Laura DeVault
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View article: The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism
The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism Open
Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration…
View article: The response of Dual-leucine zipper kinase (DLK) to nocodazole: evidence for a homeostatic cytoskeletal repair mechanism
The response of Dual-leucine zipper kinase (DLK) to nocodazole: evidence for a homeostatic cytoskeletal repair mechanism Open
Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration…
View article: Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy Open
TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most patients with amyotrophic lateral sclerosis (ALS). To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we …
View article: Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy Open
Summary TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most ALS patients. To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated constitutive and co…
View article: Author response: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development
Author response: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Sensory n…
View article: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development.
Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development. Open
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral tra…
View article: Steroid hormone signaling activates thermal nociception during <i>Drosophila</i> peripheral nervous system development
Steroid hormone signaling activates thermal nociception during <i>Drosophila</i> peripheral nervous system development Open
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral tra…
View article: Dendrite regeneration of adult <i>Drosophila</i> sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2
Dendrite regeneration of adult <i>Drosophila</i> sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2 Open
Dendrites possess distinct structural and functional properties that enable neurons to receive information from the environment as well as other neurons. Despite their key role in neuronal function, current understanding of the ability of …
View article: Characterization of Dendrite Development and Regeneration
Characterization of Dendrite Development and Regeneration Open
Despite their key role in neuronal function, current understanding of dendrite development and regeneration are lacking. We focused on the class IV dendritic arborization (c4da) neuron of the Drosophila sensory system to address aspects of…
View article: Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons
Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons Open
View article: In vivo dendrite regeneration after injury is different from dendrite development
In vivo dendrite regeneration after injury is different from dendrite development Open
Neurons receive information along dendrites and send signals along axons to synaptic contacts. The factors that control axon regeneration have been examined in many systems, but dendrite regeneration has been largely unexplored. Here we re…
View article: RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization
RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization Open
Formation of elaborately branched dendrites is necessary for the proper input and connectivity of many sensory neurons. Previous studies have revealed that dendritic growth relies heavily on ER-to-Golgi transport, Golgi outposts and endocy…