Laura Göschel
YOU?
Author Swipe
View article: Associations between memory, depression and wellbeing of an ageing population
Associations between memory, depression and wellbeing of an ageing population Open
Dementia is a major challenge in our aging society. Apart from its health economic impact, cognitive decline may affect the quality of life (QoL) and affective states of individuals. From a measurement perspective, it is of high importance…
View article: Macromolecule Modelling for Improved Metabolite Quantification Using Short Echo Time Brain <sup>1</sup>H‐MRS at 3 T and 7 T: The PRaMM Model
Macromolecule Modelling for Improved Metabolite Quantification Using Short Echo Time Brain <sup>1</sup>H‐MRS at 3 T and 7 T: The PRaMM Model Open
To improve reliability of metabolite quantification at both, 3 T and 7 T, we propose a novel parametrized macromolecules quantification model (PRaMM) for brain 1 H MRS, in which the ratios of macromolecule peak intensities are used as soft…
View article: Reduced plasma Aß42/40 in individuals with SCD predicts increasing plasma p‐Tau 181
Reduced plasma Aß42/40 in individuals with SCD predicts increasing plasma p‐Tau 181 Open
Background In Alzheimer’s disease (AD), the decline of plasma Aß42/40 occurs before cognitive decline, presenting a potential early screening tool. However, the factors leading to the progression of the disease, specifically the increase i…
View article: Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS
Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS Open
BACKGROUND Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)‐derived measurements in Alzheimer's disease (AD) remain unclear. METHODS In a study population ( n = 127) of healthy older adult…
View article: A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring Open
An SI traceable primary calibrator was used for the development of a reference measurement procedure for α-synuclein. A targeted proteomics workflow allowed for the SI traceable quantification of α-synuclein in cerebrospinal fluid.
View article: Can construct specification equations help us progress the biomarker‐cognition debate in dementia?
Can construct specification equations help us progress the biomarker‐cognition debate in dementia? Open
Background Currently, there are no widely accepted causal models of how common biomarkers linked to dementia present as cognitive symptoms. In the current study, we present a methodology and preliminary findings to ascertain relations betw…
View article: Associations between blood‐based biomarkers and other outcomes related to Alzheimer’s disease
Associations between blood‐based biomarkers and other outcomes related to Alzheimer’s disease Open
Background Blood‐based biomarkers (BBM) have shown promising potential in diagnosis and prognosis of patients affected by Alzheimer’s disease (AD) pathology. This observational study analyzed the cross‐sectional relation between BBMs and d…
View article: Macromolecule modelling for improved metabolite quantification using short echo time brain<sup>1</sup>H MRS at 3 T and 7 T: The PRaMM Model
Macromolecule modelling for improved metabolite quantification using short echo time brain<sup>1</sup>H MRS at 3 T and 7 T: The PRaMM Model Open
Purpose To improve reliability of metabolite quantification at both, 3 T and 7 T, we propose a novel parametrized macromolecules quantification model (PRaMM) for brain 1 H MRS, in which the ratios of macromolecule peak intensities are used…
View article: Quantitative MR Image Reconstruction Using Parameter-Specific Dictionary Learning With Adaptive Dictionary-Size and Sparsity-Level Choice
Quantitative MR Image Reconstruction Using Parameter-Specific Dictionary Learning With Adaptive Dictionary-Size and Sparsity-Level Choice Open
From a clinical perspective, the obtained T1-maps could be utilized to differentiate between healthy subjects and patients with Alzheimer's disease. From a technical perspective, the proposed unsupervised method could be employe…
View article: NeuroMET Memory Metric: Improving accuracy and comparability with crosswalks
NeuroMET Memory Metric: Improving accuracy and comparability with crosswalks Open
Background The ability to measure, track over time, and compare memory ability for people with neurodegeneration is important. However, currently, full comparability of memory test data is limited by a lack of quality assurance of memory m…
View article: Forward and Backward Recalling Sequences in Spatial and Verbal Memory Tasks: What Do We Measure?
Forward and Backward Recalling Sequences in Spatial and Verbal Memory Tasks: What Do We Measure? Open
There are different views in the literature about the number and inter-relationships of cognitive domains (such as memory and executive function) and a lack of understanding of the cognitive processes underlying these domains. In previous …
View article: Traceability and comparability through crosswalks with the NeuroMET Memory Metric
Traceability and comparability through crosswalks with the NeuroMET Memory Metric Open
View article: CBT_DST raw
CBT_DST raw Open
Raw data
View article: CBT_DST raw
CBT_DST raw Open
Raw data
View article: 7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer’s disease
7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer’s disease Open
Volumes of amygdala ROIs, as determined by 7T MRI, might contribute to objectively and non-invasively identify patients with SCD, and thus aid early diagnosis and treatment of individuals at risk to develop dementia due to AD, however asso…
View article: 7T Amygdala and Hippocampus Subfields in Volumetry-Based Associations with Memory: A 3-Year Follow-Up Study of Early Alzheimer's Disease
7T Amygdala and Hippocampus Subfields in Volumetry-Based Associations with Memory: A 3-Year Follow-Up Study of Early Alzheimer's Disease Open
View article: Metrological advancements in cognitive measurement: A worked example with the NeuroMET memory metric providing more reliability and efficiency
Metrological advancements in cognitive measurement: A worked example with the NeuroMET memory metric providing more reliability and efficiency Open
Better metrics of cognition can be formed by carefully combining selected items from legacy short-term memory tests so as to enhance coherence in item design while not jeopardizing validity. In this paper, we report on how Rasch Measuremen…
View article: NMM
NMM Open
Dataset for NeuroMET Memory Metric
View article: NMM
NMM Open
Dataset for NeuroMET Memory Metric
View article: The Role of Entropy in Construct Specification Equations (CSE) to Improve the Validity of Memory Tests: Extension to Word Lists
The Role of Entropy in Construct Specification Equations (CSE) to Improve the Validity of Memory Tests: Extension to Word Lists Open
Metrological methods for word learning list tests can be developed with an information theoretical approach extending earlier simple syntax studies. A classic Brillouin entropy expression is applied to the analysis of the Rey’s Auditory Ve…
View article: Construct specification equations: ‘Recipes’ for certified reference materials in cognitive measurement
Construct specification equations: ‘Recipes’ for certified reference materials in cognitive measurement Open
View article: Metrological references for person ability in memory tests
Metrological references for person ability in memory tests Open
View article: P3‐442: CEREBRAL GABA, RESTING‐STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER'S DISEASE
P3‐442: CEREBRAL GABA, RESTING‐STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER'S DISEASE Open
Alzheimer's disease (AD) is clinically characterized by memory decline and aberrant functional connectivity (FC) of the default mode network (Wu et al., 2011, HBM). In particular, a precise coupling between the posterior cingulate cortex (…