Laura Esposito YOU? Author Swipe

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Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy Open

Qian Li, Andrew Sharkey, Megan A. Sheridan, Elisa Magistrati, Anna Arutyunyan , et al. · 2024

Successful placentation in human pregnancy is regulated by reciprocal interactions between maternal uterine NK cells and fetal placental trophoblast Open

Qian Li, Andrew Sharkey, Megan A. Sheridan, Elisa Magistrati, Anna Arutyunyan , et al. · 2023

Summary Fetal growth and development during human pregnancy depends on delivery of adequate maternal oxygen and nutrients to the fetus via the placenta. In humans, the balanced invasion of fetal placental trophoblast cells into the materna…

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy? Open

Oisín Huhn, Xiaohui Zhao, Laura Esposito, Ashley Moffett, Francesco Colucci , et al. · 2021

Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they con…

Trophoblast organoids as a model for maternal–fetal interactions during human placentation Open

Margherita Y. Turco, Lucy Gardner, Richard G. Kay, Russell S. Hamilton, Malwina Prater , et al. · 2018

DILT1D study profile and adaptive design. Open

Arlene John, Marina Evangelou, J. Cutler Antony, L. Pekalski Marcin, M. Walker Neil , et al. · 2016

(A) Flow chart showing the allocation of participants to the three predefined study populations: evaluable, safety, and analysis. (B) The study was conducted in two phases, a learning phase (140 d) and an adaptive phase (240 d). Individual…

Participant characteristics and autoantibody status. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

Regulatory T cell primary endpoint. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A) Percentage of Tregs was defined as the percentage of CD3⁺CD4⁺CD25^highCD127^low cells within the CD3⁺CD4⁺ gate measured. (B) Individual participant dose allocations and do…

Lymphocyte responses to a dose of aldesleukin. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A) Average response curves of the absolute change in lymphocyte count across the five dose groups (average baseline lymphocyte count 1.78 × 10⁹/l, SE = 0.08, range 0.95–3.84, n = 39). (B) Three-dimensional plot of dose, …

Effects of aldesleukin on NK CD56<sup>bright</sup> cell number, phenotypes, and proliferation. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A and B) NK CD56^bright cells showed a rapid dose-dependent decline, with the majority of cells not in circulation at 90 min (NK CD56^bright cells percent of lymphocytes: 0.41%, SE = 0.03%, range 0.09%–0.96%, n …

Hyperacute regulatory T cell response to aldesleukin. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A) Treg proportions as a percent of CD4⁺ T cells (average Treg level 6.6%, SE = 0.2%, range 3.5%–10.7%, n = 39) and (B) Treg counts following injection of aldesleukin as measured by the clinical grade FACS assay in conju…

Phenotypes of the residual circulating regulatory T cells at day 1. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A and B) CD25 expression was increased on mTregs (average baseline CD25 MFI on mTreg = 7,412, SE = 181, range 5,119–9,393, n = 37). (C and D) Concurrently, there was a dose-dependent reduction in CD122 on mTregs in blood (baseline …

Effects of aldesleukin on effector T cell number, phenotypes, and proliferation. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A) mTeffs were responsive to aldesleukin, with their frequencies as a percentage of non-regulatory CD4⁺ T cells altered in circulation (B), resulting in opposing effects, with lower doses leading to higher mTeff frequencies and…

Aldesleukin upregulates CXCR3 and CCR6 on regulatory T cells. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A and B) Dose-dependent sustained increase in expression of CXCR3 on mTregs (CXCR3 average baseline MFI 2252 (45.08; 1783–3193) n = 35). (C and D) The increase in CCR6 expression by mTregs was maximal and dose dependent on Day 1 (C…

Eosinophil response depends on baseline counts and aldesleukin dose. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A) Eosinophil counts showed an initial transient decrease at 90 min in a hyperacute response to aldesleukin followed by a dose-dependent increase on day 1, with a return to baseline by day 3–4 (average baseline eosinophil count 0.15 × 10<…

In vivo regulatory T cell phenotypes and functional responses to aldesleukin. Open

A. Todd John, Marina Evangelou, J. Cutler Antony, Marcin Łuszczyk, M. Walker Neil , et al. · 2016

(A and B) mTregs had their maximum pSTAT5 response to treatment at 90 min, and a detectable response was sustained for up to 4 d at the higher doses and was dose dependent on day 1 with a cubic dose response (average baseline pSTAT5 MFI = …

