Laura Bucci
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View article: Outcome of hepatic resection for HCC in ideal and non-ideal candidates
Outcome of hepatic resection for HCC in ideal and non-ideal candidates Open
Background: The Barcelona Clinic Liver Cancer staging system considers, among patients with HCC, “ideal candidates” (ICs) for hepatic resection (HR) those with a single lesion, normal bilirubin, and without clinically significant portal hy…
View article: Effects of different B-cell-depleting strategies on the lymphatic tissue
Effects of different B-cell-depleting strategies on the lymphatic tissue Open
Protein-based B cell depletion reduces but usually does not deplete B cells in lymph nodes leaving the follicular architecture intact and being associated with disease recurrence.
View article: Recurrence rate, features, and outcome after hepatocellular carcinoma curative resection or ablation according to the IMbrave050 criteria: a real-world study
Recurrence rate, features, and outcome after hepatocellular carcinoma curative resection or ablation according to the IMbrave050 criteria: a real-world study Open
View article: Characteristics and Outcomes of Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis
Characteristics and Outcomes of Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis Open
View article: Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with autoimmune disease: an observational study
Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with autoimmune disease: an observational study Open
Deutsche Forschungsgemeinschaft (DFG), German Cancer Aid, Bundesministerium für Bildung und Forschung, European Union, Staedtler Foundation, Lupus Research Alliance, and donations from the Bendel family and the Bleyl family.
View article: BCMA CAR T cells in a patient with relapsing idiopathic inflammatory myositis after initial and repeat therapy with CD19 CAR T cells
BCMA CAR T cells in a patient with relapsing idiopathic inflammatory myositis after initial and repeat therapy with CD19 CAR T cells Open
CD19 chimeric antigen receptor (CD19 CAR) T cell therapy has been shown to induce stable drug-free remission in patients with refractory autoimmune disease. The management of potential relapses is currently unclear. Here we report on a 45-…
View article: Absence of Viral Replication Is Associated With Improved Outcome in Anti‐<scp>HCV</scp>‐Positive Patients With Hepatocellular Carcinoma
Absence of Viral Replication Is Associated With Improved Outcome in Anti‐<span>HCV</span>‐Positive Patients With Hepatocellular Carcinoma Open
Background and Aims Presence of active hepatitis C virus (HCV) infection may influence the outcome of patients treated for hepatocellular carcinoma (HCC), although this issue has never been adequately assessed in a large series of patients…
View article: CD19-CAR T-cell therapy induces deep tissue depletion of B cells
CD19-CAR T-cell therapy induces deep tissue depletion of B cells Open
View article: Liver Resection vs Nonsurgical Treatments for Patients With Early Multinodular Hepatocellular Carcinoma
Liver Resection vs Nonsurgical Treatments for Patients With Early Multinodular Hepatocellular Carcinoma Open
Importance The 2022 Barcelona Clinic Liver Cancer algorithm currently discourages liver resection (LR) for patients with multinodular hepatocellular carcinoma (HCC) presenting with 2 or 3 nodules that are each 3 cm or smaller. Objective To…
View article: Characteristics and outcome of anti‐hepatitis D virus positive patients with hepatocellular carcinoma
Characteristics and outcome of anti‐hepatitis D virus positive patients with hepatocellular carcinoma Open
Background & Aims Chronic hepatitis D virus (HDV) often leads to end‐stage liver disease and hepatocellular carcinoma (HCC). Comprehensive data pertaining to large populations with HDV and HCC are missing, therefore we sought to assess the…
View article: Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs
Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs Open
Alcohol abuse is a leading and growing cause of hepatocellular carcinoma (HCC) worldwide and is associated with a worse prognosis compared with other aetiologies. We assessed the evolutionary landscape of alcohol-related HCC over 15 years …
View article: Serological Response to BNT162b2 Anti-SARS-CoV-2 Vaccination in Patients with Inflammatory Rheumatic Diseases: Results From the RHEUVAX Cohort
Serological Response to BNT162b2 Anti-SARS-CoV-2 Vaccination in Patients with Inflammatory Rheumatic Diseases: Results From the RHEUVAX Cohort Open
Objective In the light of the current COVID-19 epidemic and the availability of effective vaccines, this study aims to identify factors associated with non-response to anti-SARS-CoV-2 vaccines as immunological alteration associated with im…
View article: Humoral and Cellular Immune Responses to SARS–CoV‐2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion
Humoral and Cellular Immune Responses to SARS–CoV‐2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion Open
