Laura Capasso
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Pervasive tandem duplications and convergent evolution shape coral genomes Open
Over the last decade, several coral genomes have been sequenced allowing a better understanding of these symbiotic organisms threatened by climate change. Scleractinian corals are reef builders and are central to these ecosystems, providin…
Telomere dysfunction is associated to dark-induced coral bleaching in the reef coral Stylophora pistillata Open
Telomere DNA length is a complex trait controlled both by multiple loci and environmental factors. Even though the use of telomere DNA length measurement, as a method of assessing stress accumulation and predicting how this will influence …
Intracellular pH Regulation: Characterization and Functional Investigation of H+ Transporters in Stylophora Pistillata Open
Background: Reef-building corals regularly experience changes in intra and extracellular H+ concentration ([H+]) due to physiological and environmental processes. Stringent control of [H+] is required for the maintenance of homeostatic aci…
Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Overall, this work highlights modifications of the transcriptional landscape in human bronchial cells exposed to UFP and sheds new lights on possible mechanisms by means of which UFP acts as a carcinogen and harmful factor for human health.
Additional file 11: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S7. Genes identified by maSigPro as differentially modulated in time during the exposure to biomass or diesel UFP, respectively. (XLS 66Â kb)
Additional file 7: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S4. Fold change of genes differentially expressed by the exposure to both diesel and biomass UFP. (XLS 67Â kb)
Additional file 9: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S5. Functional enrichment of gene sets from GSEA Hallmarks collection in cells exposed to diesel UFP. (XLS 48Â kb)
Additional file 3: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S1. Total number of reads and number and percentage of reads mapped by TopHat in each analyzed sample. (XLS 39Â kb)
Additional file 13: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S8. Detail of the filtering criteria for each of the DEGs from network analysis (Fig. 4); for each gene, the number of significant time points, presence in the core enrichment of the selected GSEA hallmarks or the number of Pubmed pu…
Additional file 10: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S6. Functional enrichment of gene sets from GSEA Hallmarks collection in cells exposed to biomass UFP. (XLS 49Â kb)
Additional file 14: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S9. Biological interactions of genes from network analysis (Fig. 4 and Additional file 15: Figure S6) according to the Reactome FI database; for each interaction, the type of regulation and the score are indicated. Scores range fro…
Additional file 6: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S3. FC and p-value of the genes differentially expressed after exposure to UFP from biomass combustion (as compared to controls) at the different time points. (XLS 3855Â kb)
Additional file 5: of Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles Open
Table S2. FC and p-value of the genes differentially expressed after exposure to UFP from diesel combustion (as compared to controls) at the different time points. (XLS 3855Â kb)