Laura K. Herzog
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View article: Cover Feature: Visible‐Light‐Switchable Molecular Glues for Reversible Control of Protein Function (Chem. Eur. J. 15/2025)
Cover Feature: Visible‐Light‐Switchable Molecular Glues for Reversible Control of Protein Function (Chem. Eur. J. 15/2025) Open
View article: Visible‐Light‐Switchable Molecular Glues for Reversible Control of Protein Function
Visible‐Light‐Switchable Molecular Glues for Reversible Control of Protein Function Open
Chemically induced dimerization/proximity (CID/CIP) systems controlled by chemical dimerizers (also known as molecular glues) provide valuable means for understanding and manipulating complex, dynamic biological systems. In this study, we …
View article: ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases
ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases Open
SUMMARY The endosomal sorting complex required for transport (ESCRT) machinery plays an essential role in the sealing of endolysosomal membranes damaged by pathogenic, chemical or physical stress. How membrane damage is sensed by the cell …
View article: A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation Open
The endosomal sorting complex required for transport (ESCRT) machinery constitutes multisubunit protein complexes that play an essential role in membrane remodeling and trafficking. ESCRTs regulate a wide array of cellular processes, inclu…
View article: Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes
Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes Open
The Endosomal Sorting Complex Required for Transport (ESCRT) machinery constitutes a multisubunit protein complex that plays an essential role in membrane remodeling and trafficking. ESCRTs regulate a wide array of cellular processes, enco…
View article: An ATG12‐ATG5‐TECPR1 E3‐like complex regulates unconventional LC3 lipidation at damaged lysosomes
An ATG12‐ATG5‐TECPR1 E3‐like complex regulates unconventional LC3 lipidation at damaged lysosomes Open
Lysosomal membrane damage represents a threat to cell viability. As such, cells have evolved sophisticated mechanisms to maintain lysosomal integrity. Small membrane lesions are detected and repaired by the endosomal sorting complex requir…
View article: Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy Open
The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of aberrant proteins, th…
View article: MacroGreen, a simple tool for detection of ADP-ribosylated proteins
MacroGreen, a simple tool for detection of ADP-ribosylated proteins Open
García Saura et al. report a new tool, MacroGreen, to detect ADP-ribosylation by GFP fluorescence in a microplate reader, or in cells by microscopy. With superior affinity and reduced ADP-ribosyl hydrolase activity, MacroGreen is an easy t…
View article: Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair
Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair Open
DNA damage-induced SUMOylation serves as a signal for two antagonizing proteins that both stimulate repair of DNA double-strand breaks (DSBs). Here, we demonstrate that the SUMO-dependent recruitment of the deubiquitylating enzyme ataxin-3…
View article: K63-linked ubiquitylation induces global sequestration of mitochondria
K63-linked ubiquitylation induces global sequestration of mitochondria Open
Even though K63-linked polyubiquitin chains do not target proteins for proteasomal degradation, they play nevertheless a complementary protective role in maintaining protein homeostasis by directing malfunctioning proteins and organelles t…
View article: The price of longevity
The price of longevity Open
View article: The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy
The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy Open
The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, …
View article: Ataxin‐3 consolidates the <scp>MDC</scp> 1‐dependent <scp>DNA</scp> double‐strand break response by counteracting the <scp>SUMO</scp> ‐targeted ubiquitin ligase <scp>RNF</scp> 4
Ataxin‐3 consolidates the <span>MDC</span> 1‐dependent <span>DNA</span> double‐strand break response by counteracting the <span>SUMO</span> ‐targeted ubiquitin ligase <span>RNF</span> 4 Open