Objective B cell depletion is an established therapeutic principle in a wide range of autoimmune diseases. However, B cells are also critical for inducing protective immunity after infection and vaccination. We undertook this study to asse…
View article: Does methotrexate influence COVID-19 infection? Case series and mechanistic data
Does methotrexate influence COVID-19 infection? Case series and mechanistic data Open
Background To investigate whether methotrexate treatment may affect the susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods Clinical assessment of symptoms, SARS-CoV-2 RNA, and anti-SARS-C…
View article: Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis
Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis Open
To avoid autoimmunity, it is essential to keep the balance between the defence against pathogens and the maintenance of tolerance to self‐antigens. Mucosal inflammation may lead to breakdown of tolerance and activation of autoreactive cell…
View article: Novel immune cell phenotypes in spondyloarthritis pathogenesis
Novel immune cell phenotypes in spondyloarthritis pathogenesis Open
Spondyloarthritis (SpA) is a heterogeneous group of chronic inflammatory diseases of unknown etiology. Over time, the plethora of cellular elements involved in its pathogenesis has progressively enriched together with the definition of spe…
View article: Twelve-Week Daily Consumption of ad hoc Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial
Twelve-Week Daily Consumption of ad hoc Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial Open
Background and Aim: A state of chronic, subclinical inflammation known as inflammaging is present in elderly people and represents a risk factor for all age-related diseases. Dietary supplementation with ad hoc fortified foods seems an app…
View article: Biomarker panels may be superior over single molecules in prediction of renal flares in systemic lupus erythematosus: an exploratory study
Biomarker panels may be superior over single molecules in prediction of renal flares in systemic lupus erythematosus: an exploratory study Open
Objective Recent evidence suggests that some urinary biomarkers, namely Vascular Cell Adhesion Molecule-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1), Monocyte Chemoattractant Protein 1 (MCP-1), Neutrophil Gelatinase Associated Li…
View article: Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality
Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality Open
Thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) were evaluated in a population of 672 well-characterized Italian subjects (age range: 52-113 years), including an unprecedented number of centenarians, semi-supercentenarian…
View article: Restaging Patients With Hepatocellular Carcinoma Before Additional Treatment Decisions: A Multicenter Cohort Study
Restaging Patients With Hepatocellular Carcinoma Before Additional Treatment Decisions: A Multicenter Cohort Study Open
Prognostic assessment of patients with hepatocellular carcinoma (HCC) at the time of diagnosis remains controversial and becomes even more complex at the time of restaging when new variables need to be considered. The aim of the current st…
View article: Utility of Tumor Burden Score to Stratify Prognosis of Patients with Hepatocellular Cancer: Results of 4759 Cases from ITA.LI.CA Study Group
Utility of Tumor Burden Score to Stratify Prognosis of Patients with Hepatocellular Cancer: Results of 4759 Cases from ITA.LI.CA Study Group Open
View article: Patients with advanced hepatocellular carcinoma need a personalized management: A lesson from clinical practice
Patients with advanced hepatocellular carcinoma need a personalized management: A lesson from clinical practice Open
The Barcelona Clinic Liver Cancer (BCLC) advanced stage (BCLC C) of hepatocellular carcinoma (HCC) includes a heterogeneous population, where sorafenib alone is the recommended treatment. In this study, our aim was to assess treatment and …
View article: Hepatic decompensation is the major driver of death in HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma
Hepatic decompensation is the major driver of death in HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma Open
View article: The evolutionary scenario of hepatocellular carcinoma in Italy: an update
The evolutionary scenario of hepatocellular carcinoma in Italy: an update Open
Background & Aims Epidemiology of hepatocellular carcinoma is changing worldwide. This study aimed at evaluating the changing scenario of aetiology, presentation, management and prognosis of hepatocellular carcinoma in Italy during the las…
View article: Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview
Centenarians’ offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview Open
Within the scenario of an increasing life expectancy worldwide it is mandatory to identify determinants of healthy aging. Centenarian offspring (CO) is one of the most informative model to identify trajectories of healthy aging and their d…