectiveness of individual herbs, traditional Chinese medicine (TCM) lacks a scientific foundation and is often considered…