Laura Bear
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View article: The contribution of a short electrocardiographic diastolic interval to diastolic dysfunction and HFpEF
The contribution of a short electrocardiographic diastolic interval to diastolic dysfunction and HFpEF Open
Not applicable.
View article: ECG electrode localization using 3D visual reconstruction
ECG electrode localization using 3D visual reconstruction Open
Body surface potential maps (BSPMs) derived from multi-channel ECG recordings enable the detection and diagnosis of electrophysiological phenomena beyond the standard 12-lead ECG. In this work, we developed two AI-based methods for the aut…
View article: Influence of pericardium on ventricular mechanical interdependence in an isolated biventricular working pig heart model
Influence of pericardium on ventricular mechanical interdependence in an isolated biventricular working pig heart model Open
The pericardium plays an important role in mechanical interactions between the right (RV) and left (LV) ventricles, referred to as ventricular interdependence. However, the exact mechanisms of its supportive role remain unknown. The presen…
View article: Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity
Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity Open
This model of localized repolarization heterogeneity is able to produce spontaneous VF initiation. Our study demonstrates that VF triggers originate consistently from the border zone of repolarization dispersion.
View article: Evaluation of five methods for the interpolation of bad leads in the solution of the inverse electrocardiography problem
Evaluation of five methods for the interpolation of bad leads in the solution of the inverse electrocardiography problem Open
Objective. This study aims to assess the sensitivity of epicardial potential-based electrocardiographic imaging (ECGI) to the removal or interpolation of bad leads. Approach. We utilized experimental data from two distinct centers. Langend…
View article: A His bundle pacing protocol for suppressing ventricular arrhythmia maintenance and improving defibrillation efficacy
A His bundle pacing protocol for suppressing ventricular arrhythmia maintenance and improving defibrillation efficacy Open
HBP can reduce the amount of excitable gap and suppress reentry maintenance in the HPN and myocardium. HBP can also improve the efficacy of low-energy defibrillation approaches targeting excitable myocardium. HBP during reentrant arrhythmi…
View article: Adaptive placement of the pseudo-boundaries improves the conditioning of the inverse problem
Adaptive placement of the pseudo-boundaries improves the conditioning of the inverse problem Open
Meshing the heart and measurement surfaces can be time consuming, especially when dealing with complicated geometries or cardiac motion. To overcome this, a meshless method based on the method of fundamental solutions (MFS) has been adapte…
View article: Evaluation of fifteen algorithms for the resolution of the electrocardiography imaging inverse problem using ex-vivo and in-silico data
Evaluation of fifteen algorithms for the resolution of the electrocardiography imaging inverse problem using ex-vivo and in-silico data Open
The electrocardiographic imaging inverse problem is ill-posed. Regularization has to be applied to stabilize the problem and solve for a realistic solution. Here, we assess different regularization methods for solving the inverse problem. …
View article: Effect of the torso conductivity heterogeneities on the ECGI inverse problem solution
Effect of the torso conductivity heterogeneities on the ECGI inverse problem solution Open
The effect of torso conductivity heterogeneities on the electrocardiographic imaging (ECGI) inverse problem solution is still subject of debate. In this study we present a method to assess the effect of these heterogeneities. We use an ana…
View article: New Mathematical approaches in Electrocardiography Imaging inverse problem
New Mathematical approaches in Electrocardiography Imaging inverse problem Open
Improve ECGI inverse problem reconstruction Introduce new mathematical approches to the field of the ECGI inverse problem Compare the performance of the new mathematical approaches to the state-of-the-art methods, mainly the MFS method use…
View article: Local Conduction Velocity Mapping for Electrocardiographic Imaging
Local Conduction Velocity Mapping for Electrocardiographic Imaging Open
Slow conduction is a well-known pro-arrhythmic feature for tachycardia and fibrillation. Cardiac conduction velocity (CV) mapping can be extremely helpful for investigating unusual activation patterns. Although methods have been developed …
View article: Accuracy of Lead Removal vs Linear Interpolation in Non-Invasive Electrocardiographic Imaging (ECGI)
Accuracy of Lead Removal vs Linear Interpolation in Non-Invasive Electrocardiographic Imaging (ECGI) Open
This study examines the effect of missing body surface potentials on inverse solutions, and determines if linear interpolation can regain information lost. Using simulated and experimental data, electrograms (EGMs) were reconstructed after…
View article: A Patchwork Method to improve the performance of the current ECGI methods for sinus rythm
A Patchwork Method to improve the performance of the current ECGI methods for sinus rythm Open
Noninvasive electrocardiographic imaging (ECGI) pro-vides real-time panoramic images of epicardial electri-cal activity from potential measurements on the torso surface. This non-invasive imaging modality can be-come a powerful clinical to…
View article: Do we need to enforce the homogeneous Neumann condition on the torso for solving the inverse electrocardiographic problem?
