Laura Emptage
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View article: Dye Free Polarized Light Differentiation of Protein Deposits in Post‐mortem Retinas of Individuals with FTLD and ALS compared to those with Alzheimer's Disease
Dye Free Polarized Light Differentiation of Protein Deposits in Post‐mortem Retinas of Individuals with FTLD and ALS compared to those with Alzheimer's Disease Open
Background Our non‐invasive retinal imaging, using polarized light, identifies protein deposits which predict brain pathology. Previously, our measured polarized light interactions differed between retinal deposits in Alzheimer's disease (…
View article: Retinal Deposits of TDP‐43 and Amyloid Beta and Associated Neurodegenerative Diseases are Accurately Classified using Measured Interactions with Polarized Light in Machine Learning Algorithms
Retinal Deposits of TDP‐43 and Amyloid Beta and Associated Neurodegenerative Diseases are Accurately Classified using Measured Interactions with Polarized Light in Machine Learning Algorithms Open
Background We have shown that interactions with polarized light differed significantly between retinal amyloid beta deposits, associated with Alzheimer’s disease, and deposits of TDP‐43 found in the neurodegenerative diseases Frontotempora…
View article: Retinal imaging in polarized light of two different protein deposit types found in the retina in different neurodegeneration diseases (NDDs)
Retinal imaging in polarized light of two different protein deposit types found in the retina in different neurodegeneration diseases (NDDs) Open
Background Amyloid and alpha synuclein proteins are brain biomarkers of different neurodegenerative diseases, many years before symptoms. We have shown that imaging dye‐free with polarized light makes retinal amyloid deposits visible as a …
View article: The visibility of retinal amyloid deposits as a biomarker of Alzheimer’s disease when imaged in polarized light through the cornea
The visibility of retinal amyloid deposits as a biomarker of Alzheimer’s disease when imaged in polarized light through the cornea Open
Background We previously reported a novel, dye‐free method to image amyloid deposits in the retina. Using polarized light interactions to create deposit contrast, the number of deposits in ex vivo retinas predicted the severity of brain am…
View article: Analysis of amyloid deposits in the retina and implications for use as a biomarker of Alzheimer’s Disease
Analysis of amyloid deposits in the retina and implications for use as a biomarker of Alzheimer’s Disease Open
Background In humans and the naturally occurring canine model of Alzheimer’s disease (AD), we and others observe amyloid deposits in the retina en face. We have previously shown that detecting the number of amyloid deposits with polarised …
View article: Characterization of amyloid angiopathy in the retina
Characterization of amyloid angiopathy in the retina Open
Background Cerebral amyloid angiopathy (CAA) is a vascular brain disease with risk of severe complications, and high prevalence in those with Alzheimer’s disease (AD). Characteristic amyloid beta deposits in blood vessels in the cerebrum a…
View article: IC‐P‐135: DISTRIBUTION OF AMYLOID DEPOSITS ACROSS THE RETINA IN ASSOCIATION WITH ALZHEIMER'S DISEASE AS A FUNCTION OF DISEASE SEVERITY
IC‐P‐135: DISTRIBUTION OF AMYLOID DEPOSITS ACROSS THE RETINA IN ASSOCIATION WITH ALZHEIMER'S DISEASE AS A FUNCTION OF DISEASE SEVERITY Open
In Alzheimer's disease (AD), amyloid deposits have been reported primarily in the far peripheral retina. We reported that the number of retinal amyloid deposits correlates with the severity of AD pathology in the brain. In polarimetry imag…
View article: P2‐262: DISTRIBUTION OF AMYLOID DEPOSITS ACROSS THE RETINA IN ASSOCIATION WITH ALZHEIMER'S DISEASE AS A FUNCTION OF DISEASE SEVERITY
P2‐262: DISTRIBUTION OF AMYLOID DEPOSITS ACROSS THE RETINA IN ASSOCIATION WITH ALZHEIMER'S DISEASE AS A FUNCTION OF DISEASE SEVERITY Open
In Alzheimer's disease (AD), amyloid deposits have been reported primarily in the far peripheral retina. We reported that the number of retinal amyloid deposits correlates with the severity of AD pathology in the brain. In polarimetry imag…
View article: [P1–116]: THE RELATIONSHIP BETWEEN AMYLOID IN THE RETINA AND A BRAIN‐BASED POST‐MORTEM DIAGNOSIS OF ALZHEIMER's DISEASE
[P1–116]: THE RELATIONSHIP BETWEEN AMYLOID IN THE RETINA AND A BRAIN‐BASED POST‐MORTEM DIAGNOSIS OF ALZHEIMER's DISEASE Open
We have previously shown that amyloid deposits in the neural retina in human are a biomarker of Alzheimer's disease (AD) and that there is evidence that they are amyloid beta (Aβ). Here we compare the occurrence of amyloid in post-mortem h…