Laura J. Suggs
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View article: Modulating Lipid-Polymer Nanoparticles’ Physicochemical Properties to Alter Macrophage Uptake
Modulating Lipid-Polymer Nanoparticles’ Physicochemical Properties to Alter Macrophage Uptake Open
Macrophage uptake of nanoparticles is highly dependent on the physicochemical characteristics of those nanoparticles. Here, we have created a collection of lipid-polymer nanoparticles (LPNPs) varying in size, stiffness, and lipid makeup to…
View article: Scientific Skill Acquisition and Identity of Visiting Scholars in a Research Experience for Undergraduates (REU) Site
Scientific Skill Acquisition and Identity of Visiting Scholars in a Research Experience for Undergraduates (REU) Site Open
This paper describes a preliminary analysis of a summer Research Experience for Undergraduates (REU) Site sponsored by the biomedical engineering department at a large public institution in the southwest United States.Data were compiled fr…
View article: Coordinating Summer Undergraduate Research Programs for Expanding Diversity and Impact: Opportunities and Challenges
Coordinating Summer Undergraduate Research Programs for Expanding Diversity and Impact: Opportunities and Challenges Open
Affiliated Scholars were supported by a variety of other funding mechanisms with a variety of research areas.By grouping these scholars into the CUReS structure with a shared scientific theme of engineering approaches to cancer research, r…
View article: Something Old, Something New: Lessons Learned from Pivoting an REU Site during the COVID Pandemic
Something Old, Something New: Lessons Learned from Pivoting an REU Site during the COVID Pandemic Open
Due to the safety risks and potential for program disruptions posed by the on-going COVID pandemic, our REU Site transitioned to a fully virtual offering for summer 2021. In this paper, we share our experiences in offering our REU Site onl…
View article: Oxidative degradation of sequence-defined peptoid oligomers
Oxidative degradation of sequence-defined peptoid oligomers Open
Adaptable degradative responses to multiple biological stimuli are of great importance for biorecognition. Here, enzymatic and ROS degradability are tuned by monomer identity and sequence in a series of sequence-defined oligomers.
View article: Implementing Redesign in the BME Senior Capstone Experience
Implementing Redesign in the BME Senior Capstone Experience Open
and the Central American Medical Outreach (CAMO, a non-profit).Our design sequence differs from ME in a couple of notable ways: first, the two semester sequence is coupled and must be taken sequentially and second, the externally sponsored…
View article: Laser nanobubbles induce immunogenic cell death in breast cancer
Laser nanobubbles induce immunogenic cell death in breast cancer Open
Laser nanobubbles induce dendritic cell activation in breast cancer cells.
View article: Laser nanobubbles induce immunogenic cell death in breast cancer
Laser nanobubbles induce immunogenic cell death in breast cancer Open
Recent advances in immunotherapy have highlighted a need for therapeutics that initiate immunogenic cell death in tumors to stimulate the body’s immune response to cancer. This study examines whether laser-generated bubbles surrounding nan…
View article: Poly-<scp>d</scp>-lysine coated nanoparticles to identify pro-inflammatory macrophages
Poly-<span>d</span>-lysine coated nanoparticles to identify pro-inflammatory macrophages Open
Identifying pro-inflammatory macrophages (M1) is of immense importance to diagnose, monitor, and treat various pathologies. Here, we present a poly-D-lysine coated nanoparticle for real-time fluorescent labeling of M1 macrophages.
View article: Assessing the range of enzymatic and oxidative tunability for biosensor design
Assessing the range of enzymatic and oxidative tunability for biosensor design Open
This review aims to inspire novel biosensor design by addressing materials chemistries through the lense of enzymatic and oxidative susceptibility in the spectra of inflammatory disease biomarkers.
