Laura Sutton
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View article: The PRAMS (Perinatal Redesign for Accessing Mental Health Services) Study: a research protocol
The PRAMS (Perinatal Redesign for Accessing Mental Health Services) Study: a research protocol Open
Background Perinatal mental health (PMH) problems affect 10-20% of women during pregnancy and the postnatal year, costing the UK an estimated £8.1 billion annually. Underserved groups—including women from ethnic minorities, deprived areas,…
View article: Multiple Symptoms Study 3 – An extended-role general practitioner clinic for patients with persistent physical symptoms: a Randomised Controlled Trial
Multiple Symptoms Study 3 – An extended-role general practitioner clinic for patients with persistent physical symptoms: a Randomised Controlled Trial Open
Background People with multiple and persistent physical symptoms have impaired quality of life and poor experiences of health care. We aimed to evaluate the effectiveness of a community-based Symptoms Clinic intervention in people with mul…
View article: Accuracy of the National Early Warning Score version 2 (NEWS2) in predicting need for time-critical treatment: retrospective observational cohort study
Accuracy of the National Early Warning Score version 2 (NEWS2) in predicting need for time-critical treatment: retrospective observational cohort study Open
Background Initial ED assessment can use early warning scores to identify and prioritise patients who need time-critical treatment. We aimed to determine the accuracy of the National Early Warning Score version 2 (NEWS2) for predicting the…
View article: Accuracy of the National Early Warning Score version 2 (NEWS2) in predicting need for time-critical treatment: Retrospective observational cohort study
Accuracy of the National Early Warning Score version 2 (NEWS2) in predicting need for time-critical treatment: Retrospective observational cohort study Open
Background Initial emergency department (ED) assessment can use early warning scores to identify and prioritise patients who need time-critical treatment. We aimed to determine the accuracy of the National Early Warning Score version 2 (NE…
View article: Adapting the stroke therapy outcome measure for use by Multidisciplinary Teams: considering reliability
Adapting the stroke therapy outcome measure for use by Multidisciplinary Teams: considering reliability Open
The Stroke MDT TOMs is psychometrically robust and should assist with improving team work in the rehabilitation of stroke patients and their carers. Future research may use MDT Stroke TOM to promote interprofessional team working and facil…
View article: Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study
Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study Open
Background Guidelines for sepsis recommend treating those at highest risk within 1 hour. The emergency care system can only achieve this if sepsis is recognised and prioritised. Ambulance services can use prehospital early warning scores a…
View article: 2109 Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study
2109 Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study Open
Aims and Objectives Ambulance services need to identify and prioritise patients with sepsis for early hospital assessment. We aimed to determine the accuracy of early warning scores alongside paramedic diagnostic impression to identify sep…
View article: SWAT 137: A 2x2 randomised factorial SWAT of the use of a pen and brief information leaflet to improve recruitment in a randomised controlled trial of a community-based clinic for patients with persistent physical symptoms
SWAT 137: A 2x2 randomised factorial SWAT of the use of a pen and brief information leaflet to improve recruitment in a randomised controlled trial of a community-based clinic for patients with persistent physical symptoms Open
Background Many strategies are used by trialists to improve recruitment, but few have been tested. We aimed to evaluate two interventions: 1) a study branded pen and 2) brief participant information leaflet, included within invitation pack…
View article: Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study
Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study Open
Background Ambulance services need to identify and prioritise patients with sepsis for early hospital assessment. We aimed to determine the accuracy of early warning scores alongside paramedic diagnostic impression to identify sepsis that …
View article: A model-based economic analysis of the CFHealthHub intervention to support adherence to inhaled medications for people with cystic fibrosis in the UK
A model-based economic analysis of the CFHealthHub intervention to support adherence to inhaled medications for people with cystic fibrosis in the UK Open
Background Adherence to preventative inhaled therapies in people with cystic fibrosis (CF) is low, resulting in potentially avoidable health losses and the need for costly rescue therapies. Objectives To estimate the cost-effectiveness of …
View article: Pre-hospital prediction of adverse outcomes in patients with suspected COVID-19: Development, application and comparison of machine learning and deep learning methods
Pre-hospital prediction of adverse outcomes in patients with suspected COVID-19: Development, application and comparison of machine learning and deep learning methods Open
These methods could potentially reduce the numbers of patients conveyed to hospital without a concomitant increase in adverse outcomes. Further work is required to test the models externally and develop an automated system for use in clini…
View article: Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: an observational cohort study
Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: an observational cohort study Open
Objective To assess accuracy of emergency medical service (EMS) telephone triage in identifying patients who need an EMS response and identify factors which affect triage accuracy. Design Observational cohort study. Setting Emergency telep…
View article: Review of samples sizes used in agreement studies published in the PubMed database
Review of samples sizes used in agreement studies published in the PubMed database Open
Introduction: A sample size justification is required for all studies and should give the minimum number of subjects to be recruited for the study to achieve its primary objective. This aim of this review is to describe sample sizes from a…
View article: Accuracy of telephone triage for predicting adverse outcomes in suspected COVID-19: an observational cohort study
Accuracy of telephone triage for predicting adverse outcomes in suspected COVID-19: an observational cohort study Open
Objective To assess accuracy of telephone triage in identifying need for emergency care among those with suspected COVID-19 infection and identify factors which affect triage accuracy. Design Observational cohort study. Setting Community t…
View article: Composite Outcomes in Clinical Prediction Modeling: Are We Trying to Predict Apples and Oranges?
