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View article: <sup>129</sup> Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy
<sup>129</sup> Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy Open
Rationale Airways dysanapsis is defined by CT or spirometry as a mismatch between the size of the airways and lung volume and is associated with increased risk of developing chronic obstructive pulmonary disease (COPD). Lung disease in par…
View article: P176 Bronchodilator response discordance in patients with asthma and/or COPD assessed by 129Xe-MRI and spirometry
P176 Bronchodilator response discordance in patients with asthma and/or COPD assessed by 129Xe-MRI and spirometry Open
Introduction 129Xe-MRI directly images the distribution of ventilation in the lung making it ideal for assessing bronchodilator response (BDR). Here we compared the concordance of BDR using 129Xe-MRI and FEV1 and also assessed if the magni…
View article: P177 129Xe MRI phenotyping and longitudinal change in patients with asthma and/or COPD and normal pulmonary function tests
P177 129Xe MRI phenotyping and longitudinal change in patients with asthma and/or COPD and normal pulmonary function tests Open
Introduction 129Xe-MRI provides sensitive measures of pulmonary function and microstructure and may be useful in phenotyping patients and monitoring disease progression. Methods Patients with asthma and/or COPD from NOVELTY [NCT02760329] w…
View article: Functional imaging in asthma and COPD: design of the NOVELTY ADPro substudy
Functional imaging in asthma and COPD: design of the NOVELTY ADPro substudy Open
The NOVEL observational longiTudinal studY (NOVELTY; ClinicalTrials.gov identifier NCT02760329 ) is a global, prospective, observational study of ∼12 000 patients with a diagnosis of asthma and/or COPD. Here, we describe the design of the …