Laura J. Hewson
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View article: Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome
Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome Open
Mucopolysaccharidosis (MPS) types III A and C are inherited neurodegenerative disorders resulting from the lack of a specific enzyme involved in heparan sulfate (HS) catabolism, leading to the accumulation of partially-degraded HS fragment…
View article: <scp><i>Drosophila melanogaster</i></scp>models of<scp>MPS IIIC</scp>(<scp><i>Hgsnat</i></scp>‐deficiency) highlight the role of glia in disease presentation
<span><i>Drosophila melanogaster</i></span>models of<span>MPS IIIC</span>(<span><i>Hgsnat</i></span>‐deficiency) highlight the role of glia in disease presentation Open
Sanfilippo syndrome (Mucopolysaccharidosis type III or MPS III) is a recessively inherited neurodegenerative lysosomal storage disorder. Mutations in genes encoding enzymes in the heparan sulphate degradation pathway lead to the accumulati…
View article: Substrate reduction therapy in a<i>Drosophila melanogaster</i>model of Sanfilippo syndrome
Substrate reduction therapy in a<i>Drosophila melanogaster</i>model of Sanfilippo syndrome Open
Sanfilippo syndrome, or mucopolysaccharidosis (MPS) types A, B, C or D, are neurodegenerative lysosomal storage disorders resulting from the lack of a specific enzyme involved in heparan sulfate (HS) catabolism. Several treatments are unde…