Laura A. Graham
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View article: Targeting Bcl-xL to eliminate chemotherapy-induced tumor dormancy and prevent breast cancer metastasis
Targeting Bcl-xL to eliminate chemotherapy-induced tumor dormancy and prevent breast cancer metastasis Open
Chemotherapy-induced tumor dormancy is a major barrier to curative cancer therapy, particularly in triple-negative breast cancer (TNBC), where dormant residual cells evade treatment and fuel late relapses. To define survival mechanisms sus…
View article: Is Gaining Housing Associated With Higher Rates of Cancer Screening Among US Veterans Experiencing Homelessness?
Is Gaining Housing Associated With Higher Rates of Cancer Screening Among US Veterans Experiencing Homelessness? Open
Veterans experiencing homelessness who gain housing have higher rates of cancer screening. This finding supports promotion of housing to improve health outcomes for homeless individuals.
View article: Bridging Physics and Machine Learning: A Signature-enhanced Hybrid Framework for Streamflow Prediction in Complex Catchments
Bridging Physics and Machine Learning: A Signature-enhanced Hybrid Framework for Streamflow Prediction in Complex Catchments Open
Accurate streamflow forecasting in both managed and natural catchments is critical for sustainable water resource management in the UK. Simulating hydrological processes such as flashy flood responses and reservoir-influenced flow dynamics…
View article: ACCURACY OF MINIMUM DATA SET FALL ASSESSMENTS IN LONG-TERM CARE RESIDENTS
ACCURACY OF MINIMUM DATA SET FALL ASSESSMENTS IN LONG-TERM CARE RESIDENTS Open
The Minimum Data Set (MDS) is commonly used to ascertain falls among long-term care residents for research and quality improvement. However, studies have shown that MDS may underreport falls compared to chart abstraction. Natural Language …
View article: ‘It can Feel Like They've Forgotten you’: Enhancing Older Adult Participation in Urban Regeneration
‘It can Feel Like They've Forgotten you’: Enhancing Older Adult Participation in Urban Regeneration Open
We present two innovative and impactful interdisciplinary participatory projects highlighting interconnected older adult meanings in relation to UK town centre spaces. We argue older people occupy paradoxical positions within urban policie…
View article: Antihypertensive Deprescribing and Cardiovascular Events Among Long-Term Care Residents
Antihypertensive Deprescribing and Cardiovascular Events Among Long-Term Care Residents Open
Importance The practice of deprescribing antihypertensive medications is common among long-term care residents, yet the effect on cardiovascular outcomes is unclear. Objective To compare the incidence of hospitalization for myocardial infa…
View article: Deprescribing of Antihypertensive Medications and Cognitive Function in Nursing Home Residents
Deprescribing of Antihypertensive Medications and Cognitive Function in Nursing Home Residents Open
Importance Antihypertensive medication deprescribing is common among nursing home residents, yet its association with cognitive decline remains uncertain. Objective To investigate the association of deprescribing antihypertensive medicatio…
View article: Health Insurance Enrollment Among US Veterans, 2010-2021
Health Insurance Enrollment Among US Veterans, 2010-2021 Open
Importance Department of Veterans Affairs (VA) health care spending has increased in the past decade, in part due to legislative changes that expanded access to VA-purchased care. Objective To understand how insurance coverage and enrollme…
View article: Charting the course: natural language processing unveils regional anesthesia procedures in clinical records – an infographic
Charting the course: natural language processing unveils regional anesthesia procedures in clinical records – an infographic Open
Documentation practices for regional anesthesia vary widely due to limited guidance, which can result in missing and inaccurate data capture. This study developed a natural language processing (NLP) algorithm to identify regional anesthesi…
View article: Antihypertensive Medication and Fracture Risk in Older Veterans Health Administration Nursing Home Residents
Antihypertensive Medication and Fracture Risk in Older Veterans Health Administration Nursing Home Residents Open
Importance Limited evidence exists on the association between initiation of antihypertensive medication and risk of fractures in older long-term nursing home residents. Objective To assess the association between antihypertensive medicatio…
View article: Mapping the Discharge Process After Surgery
Mapping the Discharge Process After Surgery Open
Importance Care transition models are structured approaches used to ensure the smooth transfer of patients between health care settings or levels of care, but none currently are tailored to the surgical patient. Tailoring care transition m…
View article: Housing Status Changes Are Associated With Cancer Outcomes Among US Veterans
Housing Status Changes Are Associated With Cancer Outcomes Among US Veterans Open
Cancer is a leading cause of death in older unhoused adults. We assessed whether being unhoused, gaining housing, or losing housing in the year after cancer diagnosis is associated with poorer survival compared with being continuously hous…
View article: Nutrition environments in early childhood education: do they align with best practice?
