Laura Bevan
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Aged Zebrafish as a Spontaneous Model of Cardiac Valvular Disease Open
Valvular heart disease (VHD) is a highly prevalent age‐associated cardiovascular pathology. VHD can be characterised by stenosis, an increase in valve stiffening commonly due to leaflet calcification, or regurgitation, where backflow of bl…
Absence of a prolonged macrophage and B cell response inhibits heart regeneration in <i>the Mexican cavefish</i> Open
A balanced immune response after cardiac injury is crucial to successful heart regeneration, but knowledge of what distinguishes a regenerative from a scarring response is still limited. The Mexican cavefish provides a unique comparative m…
Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart Open
Mononuclear phagocytes (MNPs) are recognised as highly plastic, multifunctional cells that influence multiple physiological and pathophysiological states. In the heart, they support homeostatic functions, contribute to disease progression …
Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart Open
Mononuclear phagocytes (MNPs) are recognised as highly plastic, multifunctional cells that influence multiple physiological and pathophysiological states. In the heart, they support homeostatic functions, contribute to disease progression …
Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart Open
Mononuclear phagocytes (MNPs) are recognised as highly plastic, multifunctional cells that influence multiple physiological and pathophysiological states. In the heart, they support homeostatic functions, contribute to disease progression …
Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish Open
Aims A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not o…
Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice Open
Absence of Th1 lymphocytes is associated with reduced plaque size in ApoE knockout mice fed a normal but not high fat diet. In either case, M1 macrophage polarization and expression of several MMPs related to plaque instability are either …