Laura Ciudad
YOU?
Author Swipe
View article: COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation
COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation Open
View article: NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment
NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment Open
Macrophages orchestrate tissue homeostasis and immunity. In the tumor microenvironment (TME), macrophage presence is largely associated with poor prognosis because of their reprogramming into immunosuppressive cells. We investigated the ef…
View article: Purinergic exposure induces epigenomic and transcriptomic-mediated preconditioning resembling epilepsy-associated microglial states
Purinergic exposure induces epigenomic and transcriptomic-mediated preconditioning resembling epilepsy-associated microglial states Open
Microglia play a crucial role in a range of neuropathologies through exacerbated activation. Microglial inflammatory responses can be influenced by prior exposures to noxious stimuli, like increased levels of extracellular adenosine and AT…
View article: Interplay between T-bet and HIF-1a is required for proper epigenomic and transcriptomic reprogramming of monocyte subsets
Interplay between T-bet and HIF-1a is required for proper epigenomic and transcriptomic reprogramming of monocyte subsets Open
Background: Monocyte subsets, classified into classical, intermediate, and non-classical, have distinct specific functions. Despite increasing reports describing changes in monocyte subsets in a wide range of pathological inflammatory cond…
View article: Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes
Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes Open
Our study suggests the participation of novel cytokines and pathways and the occurrence of a disruption of monocyte-T cell crosstalk driving GCA pathogenesis.
View article: Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands
Tinostamustine (EDO-S101), an Alkylating Deacetylase Inhibitor, Enhances the Efficacy of Daratumumab in Multiple Myeloma by Upregulation of CD38 and NKG2D Ligands Open
Multiple myeloma is a malignancy characterized by the accumulation of malignant plasma cells in bone marrow and the production of monoclonal immunoglobulin. A hallmark of cancer is the evasion of immune surveillance. Histone deacetylase in…
View article: Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection
Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection Open
In COVID‐19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre‐existing autoimmune conditions can therefore be at increased risk of severe COVID‐19 and/or associated sequelae, yet SARS‐CoV‐2 infe…
View article: Purinergic Preconditioning Induces Epigenomic and Transcriptomic Changes Resembling Epilepsy-associated Microglial States
Purinergic Preconditioning Induces Epigenomic and Transcriptomic Changes Resembling Epilepsy-associated Microglial States Open
Microglia, as the main immune effector cells in the central nervous system (CNS), play a crucial role in a diverse range of neuropathological conditions through their exacerbated activation. Microglial inflammatory responses can be influen…
View article: POS0093 TRANSCRIPTOMIC AND METHYLOMIC PROFILING OF CD4+ T-CELLS IN GIANT CELL ARTERITIS WITH DIFFERENT DISEASE ACTIVITY
POS0093 TRANSCRIPTOMIC AND METHYLOMIC PROFILING OF CD4+ T-CELLS IN GIANT CELL ARTERITIS WITH DIFFERENT DISEASE ACTIVITY Open
View article: Data from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells
Data from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells Open
Transcription factors are common targets of epigenetic inactivation in human cancer. Promoter hypermethylation and subsequent silencing of transcription factors can lead to further deregulation of their targets. In this study, we explored …
View article: Data from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells
Data from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells Open
Transcription factors are common targets of epigenetic inactivation in human cancer. Promoter hypermethylation and subsequent silencing of transcription factors can lead to further deregulation of their targets. In this study, we explored …
View article: Supplementary Figures 1-3, Tables 1-2 from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells
Supplementary Figures 1-3, Tables 1-2 from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells Open
PDF file - 273K
View article: Supplementary Figures 1-3, Tables 1-2 from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells
Supplementary Figures 1-3, Tables 1-2 from Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells Open
PDF file - 273K
View article: Purinergic Preconditioning Induces Epigenomic and Transcriptomic-Mediated Training Resembling Epilepsy-Associated Microglial States
Purinergic Preconditioning Induces Epigenomic and Transcriptomic-Mediated Training Resembling Epilepsy-Associated Microglial States Open
View article: Additional file 4 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Additional file 4 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy Open
Additional file. 4. Meth_atlas output. Estimated cell and tissue proportions of contribution for all samples.
View article: Additional file 5 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Additional file 5 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy Open
Additional file. 5. Meth_atlas output. Estimated cell and tissue proportions of contribution for all samples.
View article: Additional file 6 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Additional file 6 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy Open
Additional file 6. Differentially methylated regions (DMRs) in cfDNA of MTLE patients in comparison with controls.
View article: Additional file 7 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Additional file 7 of Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy Open
Additional file 7. List of DNase-seq data sets obtained from the ENCODE.
View article: Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy Open
Background DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns and the direct relati…
View article: Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines Open
Background COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, esp…
View article: Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study Open
Introduction. This study aimed to evaluate whether early vitamin C and thiamine administration was associated with a lower 28-day and in-hospital mortality in surgical critically ill patients with refractory septic shock. Patients and meth…
View article: COVID-19 progression and convalescence in common variable immunodeficiency patients shows incomplete adaptive responses and persistent inflammasome activation
COVID-19 progression and convalescence in common variable immunodeficiency patients shows incomplete adaptive responses and persistent inflammasome activation Open
View article: Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells Open
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective activation of naïve T cells. DCs’ immunological properties are modulated in response to various stimuli. Active DNA demethylation is crucial for D…
View article: Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines Open
COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially mon…
View article: Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy Open
Background: DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns and the direct relat…
View article: Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids
Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids Open
View article: Vitamin C triggers NF-κB-driven epigenomic reprogramming and enhanced immunogenic responses of dendritic cells
Vitamin C triggers NF-κB-driven epigenomic reprogramming and enhanced immunogenic responses of dendritic cells Open
Dendritic cells (DCs) are central in the immune system, bridging the adaptive and innate immune responses. Research on in vitro differentiation of DCs from monocytes provides both in-depth understanding of the analogous in vivo process and…
View article: Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses Open
View article: The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis
The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis Open
Identifying predictive biomarkers at early stages of inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes (MOs) and macrophages, largely associated with arthritis, are contributors and sens…
View article: Circulating Cell-Free DNA Methylation Mirrors Alterations In Cerebral Patterns in Epilepsy
Circulating Cell-Free DNA Methylation Mirrors Alterations In Cerebral Patterns in Epilepsy Open