Latifa Doudach
YOU?
Author Swipe
View article: Machine learning prediction of histological types of breast cancer: a case study in Morocco
Machine learning prediction of histological types of breast cancer: a case study in Morocco Open
View article: Phytochemical, Antidiabetic, Antioxidant, Antibacterial, Acute and Sub-Chronic Toxicity of Moroccan <i>Arbutus unedo</i> Leaves
Phytochemical, Antidiabetic, Antioxidant, Antibacterial, Acute and Sub-Chronic Toxicity of Moroccan <i>Arbutus unedo</i> Leaves Open
The study highlighted several biological advantages of A. unedo leaves without toxic effects in short-term application. Our findings suggest that conducting more comprehensive and extensive in vivo investigations is of utmost…
View article: Mineral contents, antimicrobial profile, acute and chronic toxicity of the aqueous extract of Moroccan Thymus vulgaris in rodents
Mineral contents, antimicrobial profile, acute and chronic toxicity of the aqueous extract of Moroccan Thymus vulgaris in rodents Open
Moroccan flora is rich in plants used in traditional medicine, but the further scientific investigation is necessary. The aim of the research was to evaluate the nutritional content and antimicrobial activity of Moroccan Thymus vulgaris, a…
View article: In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics Open
Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern. Multiple drug resistance has also …
View article: Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines
Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines Open
Despite the decades of scientific studies for developing promising new therapies, cancer remains a major cause of illness and mortality, worldwide. Several cancer types are the major topic of research in drug discovery programs due to thei…
View article: Profile of Medicinal Plants Traditionally Used for the Treatment of Skin Burns
Profile of Medicinal Plants Traditionally Used for the Treatment of Skin Burns Open
Moroccan folk healers use medicinal plants to treat several diseases including skin burns. The traditional knowledge of wound healing is not common among the general population. Only one ethnobotanical survey was carried out in Rabat, Moro…
View article: Antibacterial Evaluation of The Roots of Moroccan Aristolochia longa Against Referenced Gram-positive and Gram-negative Bacteria
Antibacterial Evaluation of The Roots of Moroccan Aristolochia longa Against Referenced Gram-positive and Gram-negative Bacteria Open
Background: Interest in medicinal plants has recently risen as a consequence of its therapeutic capabilities, which require further investigation. Aristolochia longa (A. longa) roots are commonly employed in traditional Moroccan medicine a…
View article: Acute toxicity, phenol content, antioxidant and postprandial anti-diabetic activity of Echinops spinosus extracts
Acute toxicity, phenol content, antioxidant and postprandial anti-diabetic activity of Echinops spinosus extracts Open
Echinops spinosus, belonging to Asteraceae family, is used in folk medicine as an abortifacient and diuretic and for blood circulation, diabetes, stomach pain, indigestion and spasmolytic problems. The objective of this work is the study o…
View article: Molecular Docking and QSAR Studies for Modeling the Inhibitory Activity of Pyrazole-benzimidazolone Hybrids as Novel Inhibitors of Human 4-hydroxyphenylpyruvate dioxygenase Against Type I Tyrosinemia Disease
Molecular Docking and QSAR Studies for Modeling the Inhibitory Activity of Pyrazole-benzimidazolone Hybrids as Novel Inhibitors of Human 4-hydroxyphenylpyruvate dioxygenase Against Type I Tyrosinemia Disease Open
Pyrazole-benzimidazolone is a novel inhibitor of human 4-Hydroxyphenylpyruvate dioxygenase of the HPPD receptor. To analyze this inhibitory activity, a QSAR study was performed using 33 compounds. The MLR multiple linear regression method …
View article: Mineral and Phenolic Composition of <i>Erodium guttatum</i> Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice
Mineral and Phenolic Composition of <i>Erodium guttatum</i> Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice Open
Erodium guttatum is widely used in folk medicine in many countries to treat various ailments such as urinary inflammation, diabetes, constipation, and eczema. The aim of this study is the determination of mineral and phenolic compounds of …
View article: Phytochemistry and Pharmacology of Thymus broussonetii Boiss
Phytochemistry and Pharmacology of Thymus broussonetii Boiss Open
Thymus broussonetii Boiss (T. broussonetii) is a rare medicinal and aromatic plant. It is widely used in traditional medicine to treat several diseases, including diarrhea, fever, cough, irritation, skin diseases, rheumatism, respiratory a…
View article: Phenolic content, antibacterial, antioxidant, and toxicological investigations of Erodium guttatum (Geraniaceae) collected from the Northeast of Morocco
Phenolic content, antibacterial, antioxidant, and toxicological investigations of Erodium guttatum (Geraniaceae) collected from the Northeast of Morocco Open
Erodium genus contains several medicinal traditionally used and pharmacologically explored. However, Erodium guttatum has not been well valorized. Therefore, the aim of the present study was to evaluate the antibacterial and antioxidant ac…
View article: Hepatoprotective Effect of Corrigiola telephiifolia Pourr. Root Methanolic Extracts against CCl4-Induced Hepatic Damage in Mice
Hepatoprotective Effect of Corrigiola telephiifolia Pourr. Root Methanolic Extracts against CCl4-Induced Hepatic Damage in Mice Open
Liver disease is a dysfunction that affects all or part of the liver and can lead to death. While the use of medicinal and aromatic plants has been a source of bioactive substances with hepatoprotective properties. This study aims to evalu…
View article: Ethnobotanical Survey of Medicinal Plants Used by Traditional Healers to Treat Diabetes in the Taza Region of Morocco
Ethnobotanical Survey of Medicinal Plants Used by Traditional Healers to Treat Diabetes in the Taza Region of Morocco Open
Type 2 diabetes is one of the noncommunicable diseases that is becoming a pandemic in Africa. In Morocco, traditional healers have started to use herbal medicines for the treatment of diabetes either individually or in combination with foo…
View article: Equilibrium Dialysis and Ultrafiltration Compared for Determining the Protein Binding Rates of 99mTc-DTPA
Equilibrium Dialysis and Ultrafiltration Compared for Determining the Protein Binding Rates of 99mTc-DTPA Open
Diethylene triaminopentaacetic acid ( 99m Tc-DTPA) is one of the technetium radiopharmaceuticals mostly used in renal imaging for evaluation of glomera filtration rate. The 99m Tc-DTPA binding rates on plasma proteins was investigated usi…