Laura A. Jacobs
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View article: The Role of β-Dystroglycan in Nuclear Dynamics
The Role of β-Dystroglycan in Nuclear Dynamics Open
Dystroglycan is a ubiquitously expressed heterodimeric cell-surface laminin receptor with roles in cell adhesion, signalling, and membrane stabilisation. More recently, the transmembrane β-subunit of dystroglycan has been shown to localise…
View article: Standards of Care for the Health of Transgender and Gender Diverse People, Version 8
Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 Open
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View article: Technical challenges of working with extracellular vesicles
Technical challenges of working with extracellular vesicles Open
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions.
View article: Functional imaging in combination with mutation status aids prediction of response to inhibiting B-cell receptor signaling in lymphoma
Functional imaging in combination with mutation status aids prediction of response to inhibiting B-cell receptor signaling in lymphoma Open
Aberrant B-cell receptor (BCR) signaling is known to contribute to malignant transformation. Two small molecule inhibitors targeting BCR pathway signaling include ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, and idelalisib, a spe…
View article: Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus
Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus Open
β-Dystroglycan (β-DG) is a transmembrane protein with critical roles in cell adhesion, cytoskeleton remodeling and nuclear architecture. This functional diversity is attributed to the ability of β-DG to target to, and conform specific prot…
View article: Extracellular vesicles released following heat stress induce bystander effect in unstressed populations
Extracellular vesicles released following heat stress induce bystander effect in unstressed populations Open
Cells naïve to stress can display the effects of stress, such as DNA damage and apoptosis, when they are exposed to signals from stressed cells; this phenomenon is known as the bystander effect. We previously showed that bystander effect i…
View article: HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling
HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling Open
Key Points HSP90 inhibition induces apoptosis in BL cells by disrupting tonic BCR signaling. SYK is an HSP90 client protein, and BCR signaling-dependent phosphorylation of HSP90 on Y197 is required for this interaction.
View article: Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia
Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia Open
Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. CXCR4/CXCL12 interaction is crucially involved in recruitment and retention of leukemia-initiating cells within this niche. V…