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial Open

John A. Todd, Marina Evangelou, Antony J. Cutler, Marcin Ł. Pękalski, Neil Walker , et al. · 2016

BACKGROUND: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive CD4+ effector…

Replication kinetics of poliovirus infection of suspension PER.C6cells with a cell density of 10<sup>7</sup> cells/ml at an MOI of 1 at 30°C and 37°C harvested between 0–48 hours post infection. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Viruses used were Brunenders, Brunenders—with 14 CAVA mutations, MEF-1, MEF-1 –with 14 CAVA mutations, Sabin 3, Sabin 3 –with 14 CAVA mutations and the CAVA backbone virus (see overview of all viruses in Fig 2). The Sabin 3/Sabin 3–14 infe…

Infectious titers and <i>in vivo</i> neurovirulence after intra cerebral inoculation of the CAVA vaccine strains as compared to the cIPV and Sabin strains. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Bockstal Viki, Tobias Kamphuis , et al. · 2016

Infectious titers and in vivo neurovirulence after intra cerebral inoculation of the CAVA vaccine strains as compared to the cIPV and Sabin strains.

Reversion of the temperature sensitive phenotype by stepwise increase of the infection temperature. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Bockstal Viki, Tobias Kamphuis , et al. · 2016

Serial passage was performed using CAVA-1 Mahoney in suspension PER.C6 cells infected at a cell density of 10⁷ cells/ml at low MOI (0.01) and harvested at 3–4 days post infection. Temperature was gradually increased (33–37°C) or…

<i>In vivo</i> immunogenicity of the CAVA vaccine strains as compared to cIPV. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Groups of ten (n = 10) rats were immunized with a full dose (FD: 100% 40:8:32 DU/dose or 150% 60:12:48 DU/dose) or a 1:2, 1:4 or 1:16 dilution of the full dose. Poliovirus type 1, 2 and 3-specific neutralizing antibody titers were determin…

Electron micrographs of two representative cells per panel after infection of suspension PER.C6 cells with a cell density of 10<sup>7</sup> cells/ml at an MOI of 1, harvested between 24–48 hours post infection. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Panel A) PBS (Mock) infected cells, Panel B) Mahoney infection at 37°C, Panel C) CAVA-1 Mahoney at 37°C, Panel D) CAVA-1 Mahoney at 30°C.

Quantification of poliovirus infectious units (by infectious titer determination, Panel A), viral RNA levels (by RTqPCR, Panel B) and viral proteins (by Western blot, Panel C) after infection of suspension PER.C6 cells with a cell density of 10<sup>7</sup> cells/ml at an MOI of 1 at 30°C and 37°C, harvested between 0–48 hours post infection. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Viruses used were Brunenders (WT), Brunenders with the CAVA mutations in the IRES (IRES), Brunenders with the CAVA mutations in the Non-Structural proteins (NS), the CAVA-1 Mahoney (C1) vaccine strain and the CAVA backbone virus (CBB); Con…

Multiple replication kinetics of infections in PER.C6 cells with a cell density of 10<sup>7</sup> cells/ml at an MOI of 1–2, at 30°C and 37°C, harvested at 0–48 hours post infection. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Panel A) Average and standard deviation of two (n = 2) replication kinetic curves of the Brunenders strain versus 3 selected clones (clone A, B and C) derived after passage with impaired growth at 37°C. Panel B) Average and standard deviat…

Schematic overview of the viruses described here and their incorporated mutations. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Black vertical lines represent the synonymous CAVA mutations whilst red vertical lines represent non-synonymous CAVA mutations, dispersed over the poliovirus genome; a detailed description of the individual mutations is given in S1 Table. …

Secondary RNA structure prediction of Domain II and Domain VI of the IRES in Brunenders and CAVA using the MFOLD program developed by M. Zuker. Open

P. Sanders Barbara, de los Rios Oakes Isabel, van Hoek Vladimir, Viki Bockstal, Tobias Kamphuis , et al. · 2016

Circled nucleotides (at positions 133, 142, 146, and 163 in domain II and at positions 597, 609 in domain VI) represent nucleotide changes between CAVA and Brunenders. The last remaining CAVA IRES mutation (nt579) lies outside of any IRES …

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