Laura K. Shinehouse
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View article: CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy
CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy Open
Background Relapse of B-cell acute lymphoblastic leukemia (B-ALL) with CD19-antigen loss after CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has a dismal prognosis. Novel immunotherapeutic strategies for this patient populat…
View article: Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis Open
Importance Studies using human postmortem tissue and imaging with positron emission tomography (PET) support a low hippocampal availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in psychotic conditions, particularly in schi…
View article: Imaging Brain Injury in Former National Football League Players
Imaging Brain Injury in Former National Football League Players Open
Importance Pilot studies that involved early imaging of the 18 kDa translocator protein (TSPO) using positron emission tomography (PET) indicated high levels of TSPO in the brains of active or former National Football League (NFL) players.…
View article: PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC
PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC Open
Purpose: We report findings from the first-in-human study of [ 11 C]MDTC, a radiotracer developed to image the cannabinoid receptor type 2 (CB2R) with positron emission tomography (PET). Methods: Ten healthy adults were imaged according to…
View article: High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with <sup>18</sup>F-DCFPyL
High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with <sup>18</sup>F-DCFPyL Open
Objectives. In patients with prostate cancer (PC) receiving prostate-specific membrane antigen- (PSMA-) targeted radioligand therapy (RLT), higher baseline standardized uptake values (SUVs) are linked to improved outcome. Thus, readers dec…
View article: First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET
First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET Open
View article: High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using <sup>18</sup>F-ASEM PET
High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using <sup>18</sup>F-ASEM PET Open
Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer’s disease. (18)F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-(18)F-fluorodibenzo[b,d]thiophene 5,5-…