Nutrition environments in early childhood education: do they align with best practice? Open
Objective: To assess the comprehensiveness (scope of nutrition guidance) and strength (clarity of written language) of centre-based nutrition policies (CBNP) within early childhood education (ECE) centres. To also consider the applicabilit…
View article: Housing Status, Cancer Care, and Associated Outcomes Among US Veterans
Housing Status, Cancer Care, and Associated Outcomes Among US Veterans Open
Importance Cancer is a leading cause of death among older people experiencing homelessness. However, the association of housing status with cancer outcomes is not well described. Objective To characterize the diagnosis, treatment, surgical…
View article: ANTIHYPERTENSIVE DEPRESCRIBING AND DISABILITY IN VA NURSING HOME RESIDENTS WITH AND WITHOUT DEMENTIA
ANTIHYPERTENSIVE DEPRESCRIBING AND DISABILITY IN VA NURSING HOME RESIDENTS WITH AND WITHOUT DEMENTIA Open
Deprescribing antihypertensives is of growing interest in geriatric medicine, yet clinical trial evidence is lacking. We leveraged the Veterans Affairs (VA) electronic health data and emulated a target trial of antihypertensive deprescribi…
View article: ANTIHYPERTENSIVE DEPRESCRIBING AND COGNITIVE FUNCTION IN VA NURSING HOME RESIDENTS: A TARGET TRIAL EMULATION
ANTIHYPERTENSIVE DEPRESCRIBING AND COGNITIVE FUNCTION IN VA NURSING HOME RESIDENTS: A TARGET TRIAL EMULATION Open
Deprescribing is the practice of discontinuing or reducing medication that no longer provides benefits or causes harm. While deprescribing antihypertensives for frail elderly patients has gained interest, its impact on patient-centered out…
View article: Improving Ventilator-Associated Event Surveillance with Dynamic Device-Collected Data
Improving Ventilator-Associated Event Surveillance with Dynamic Device-Collected Data Open
Objective: To understand the feasibility of automated surveillance, we compared the results of a surveillance algorithm to identify ventilator-associated events (VAE) to the current method of manual chart review and data entry. Methods and…
View article: Association Between Self-Reported Health and Reliance on Veterans Affairs for Health Care Among Veterans Affairs Enrollees
Association Between Self-Reported Health and Reliance on Veterans Affairs for Health Care Among Veterans Affairs Enrollees Open
This cross-sectional study using survey data investigates the association between level of reliance on the Department of Veterans Affairs for health care and self-reported health by type of insurance coverage among VA enrollees.
View article: Myocardial Infarction Across COVID‐19 Pandemic Phases: Insights From the Veterans Health Affairs System
Myocardial Infarction Across COVID‐19 Pandemic Phases: Insights From the Veterans Health Affairs System Open
Background Cardiovascular procedural treatments were deferred at scale during the COVID‐19 pandemic, with unclear impact on patients presenting with non–ST‐segment–elevation myocardial infarction (NSTEMI). Methods and Results In a retrospe…
View article: Supplementary Methods from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Supplementary Methods from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
PDF file - 147K
View article: Supplementary Figure 2 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Supplementary Figure 2 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
PDF file - 235K
View article: Supplementary Methods from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Supplementary Methods from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
PDF file - 147K
View article: Supplementary Figure 1 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Supplementary Figure 1 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
PDF file - 253K
View article: Data from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Data from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
Methyl cytosine binding domain protein 2 (MBD2) has been shown to bind to and mediate repression of methylated tumor suppressor genes in cancer cells, where repatterning of CpG methylation and associated gene silencing is common. We have i…
View article: Supplementary Figure 1 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Supplementary Figure 1 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
PDF file - 253K
View article: Data from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Data from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
Methyl cytosine binding domain protein 2 (MBD2) has been shown to bind to and mediate repression of methylated tumor suppressor genes in cancer cells, where repatterning of CpG methylation and associated gene silencing is common. We have i…
View article: Supplementary Figure 2 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Supplementary Figure 2 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells Open
PDF file - 235K
View article: Association Between Preoperative Diabetes Control and Postoperative Adverse Events Among Veterans Health Administration Patients With Diabetes Who Underwent Elective Ambulatory Hernia Surgery
Association Between Preoperative Diabetes Control and Postoperative Adverse Events Among Veterans Health Administration Patients With Diabetes Who Underwent Elective Ambulatory Hernia Surgery Open
This cohort study examines the association between same-day preoperative glycemic control and postoperative adverse events among patients with diabetes undergoing ambulatory hernia surgery.