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View article: 788 Local type 2 stromal-myeloid signalling axis drives progression and immunotherapy resistance of colorectal cancer metastasis
788 Local type 2 stromal-myeloid signalling axis drives progression and immunotherapy resistance of colorectal cancer metastasis Open
View article: 667 Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses
667 Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses Open
View article: Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment
Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment Open
View article: Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms
Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms Open
View article: Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson’s disease
Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson’s disease Open
View article: Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep
Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep Open
Rapid eye movement (REM) sleep is a fundamental sleep state associated with diverse functions from elemental physiological processes to higher order neurocognitive functions. A growing body of research indicates that REM sleep with eye mov…
View article: Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms
Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms Open
SUMMARY "Trained immunity" of innate immune cells occurs through a sequential two-step process where an initial pathogenic or sterile inflammatory trigger is followed by an amplified response to a later un-related secondary pathogen challe…
View article: Setdb2 Regulates Inflammatory Trigger Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms
Setdb2 Regulates Inflammatory Trigger Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms Open
View article: Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer Open
Tertiary lymphoid structures (TLS) are organized immune cell aggregates that arise in chronic inflammatory conditions. In cancer, TLS are associated with better prognosis and enhanced response to immunotherapy, making these structures attr…
View article: Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses
Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses Open
The persistence of adoptively transferred T cells is vital for anti-tumor efficacy. Chimeric antigen receptor (CAR) T cells can persist indefinitely when delivered to patients with B cell cancers and can confer long-term remission. For pat…
View article: 902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis
902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis Open
View article: Sensory-substitution based sound perception using a spinal computer–brain interface
Sensory-substitution based sound perception using a spinal computer–brain interface Open
View article: Predictive modeling of sensory responses in deep brain stimulation
Predictive modeling of sensory responses in deep brain stimulation Open
Introduction Although stimulation-induced sensations are typically considered undesirable side effects in clinical DBS therapy, there are emerging scenarios, such as computer-brain interface applications, where these sensations may be inte…
View article: Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis Open
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematop…
View article: Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture
Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture Open
Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenera…
View article: EGR2 is an epigenomic regulator of phagocytosis and antifungal immunity in alveolar macrophages
EGR2 is an epigenomic regulator of phagocytosis and antifungal immunity in alveolar macrophages Open
Alveolar macrophages (AMs) act as gatekeepers of the lung's immune responses, serving essential roles in recognizing and eliminating pathogens. The transcription factor (TF) early growth response 2 (EGR2) has been recently described as req…
View article: Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors Open
Monocyte–derived macrophages (mo-macs) drive immunosuppression in the tumor microenvironment (TME) and tumor-enhanced myelopoiesis in the bone marrow (BM) fuels these populations. Here, we performed paired transcriptome and chromatin analy…
View article: Epigenomic programming of peripheral monocytes determines their transcriptional response to the tumor microenvironment
Epigenomic programming of peripheral monocytes determines their transcriptional response to the tumor microenvironment Open
Classical monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key det…
View article: The retinoid X receptor has a critical role in synthetic rexinoid-induced increase in cellular all-trans-retinoic acid
The retinoid X receptor has a critical role in synthetic rexinoid-induced increase in cellular all-trans-retinoic acid Open
Rexinoids are agonists of nuclear rexinoid X receptors (RXR) that heterodimerize with other nuclear receptors to regulate gene transcription. A number of selective RXR agonists have been developed for clinical use but their application has…
View article: Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing
Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing Open
Identification of distinct subpopulations of adipose-derived stem cells (ADSCs) in upper body abdominal subcutaneous (ABD) and lower body gluteofemoral subcutaneous (GF) adipose tissue depots. In ABD-ADSCs, subpopulations are more committe…
View article: Ábrándok és remények
Ábrándok és remények Open
Dreams and Hopes. Reflecting on András Gelencsér's book Under the Spell of IllusionsAndrás Gelencsér's study analyses the depletion of the Earth's raw material resources and concludes that it makes the functioning of modern societies unsus…
View article: Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women
Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women Open
Determining the mechanism driving body fat distribution will provide insights into obesity-related health risks. We used functional genomics tools to profile the epigenomic landscape to help infer the differential transcriptional potential…
View article: An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells
An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells Open
The genome of human adipose-derived stem cells (ADSCs) from abdominal and gluteofemoral adipose tissue depots are maintained in depot-specific stable epigenetic conformations that influence cell-autonomous gene expression patterns and driv…
View article: The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages
The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages Open
Introduction Macrophages significantly contribute to the regulation of vessel formation under physiological and pathological conditions. Although the angiogenesis-regulating role of alternatively polarized macrophages is quite controversia…
View article: Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation
Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation Open
Macrophage polarization is a process whereby macrophages develop a specific phenotype and functional response to different pathophysiological stimuli and tissue environments. In general, two main macrophage phenotypes have been identified:…
View article: Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics
Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics Open
Retinoid X receptors (RXRs) are nuclear transcription factors that partner with other nuclear receptors to regulate numerous physiological processes. Although RXR represents a valid therapeutic target, only a few RXR-specific ligands (rexi…
View article: The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands
The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands Open
View article: Clinical parameters predict the effect of bilateral subthalamic stimulation on dynamic balance parameters during gait in Parkinson's disease
Clinical parameters predict the effect of bilateral subthalamic stimulation on dynamic balance parameters during gait in Parkinson's disease Open
We investigated the effect of deep brain stimulation on dynamic balance during gait in Parkinson's disease with motion sensor measurements and predicted their values from disease-related factors. We recruited twenty patients with Parkinson…
View article: Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells
Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells Open
Accumulation of fat above the waist is an important risk factor in developing obesity-related comorbidities independently of BMI or total fat mass. Deciphering the gene regulatory programs of the adipose tissue precursor cells within upper…
View article: Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson’s disease: A cross-sectional study
Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson’s disease: A cross-sectional study Open
Background Balance impairment in Parkinson’s disease is multifactorial and its changes due to subthalamic stimulation vary in different studies. Objective We aimed to analyze the combination of predictive clinical factors of balance impair…