Do we need to enforce the homogeneous Neumann condition on the torso for solving the inverse electrocardiographic problem? Open
Robust calculations of the inverse electrocardiographicproblem may require accurate specification of boundaryconditions at the torso and cardiac surfaces. In particular,the numerical specification of the no-flux condition onthe torso is di…
View article: A shortened electrocardiographic diastolic interval is involved in diastolic dysfunction and HFpEF
A shortened electrocardiographic diastolic interval is involved in diastolic dysfunction and HFpEF Open
Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by left ventricular diastolic dysfunction (LVDD). We hypothesized that a short electrocardiographic diastolic time predisposes to LVDD a…
View article: Investigation into the importance of using natural PVCs and pathological models for potential-based ECGI validation
Investigation into the importance of using natural PVCs and pathological models for potential-based ECGI validation Open
Introduction: Premature ventricular contractions (PVCs) are one of the most commonly targeted pathologies for ECGI validation, often through ventricular stimulation to mimic the ectopic beat. However, it remains unclear if such stimulated …
View article: The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest
The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest Open
Sudden cardiac death is often caused by ventricular arrhythmias driven by reentry. Comprehensive characterization of the potential triggers and substrate in survivors of sudden cardiac arrest has provided insights into the trigger-substrat…
View article: Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited
Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited Open
Background: The optimal way to determine repolarization time (RT) from the intracardiac unipolar electrogram (UEG) has been a topic of debate for decades. RT is typically determined by either the Wyatt method or the “alternative method,” w…
View article: A novel framework for the removal of pacing artifacts from bio-electrical recordings
A novel framework for the removal of pacing artifacts from bio-electrical recordings Open
A novel signal processing framework enabled efficient analysis of bio-electrical recordings with stimulation artifacts. This will allow the bio-electrical events induced by stimulation protocols to be efficiently and systematically evaluat…
View article: Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T‐wave parameters
Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T‐wave parameters Open
Background The T wave of the electrocardiogram (ECG) reflects ventricular repolarization. Repolarization heterogeneity is associated with reentrant arrhythmias. Several T‐wave markers (including QT interval) have been associated with ventr…
View article: Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers
Non-Contact Intracardiac Potential Mapping Using Mesh-Based and Meshless Inverse Solvers Open
Atrial fibrillation (AF) is the most common cardiac dysrhythmia and percutaneous catheter ablation is widely used to treat it. Panoramic mapping with multi-electrode catheters has been used to identify ablation targets in persistent AF but…
View article: A Patchwork Method to Improve the Performance of Current Methods for Solving the Inverse Problem of Electrocardiography
A Patchwork Method to Improve the Performance of Current Methods for Solving the Inverse Problem of Electrocardiography Open
This novel method for optimizing ECGI solutions opens a new avenue for improving not only ECGI but also other inverse problems.
View article: Intracardiac Inverse Potential Mapping Using the Method of Fundamental Solutions
Intracardiac Inverse Potential Mapping Using the Method of Fundamental Solutions Open
Introduction: Atrial fibrillation (AF) is the most prevalent cardiac dysrhythmia and percutaneous catheter ablation is widely used to treat it. Panoramic mapping with multi-electrode catheters can identify ablation targets in persistent AF…
View article: Solving Inverse Electrocardiographic Mapping Using Machine Learning and Deep Learning Frameworks
Solving Inverse Electrocardiographic Mapping Using Machine Learning and Deep Learning Frameworks Open
Electrocardiographic imaging (ECGi) reconstructs electrograms at the heart’s surface using the potentials recorded at the body’s surface. This is called the inverse problem of electrocardiography. This study aimed to improve on the current…
View article: Spatiotemporal approximation of cardiac activation and recovery isochrones
Spatiotemporal approximation of cardiac activation and recovery isochrones Open
The spatiotemporal method to compute activation and recovery times from EGMs outperformed the traditional temporal-only approach in which spatial information was not taken into account.
View article: Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation
Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation Open
Aims Mapping data of human ventricular fibrillation (VF) are limited. We performed detailed mapping of the activities underlying the onset of VF and targeted ablation in patients with structural cardiac abnormalities. Methods and results W…
View article: Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation
Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation Open
Premature beats originating in clinically concealed areas of local early repolarization promote ventricular arrhythmias and sudden cardiac arrest.
View article: A Patchwork Inverse Method in Combination with the Activation Time Gradient to Detect Regions of Slow Conduction in Sinus Rhythm
A Patchwork Inverse Method in Combination with the Activation Time Gradient to Detect Regions of Slow Conduction in Sinus Rhythm Open
Background: Noninvasive electrocardiographic imaging (ECGI) provides real-time panoramic images of epicardial electrical activity from potential measurements on the torso surface. Several numerical methods are commonly used for ECGI, inclu…