Laura J. Gray
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View article: Mapping the evidence for patient and public involvement and engagement in statistical methodology research: A scoping review protocol
Mapping the evidence for patient and public involvement and engagement in statistical methodology research: A scoping review protocol Open
Objective To identify and map the existing literature on the conduct of patient and public involvement and engagement (PPIE) for statistical methodology. Introduction PPIE refers to the consideration of patient and public perspectives into…
View article: Patient and Public Involvement (PPI) in Secondary Data Analysis: Protocol for a Targeted Review
Patient and Public Involvement (PPI) in Secondary Data Analysis: Protocol for a Targeted Review Open
Introduction Patient and public involvement (PPI) is increasingly recognised as a vital component of health research, promoting inclusivity, relevance and impact. While PPI is well‐integrated into primary research, its role in secondary da…
View article: Longitudinal associations between alcohol use, occupational stressors, and mental health among healthcare and ancillary workers in the United Kingdom during the COVID-19 pandemic (UK-REACH)
Longitudinal associations between alcohol use, occupational stressors, and mental health among healthcare and ancillary workers in the United Kingdom during the COVID-19 pandemic (UK-REACH) Open
Background The COVID-19 pandemic exacerbated exposure to trauma and demands for healthcare workers (HCWs), which are known risks for heavy alcohol use and common mental disorders (CMD). We investigated the longitudinal associations between…
View article: Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study
Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study Open
WIfI clinical stage is strongly associated with major amputation at 1-year in patients with CLTI. Given its lack of association with QoL, WIfI stages may not reflect the full severity of symptoms experienced by patients.
View article: A feasibility study evaluating the usability and acceptability of the personalised space technology exercise platform mobile application
A feasibility study evaluating the usability and acceptability of the personalised space technology exercise platform mobile application Open
The P-STEP (Personalised Space Technology Exercise Platform) app is designed to bring together tailored exercise guidance and up-to-date air quality information for individuals with long term health conditions. The app allows individuals t…
View article: Patient-reported quality of life (QoL) measurements in adults with multiple long-term conditions: A scoping review protocol
Patient-reported quality of life (QoL) measurements in adults with multiple long-term conditions: A scoping review protocol Open
Objective This scoping review will systematically map the evidence on Patient Reported Outcome Measures (PROMS) used to assess quality of life (QoL) in adults with multiple long-term conditions (MLTC) across all healthcare and community se…
View article: The effect of a six-month programme of intradialytic cycling on survival and hospitalisations in people requiring haemodialysis: 5-year follow-up of the CYCLE-HD randomised controlled trial
The effect of a six-month programme of intradialytic cycling on survival and hospitalisations in people requiring haemodialysis: 5-year follow-up of the CYCLE-HD randomised controlled trial Open
We have previously shown that a six-month programme of intradialytic cycling (IDC) improved cardiovascular structure and function, it is unclear whether these changes are associated with long-term benefits. The aim of this post-trial analy…
View article: Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings
Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings Open
Patient and Public Involvement (PPI) is well‐established in applied health research but remains under utilised in statistical methodology research due to perceived irrelevance and communication challenges. This paper summarises a one‐day w…
View article: Randomised controlled trials for improving health outcomes for people living with multiple long-term conditions: Protocol for a systematic review of methodological approaches, risk of bias and reporting quality
Randomised controlled trials for improving health outcomes for people living with multiple long-term conditions: Protocol for a systematic review of methodological approaches, risk of bias and reporting quality Open
Introduction The number of people living with multiple long-term conditions (MLTC or multimorbidity) is increasing. There have been national and international calls for more and better research in this clinical area. This systematic review…
View article: Evaluation of the usability and acceptability of the P-STEP (Personalised Space Technology Exercise Platform) ® mobile app: Feasibility study
Evaluation of the usability and acceptability of the P-STEP (Personalised Space Technology Exercise Platform) ® mobile app: Feasibility study Open
Background The P-STEP® (Personalised Space Technology Exercise Platform) app is designed to bring together tailored exercise guidance and up-to-date air quality information for patients with long term health conditions. The app allows indi…
View article: Equality, equity, diversity, and inclusion principles: how should we apply these to statistical methodology research?