Composite Outcomes in Clinical Prediction Modeling: Are We Trying to Predict Apples and Oranges? Open
Composite outcomes are widely used in clinical research. Existing literature has considered the pros and cons of composite outcomes in clinical trials, but their extensive use in clinical prediction has received much less attention. Clinic…
View article: 867 Prognostic accuracy of triage tools for adults with suspected COVID-19 in a pre-hospital setting: an observational cohort study
867 Prognostic accuracy of triage tools for adults with suspected COVID-19 in a pre-hospital setting: an observational cohort study Open
Aims/Objectives/Background Emergency Medical Service (EMS) and other practitioners assessing patients with suspected COVID-19 in the community must rapidly determine whether patients need treatment in hospital or can self-care. Tools to tr…
View article: Prognostic accuracy of triage tools for adults with suspected COVID-19 in a prehospital setting: an observational cohort study
Prognostic accuracy of triage tools for adults with suspected COVID-19 in a prehospital setting: an observational cohort study Open
Background Tools proposed to triage patient acuity in COVID-19 infection have only been validated in hospital populations. We estimated the accuracy of five risk-stratification tools recommended to predict severe illness and compared accur…
View article: Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT
Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT Open
Background People with cystic fibrosis are susceptible to pulmonary infection with Pseudomonas aeruginosa . This may become chronic and lead to increased mortality and morbidity. If treatment is commenced promptly, infection may be eradica…
View article: Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: An observational cohort study
Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: An observational cohort study Open
Background Emergency Medical Services (EMS) have experienced surges in demand as the COVID-19 pandemic has progressed with ambulances services in the UK declaring major incidents due to the risk of care being compromised. COVID-19 specific…
View article: An intervention to support adherence to inhaled medication in adults with cystic fibrosis: the ACtiF research programme including RCT
An intervention to support adherence to inhaled medication in adults with cystic fibrosis: the ACtiF research programme including RCT Open
Background People with cystic fibrosis frequently have low levels of adherence to inhaled medications. Objectives The objectives were to develop and evaluate an intervention for adults with cystic fibrosis to improve adherence to their inh…
View article: Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial
Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial Open
Introduction Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We inves…
View article: Accuracy of telephone triage for predicting adverse outcome in suspected COVID-19: An observational cohort study
Accuracy of telephone triage for predicting adverse outcome in suspected COVID-19: An observational cohort study Open
Objective To assess accuracy of telephone triage in identifying patients who need emergency care amongst those with suspected COVID-19 infection and identify factors which affect triage accuracy. Design Observational cohort study Setting C…
View article: Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study
Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study Open
Background The WHO and National Institute for Health and Care Excellence recommend various triage tools to assist decision-making for patients with suspected COVID-19. We aimed to compare the accuracy of triage tools for predicting severe …
View article: Do not attempt cardiopulmonary resuscitation (DNACPR) decisions in people admitted with suspected COVID-19: Secondary analysis of the PRIEST observational cohort study
Do not attempt cardiopulmonary resuscitation (DNACPR) decisions in people admitted with suspected COVID-19: Secondary analysis of the PRIEST observational cohort study Open
ISRCTN registry, ISRCTN28342533, http://www.isrctn.com/ISRCTN28342533.
View article: Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study
Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study Open
Objectives We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely ill adults with suspected COVID-19 infection. Methods We undertook a mixed prospective and retrospectiv…
View article: Post-exertion oxygen saturation as a prognostic factor for adverse outcome in patients attending the emergency department with suspected COVID-19: a substudy of the PRIEST observational cohort study
Post-exertion oxygen saturation as a prognostic factor for adverse outcome in patients attending the emergency department with suspected COVID-19: a substudy of the PRIEST observational cohort study Open
Background Measurement of post-exertion oxygen saturation has been proposed to assess illness severity in suspected COVID-19 infection. We aimed to determine the accuracy of post-exertional oxygen saturation for predicting adverse outcome …
View article: Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study
Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study Open
Background Hospital emergency departments play a crucial role in the initial assessment and management of suspected COVID-19 infection. This needs to be guided by studies of people presenting with suspected COVID-19, including those admitt…