László Muszbek
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View article: Protective Effect of Factor XIII Intron-K G Allele on Subclinical Vascular Disease
Protective Effect of Factor XIII Intron-K G Allele on Subclinical Vascular Disease Open
Carotid artery intima–media thickness (cIMT), a pre-clinical vascular change that accompanies atherosclerosis is considered as a cardiovascular risk factor. Coagulation factor XIII (FXIII) stabilizes the fibrin clot and increases its resis…
View article: Cellular FXIII in Human Macrophage-Derived Foam Cells
Cellular FXIII in Human Macrophage-Derived Foam Cells Open
Macrophages express the A subunit of coagulation factor XIII (FXIII-A), a transglutaminase which cross-links proteins through Nε-(γ-L-glutamyl)-L-lysyl iso-peptide bonds. Macrophages are major cellular constituents of the atherosclerotic p…
View article: Cellular FXIII in Human Macrophage Derived Foam Cells
Cellular FXIII in Human Macrophage Derived Foam Cells Open
The potentially active A subunit of coagulation factor XIII (FXIII-A) is an intracellular transglutaminase expressed in various cell types including platelets and monocytes/macrophages. It is involved in stabilizing protein structures by c…
View article: Cellular FXIII in Human Macrophage Derived Foam Cells
Cellular FXIII in Human Macrophage Derived Foam Cells Open
The potentially active A subunit of coagulation factor XIII (FXIII-A) is an intracellular transglutaminase expressed in various cell types including platelets and monocytes/macrophages. It is involved in stabilizing protein structures by c…
View article: The Effect of Activated FXIII, a Transglutaminase, on Vascular Smooth Muscle Cells
The Effect of Activated FXIII, a Transglutaminase, on Vascular Smooth Muscle Cells Open
Plasma factor XIII (pFXIII) is a heterotetramer of FXIII-A and FXIII-B subunits. The cellular form (cFXIII), a dimer of FXIII-A, is present in a number of cell types. Activated FXIII (FXIIIa), a transglutaminase, plays an important role in…
View article: Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles Open
The elevation of intracellular Ca2+ concentration is sufficient for the translocation of PS from the internal layer of the membrane, while the translocation of cFXIII from the platelet cytoplasm requires additional receptor mediated mechan…
View article: Terminal Phase Components of the Clotting Cascade in Patients with End-Stage Renal Disease Undergoing Hemodiafiltration or Hemodialysis Treatment
Terminal Phase Components of the Clotting Cascade in Patients with End-Stage Renal Disease Undergoing Hemodiafiltration or Hemodialysis Treatment Open
Hemostasis disorder in patients with end-stage renal disease (ESRD) is frequently associated with bleeding diathesis but it may also manifest in thrombotic complications. Analysis of individual coagulation and fibrinolytic factors may shed…
View article: Autoimmune factor XIII deficiency with unusual laboratory and clinical phenotype
Autoimmune factor XIII deficiency with unusual laboratory and clinical phenotype Open
Hemorrhagic diathesis due to anti-factor XIII (FXIII) autoantibody is a rare but severe disorder. Challenges of the diagnosis and treatment is demonstrated by the case of a 67-year-old female without previous bleeding history, who suffered…
View article: N‐glycosylation of blood coagulation factor XIII subunit B and its functional consequence
N‐glycosylation of blood coagulation factor XIII subunit B and its functional consequence Open
Characterization of the glycan moieties attached to FXIII-B is reported for the first time. Complete deglycosylation of the native protein was achieved by a deglycosylation workflow. The associated glycan structure is not required for FXII…
View article: Cellular Factor XIII, a Transglutaminase in Human Corneal Keratocytes
Cellular Factor XIII, a Transglutaminase in Human Corneal Keratocytes Open
Cellular factor XIII (cFXIII, FXIII-A2), a transglutaminase, has been demonstrated in a few cell types. Its main function is to cross-link proteins by isopeptide bonds. Here, we investigated the presence of cFXIII in cells of human cornea.…
View article: A new ELISA method for the measurement of total α2-plasmin inhibitor level in human body fluids
A new ELISA method for the measurement of total α2-plasmin inhibitor level in human body fluids Open
