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View article: Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice
Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice Open
Background: Cognitive, emotional, and social impairments are pervasive across neuropsychiatric conditions, where alterations in the tryptophan (Trp)–kynurenine pathway and its product kynurenic acid (KYNA) from kynurenine aminotransferases…
View article: Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice
Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice Open
Background: Cognitive, emotional, and social impairments are pervasive across neuropsychiatric conditions, where alterations in the tryptophan (Trp)–kynurenine pathway and its product kynurenic acid (KYNA) from kynurenine aminotransferases…
View article: Kynurenic Acid Protects Against Myocardial Ischemia/Reperfusion Injury by Activating GPR35 Receptors and Preserving Mitochondrial Structure and Function
Kynurenic Acid Protects Against Myocardial Ischemia/Reperfusion Injury by Activating GPR35 Receptors and Preserving Mitochondrial Structure and Function Open
Acute myocardial infarction, often associated with ischemia/reperfusion injury (I/R), is a major healthcare issue ranking among the leading causes of death globally. Although kynurenic acid (KYNA), an endogenous tryptophan metabolite, has …
View article: Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice
Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice Open
Background: Cognitive, emotional, and social dysfunctions pervade neuropsychiatric disorders; dysregulated tryptophan (Trp)–kynurenine signaling, notably kynurenic acid (KYNA) from kynurenine aminotransferases (KATs), is implicated in Alzh…
View article: Real-World Laboratory Analysis of Molecular Biomarkers in Multiple Sclerosis Centers in Central-Eastern European Countries Covering 107 Million Inhabitants
Real-World Laboratory Analysis of Molecular Biomarkers in Multiple Sclerosis Centers in Central-Eastern European Countries Covering 107 Million Inhabitants Open
A multicenter molecular biomarker survey was conducted in Multiple Sclerosis (MS) centers across Central-Eastern European countries, encompassing a population of 107 million. Our aim was to provide a “snapshot” for future studies investiga…
View article: From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit Open
The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial omics, wearable chronobiology, and synthetic microbiota studies reve…
View article: From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit Open
The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial-omics, wearable chronobiology, and synthetic-microbiota studies reve…
View article: Real-World Laboratory Analysis of Molecular Biomarkers in Multiple Sclerosis Centers in Central-Eastern European Coun-tries Covering 107 Million Inhabitants
Real-World Laboratory Analysis of Molecular Biomarkers in Multiple Sclerosis Centers in Central-Eastern European Coun-tries Covering 107 Million Inhabitants Open
A multicenter molecular biomarker survey was conducted in Multiple Sclerosis (MS) cen-ters across Central-Eastern European countries, encompassing a population of 107 mil-lion. Our aim was to provide a "snapshot" for future studi…
View article: Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression
Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression Open
Higher serum ALA levels were associated with a lower risk of CDMS, relapses, and disability progression in a large prospective cohort. The results were null or inconsistent for other fatty acids.
View article: Decoupling Behavioral Domains via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics
Decoupling Behavioral Domains via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics Open
Kynurenic acid (KYNA), a putative neuroprotective agent, modulates glutamatergic pathways in schizophrenia and Parkinson’s disease but is limited by acute motor activity impairments (e.g., ataxia). Research leveraging animal disease models…
View article: From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit Open
The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial-omics, wearable chronobiology, and synthetic-microbiota studies reve…
View article: Új perspektívák a migrén kezelésében: a kinureninrendszer szerepe a migrén patofiziológiájában
Új perspektívák a migrén kezelésében: a kinureninrendszer szerepe a migrén patofiziológiájában Open
A migrén a primer fejfájások egyik leggyakoribb formája. A betegség az érintettek életminőségének csökkenése mellett komoly gazdasági problémákat okoz világszerte a munkából való kiesés miatt. A migrén pontos patofiziológiája nem ismert, í…
View article: Kynurenines and Mitochondrial Disturbances in Multiple Sclerosis
Kynurenines and Mitochondrial Disturbances in Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic autoimmune disease characterised by inflammation, demyelination, and neurodegeneration within the central nervous system. The pathogenesis of MS involves an immune-mediated attack on myelin and neurons,…
View article: Decoupling Neuroprotection and Motor Dysfunction via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics
Decoupling Neuroprotection and Motor Dysfunction via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics Open
Kynurenic acid (KYNA), a putative neuroprotective agent, modulates glutamatergic pathways in Schizophrenia and Parkinson’s Disease but is limited by acute motor activity impairments (e.g., ataxia). Research leveraging animal disease models…