View article: A Visible Light-Cross-Linkable, Fibrin–Gelatin-Based Bioprinted Construct with Human Cardiomyocytes and Fibroblasts
A Visible Light-Cross-Linkable, Fibrin–Gelatin-Based Bioprinted Construct with Human Cardiomyocytes and Fibroblasts Open
In this study, fibrin was added to a photo-polymerizable gelatin-based bioink mixture to fabricate cardiac cell-laden constructs seeded with human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) or CM cell lines with cardiac …
View article: <i>In Vivo</i> Photoacoustic Tracking of Mesenchymal Stem Cell Viability
<i>In Vivo</i> Photoacoustic Tracking of Mesenchymal Stem Cell Viability Open
Adult stem cell therapy has demonstrated improved outcomes for treating cardiovascular diseases in preclinical trials. The development of imaging tools may increase our understanding of the mechanisms of stem cell therapy, and a variety of…
View article: Coordinating Summer Undergraduate Research Programs for Expanding Diversity and Impact: Opportunities and Challenges
Coordinating Summer Undergraduate Research Programs for Expanding Diversity and Impact: Opportunities and Challenges Open
During summers 2015-2017, we operated a National Science Foundation (NSF) funded Research Experiences for Undergraduates (REU) Site, “Biomedical Engineering Community of Undergraduate Research Scholars for Cancer” (BME CUReS Cancer) at The…
View article: Phenotypic Basis for Matrix Stiffness-Dependent Chemoresistance of Breast Cancer Cells to Doxorubicin
Phenotypic Basis for Matrix Stiffness-Dependent Chemoresistance of Breast Cancer Cells to Doxorubicin Open
The persistence of drug resistant cell populations following chemotherapeutic treatment is a significant challenge in the clinical management of cancer. Resistant subpopulations arise via both cell intrinsic and extrinsic mechanisms. Extri…
View article: A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures
A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures Open
3D bioprinting holds great promise in the field of regenerative medicine as it can create complex structures in a layer-by-layer manner using cell-laden bioinks, making it possible to imitate native tissues. Current bioinks lack both high …
View article: A Comparative Study of a 3D Bioprinted Gelatin-Based <em>Lattice</em> and <em>Rectangular-Sheet </em>Structures
A Comparative Study of a 3D Bioprinted Gelatin-Based <em>Lattice</em> and <em>Rectangular-Sheet </em>Structures Open
3D bioprinting holds great promise in the field of regenerative medicine as it can create complex structures in a layer-by-layer manner using cell-laden bioinks, making it possible to imitate native tissues. Current bioinks lack both the h…
View article: Board # 155 : Developing Science Communication Skills as a Part of a Summer Research Experiences for Undergraduates (REU) Program
Board # 155 : Developing Science Communication Skills as a Part of a Summer Research Experiences for Undergraduates (REU) Program Open
The ability to communicate effectively is one of the most important skills for engineering students to develop during their undergraduate education[1]. Undergraduate engineering programs across the country are developing their students’ co…
View article: The applicability of furfuryl‐gelatin as a novel bioink for tissue engineering applications
The applicability of furfuryl‐gelatin as a novel bioink for tissue engineering applications Open
Three‐dimensional bioprinting is an innovative technique in tissue engineering, to create layer‐by‐layer structures, required for mimicking body tissues. However, synthetic bioinks do not generally possess high printability and biocompatib…
View article: Design and Evaluation of Short Self-Assembling Depsipeptides as Bioactive and Biodegradable Hydrogels
Design and Evaluation of Short Self-Assembling Depsipeptides as Bioactive and Biodegradable Hydrogels Open
Described herein is the design of a cell-adherent and degradable hydrogel. Our goal was to create a self-assembling, backbone ester-containing analogue of the cell adhesion motif, arginine-glycine-aspartic acid (RGD). Two depsipeptides con…
View article: Therapeutic Potential of Adipose-Derived Stem Cells and Macrophages for Ischemic Skeletal Muscle Repair
Therapeutic Potential of Adipose-Derived Stem Cells and Macrophages for Ischemic Skeletal Muscle Repair Open
Combined MPs/ASCs cell therapy is a promising approach to restore muscle function and stimulate local angiogenesis in the ischemic limb.
View article: Electrospun poly(N-isopropyl acrylamide)/poly(caprolactone) fibers for the generation of anisotropic cell sheets
Electrospun poly(N-isopropyl acrylamide)/poly(caprolactone) fibers for the generation of anisotropic cell sheets Open
Cell alignment in muscle, nervous tissue, and cartilage is requisite for proper tissue function; however, cell sheeting techniques using the thermosensitive polymer poly(N-isopropyl acrylamide) can only produce anisotropic cell sheets with…