Equality, equity, diversity, and inclusion principles: how should we apply these to statistical methodology research? Open
Background The aim of equality, equity, diversity, and inclusion (EDI) is to ensure fair treatment, equal opportunities, equitable outcomes, and representation. The NIHR Research Design Service (RDS) EDI toolkit ( https://www.rssleicesterr…
View article: A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi‐centre randomised control trial ( <scp>MiFoot</scp> study)
A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi‐centre randomised control trial ( <span>MiFoot</span> study) Open
Background In the United Kingdom, the prevalence of diabetes‐related foot ulcer disease (DFUD) is 6.3%, and cardiovascular disease (CVD) is the leading cause of mortality in people with DFUD. This study aims to evaluate the effectiveness o…
View article: Regional variation in non-traumatic major lower limb amputation in England: observational study of linked primary and secondary care data
Regional variation in non-traumatic major lower limb amputation in England: observational study of linked primary and secondary care data Open
Background Peripheral artery disease and diabetes are the main primary risk factors for non-traumatic major lower limb amputation. Regional variation in incidence of major lower limb amputation has yet to be fully described in terms of the…
View article: Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT
Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT Open
Background Self-management education and support programmes help people with type 2 diabetes to manage their diabetes better. However, most people do not attend these programmes. Objective Increase type 2 diabetes self-management programme…
View article: Defining within-host SARS-CoV-2 RNA viral load kinetics during acute COVID-19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta-analysis
Defining within-host SARS-CoV-2 RNA viral load kinetics during acute COVID-19 infection within different respiratory compartments and their respective associations with host infectiousness: a protocol for a systematic review and meta-analysis Open
Introduction Understanding how RNA viral load changes (viral load kinetics) during acute infection in SARS-CoV-2 can help to identify when and which patients are most infectious. We seek to summarise existing data on the longitudinal RNA v…
View article: Corrigendum to “Persistent hesitancy for SARS-CoV-2 vaccines among healthcare workers in the United Kingdom: analysis of longitudinal data from the UK-REACH cohort study” [The Lancet Regional Health – Europe, Volume 13, February 2022, 100299]
Corrigendum to “Persistent hesitancy for SARS-CoV-2 vaccines among healthcare workers in the United Kingdom: analysis of longitudinal data from the UK-REACH cohort study” [The Lancet Regional Health – Europe, Volume 13, February 2022, 100299] Open
[This corrects the article DOI: 10.1016/j.lanepe.2021.100299.].
View article: Physical activity and sedentary behaviour interventions for people living with both frailty and multiple long-term conditions and their informal carers: a scoping review and stakeholder consultation
Physical activity and sedentary behaviour interventions for people living with both frailty and multiple long-term conditions and their informal carers: a scoping review and stakeholder consultation Open
Introduction This scoping review mapped evidence on physical activity (including structured exercise) and sedentary behaviour interventions (interventions to reduce sedentary behaviour) in people living with both frailty and multiple long-…
View article: Streamlined Clinical Management Pathways May Reduce Major Amputations in Patients with Chronic Limb Threatening Ischaemia: A Prospective Cohort Study with Historical Controls
Streamlined Clinical Management Pathways May Reduce Major Amputations in Patients with Chronic Limb Threatening Ischaemia: A Prospective Cohort Study with Historical Controls Open
An encouraging reduction in major amputation incidence was observed after improvements to CLTI management pathways, but residual confounding is likely. The generalisability of these results is uncertain.
View article: 2214 Using poisons Centre data to identify potential safety risks associated with the use of monitored dosage systems.
2214 Using poisons Centre data to identify potential safety risks associated with the use of monitored dosage systems. Open
Introduction Monitored dosage systems (MDS) encompass a wide range of devices to help management of medication. This research uses poison centre data to explore risks associated with their use. Method A search of accidental overdose enquir…
View article: Impact of physical activity on surrogate markers of cardiovascular disease in the haemodialysis population
Impact of physical activity on surrogate markers of cardiovascular disease in the haemodialysis population Open
Background The haemodialysis (HD) population is sedentary, with substantial cardiovascular disease risk. In the general population, small increases in daily step count associate with significant reductions in cardiovascular mortality. This…
View article: Inclusion of racial and ethnic groups in clinical trials for COVID-19 and post-acute COVID-19 syndrome: An analysis of studies registered on ClinicalTrials.gov
Inclusion of racial and ethnic groups in clinical trials for COVID-19 and post-acute COVID-19 syndrome: An analysis of studies registered on ClinicalTrials.gov Open
We read with interest the study by Juan and colleagues, who found in a network systematic review and meta-analysis of nine observational studies, that early use of oral antiviral drugs could protect against developing post-acute COVID-19 s…
View article: Discrimination, disadvantage and disempowerment during COVID-19: a qualitative intrasectional analysis of the lived experiences of an ethnically diverse healthcare workforce in the United Kingdom
Discrimination, disadvantage and disempowerment during COVID-19: a qualitative intrasectional analysis of the lived experiences of an ethnically diverse healthcare workforce in the United Kingdom Open
Background Healthcare workers (HCWs) in the United Kingdom (UK) have faced many challenges during the COVID-19 pandemic, some of these arising out of their social positions. Existing literature explicating these challenges (e.g., lack of a…
View article: Single-centre prospective cohort study investigating the associations and one-year trends of frailty, cognition, disability and quality of life pre- and post-intervention for chronic limb-threatening ischaemia
Single-centre prospective cohort study investigating the associations and one-year trends of frailty, cognition, disability and quality of life pre- and post-intervention for chronic limb-threatening ischaemia Open
Background: Half of people with chronic limb-threatening ischaemia (CLTI) have frailty. This study aimed to describe the associations of frailty with cognition, disability and quality of life (QoL) among CLTI patients over 1 year following…
View article: Uptake of self-management education programmes for people with type 2 diabetes in primary care through the embedding package: a cluster randomised control trial and ethnographic study
Uptake of self-management education programmes for people with type 2 diabetes in primary care through the embedding package: a cluster randomised control trial and ethnographic study Open
Background Self-management education programmes are cost-effective in helping people with type 2 diabetes manage their diabetes, but referral and attendance rates are low. This study reports on the effectiveness of the Embedding Package, a…
View article: Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study
Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study Open
Background Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We …