View article: The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration
The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration Open
Numerous illnesses, including neurological and mental disorders, have been associated with mitochondrial dysfunction. Disruptions in mitochondrial respiration and energy production have been linked to dysmetabolism of the tryptophan (Trp)‐…
View article: Long-Term Cuprizone Administration Resulted in Cognitive Decline and Kynurenine Metabolic Disturbance
Long-Term Cuprizone Administration Resulted in Cognitive Decline and Kynurenine Metabolic Disturbance Open
The cuprizone (CPZ) toxin-induce animal model is suitable for studying the neurodegenerative processes of multiple sclerosis (MS) and the underlying molecular mechanisms. Cognitive de-cline is widespread in MS and has a marked impact on th…
View article: Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design
Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design Open
Background: Quinoline-derived metabolites exhibit notable chemical complexity. What causes minor structural alterations to induce significant changes in disease outcomes? Historically, eclipsed by more straightforward scaffolds, these chem…
View article: Decoupling Neuroprotection and Motor Dysfunction via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics
Decoupling Neuroprotection and Motor Dysfunction via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics Open
Kynurenic acid (KYNA), a putative neuroprotective agent, modulates glutamatergic pathways in Schizophrenia and Parkinson’s Disease but is limited by acute motor activity impairments (e.g., ataxia). Research leveraging animal disease models…
View article: Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design
Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design Open
Background: Quinoline-derived metabolites exhibit notable chemical complexity. What causes minor structural alterations to induce significant changes in disease outcomes? Historically eclipsed by more straightforward scaffolds, these chemi…
View article: Distinct expression of NEAT1 isoforms in Parkinson’s disease models suggests different roles of the variants during the disease course
Distinct expression of NEAT1 isoforms in Parkinson’s disease models suggests different roles of the variants during the disease course Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Recently long non-coding RNAs (lncRNAs) have emerged as possible molecular hubs in the diverse pathomechanisms of the disease. Among them, NEAT1 gained…
View article: Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design
Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design Open
Background: Quinoline-derived metabolites exhibit notable chemical complexity. What causes minor structural alterations to induce significant changes in disease outcomes? Historically eclipsed by more straightforward scaffolds, these chemi…
View article: Age-dependent changes in NMDA-induced excitotoxicity and neuromodulatory effects of kynurenic acid and its analogue in mouse brain slices
Age-dependent changes in NMDA-induced excitotoxicity and neuromodulatory effects of kynurenic acid and its analogue in mouse brain slices Open
View article: Pillanatok a 65 éves Szegedi Akadémiai Bizottság történetéből
Pillanatok a 65 éves Szegedi Akadémiai Bizottság történetéből Open
A Magyar Tudományos Akadémia, a területi akadémiai bizottságok sorában elsőként hozta létre a Szegedi Akadémiai Bizottságot azzal a céllal, hogy Szeged és a környező vidék akadémiai tagjainak, tudósainak munkáját támogassa, a tudományosság…
View article: Correction: Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction
Correction: Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction Open
View article: Thrombolysis in lacunar stroke: Comparison of early neurological improvement and 90-day functional outcome with cardioembolic stroke without large-vessel occlusion
Thrombolysis in lacunar stroke: Comparison of early neurological improvement and 90-day functional outcome with cardioembolic stroke without large-vessel occlusion Open
View article: The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals
The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals Open
View article: Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model
Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model Open
The cuprizone (CPZ) model of multiple sclerosis (MS) is excellent for studying the molecular differences behind the damage caused by poisoning. Metabolic differences in the kynurenine pathway (KP) of tryptophan (TRP) degradation are observ…
View article: CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide
CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide Open
Migraines are a frequently occurring neurological condition that affects up to 16% of the global population. The precise pathomechanism of the disease remains unknown, but from animal and human observations, it appears that calcium/calmodu…
View article: Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder
Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder Open
Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked to disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp…
View article: Correction to: Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction
Correction to: Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction Open