The ever-increasing research efforts to develop new antithrombotic therapies have led to the reassessment of the role of alpha-2-plasmin inhibitor (α2-PI) in pathological conditions. In particular, experimental stroke studies have suggeste…
View article: Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients
Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients Open
Factor XIII (FXIII) stabilizes and protects the fibrin network. Its role in myocardial infarction (MI) is still to be clarified. To evaluate the association of FXIII levels with MI in young patients and to investigate how the FXIII-A p.Val…
View article: Clinical and laboratory characteristics of antithrombin deficiencies: A large cohort study from a single diagnostic center
Clinical and laboratory characteristics of antithrombin deficiencies: A large cohort study from a single diagnostic center Open
Type IIHBS deficiencies behave differently in clinical and laboratory phenotypes from each other and from other AT deficiencies. Heparin concentration and pH seem to be the key factors influencing the sensitivity of AT functional assays to…
View article: Antithrombin Debrecen (p.Leu205Pro) – Clinical and molecular characterization of a novel mutation associated with severe thrombotic tendency
Antithrombin Debrecen (p.Leu205Pro) – Clinical and molecular characterization of a novel mutation associated with severe thrombotic tendency Open
AT Debrecen was associated with very severe thrombotic tendency. The mutation led to misfolded AT, impaired secretion and altered function. Detailed clinical and molecular characterization of a pathogenic mutation might provide valuable in…
View article: Minimal factor XIII activity level to prevent major spontaneous bleeds
Minimal factor XIII activity level to prevent major spontaneous bleeds Open
Background Congenital factor XIII (FXIII) deficiency is a rare bleeding disorder associated with significant bleeding manifestations. The European Network of Rare Bleeding Disorders (EN-RBD) study, performed from 2007 to 2010, showed a str…
View article: Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation
Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation Open
Aims . To identify intracardiac hemostasis or fibrinolysis abnormalities, which are associated with atrial fibrillation (AF) and increase the risk of thromboembolism. Patients and Methods . Patient group consisted of 24 patients with AF an…
View article: 136-06: Haemostasis changes during percutaneous transcatheter isolation of the pulmonary veins in patients with atrial fibrillation
136-06: Haemostasis changes during percutaneous transcatheter isolation of the pulmonary veins in patients with atrial fibrillation Open
Introduction: Silent or manifest cerebral thromboembolisation is a potential complication of left atrial (LA) ablation (ABL) for atrial fibrillation (AF). The influence of different ablation techniques on different haemostasis parameters h…
View article: Neutralizing autoantibody against factor XIII A subunit resulted in severe bleeding diathesis with a fatal outcome – characterization of the antibody
Neutralizing autoantibody against factor XIII A subunit resulted in severe bleeding diathesis with a fatal outcome – characterization of the antibody Open
Autoantibodies may develop against the catalytic A subunit of factor XIII (FXIII-A) or the carrier B subunit (FXIII-B). Autoimmune FXIII-A deficiency was diagnosed in an elderly (75 years) patient with severe bleeding symptoms. The patient…
View article: The lack of aspirin resistance in patients with coronary artery disease
The lack of aspirin resistance in patients with coronary artery disease Open
No aspirin resistance was detected among patients with stable coronary artery disease. COX2 expression in platelets did not influence the effect of aspirin.
View article: Evaluation of flow cytometric <scp>HIT</scp> assays in relation to an <scp>I</scp>g<scp>G</scp>‐Specific immunoassay and clinical outcome
Evaluation of flow cytometric <span>HIT</span> assays in relation to an <span>I</span>g<span>G</span>‐Specific immunoassay and clinical outcome Open
Background Heparin‐induced thrombocytopenia (HIT) is a severe side effect of heparin treatment caused by platelet activating IgG antibodies generated against the platelet factor 4 (PF4)–heparin complex. Thrombocytopenia and thrombosis are …