Laura Kracht
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View article: Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage Open
Organoid models have significantly enhanced our understanding of adult stem cell function, however, uncovering regulatory mechanisms governing rare and often quiescent stem cells in glandular organs remains challenging. Here, we employ an …
View article: Increased TNF Superfamily Members in Neuroinflammatory Schizophrenia and Bipolar Disorder Midbrains
Increased TNF Superfamily Members in Neuroinflammatory Schizophrenia and Bipolar Disorder Midbrains Open
View article: Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor cells
Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor cells Open
Organoid models have advanced our understanding of adult stem/progenitor cell dynamics and function. However, uncovering the regulatory mechanisms of scarce and often quiescent stem cells in organs like the salivary glands remains challeng…
View article: Schizophrenia-associated changes in neuronal subpopulations in the human midbrain
Schizophrenia-associated changes in neuronal subpopulations in the human midbrain Open
Dysfunctional GABAergic and dopaminergic neurons are thought to exist in the ventral midbrain of patients with schizophrenia, yet transcriptional changes underpinning these abnormalities have not yet been localized to specific neuronal sub…
View article: Single-nucleus RNA sequencing of the midbrain blood-brain barrier cells in schizophrenia
Single-nucleus RNA sequencing of the midbrain blood-brain barrier cells in schizophrenia Open
Background: The increased inflammatory state observed in schizophrenia post-mortem brain and midbrain tissue [1-5] may have detrimental consequences on the brain vasculature of patients with schizophrenia. On the other hand, intrinsic alte…
View article: Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels
Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels Open
Human salivary gland organoids have opened tremendous possibilities for regenerative medicine in patients undergoing radiotherapy for the treatment of head and neck cancer. However, their clinical translation is greatly limited by the curr…
View article: Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions Open
View article: Patient-derived parathyroid organoids as a tracer and drug-screening application model
Patient-derived parathyroid organoids as a tracer and drug-screening application model Open
View article: Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes
Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes Open
View article: Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions Open
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, …
View article: Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions Open
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, …
View article: Single-nucleus RNA sequencing of the midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes
Single-nucleus RNA sequencing of the midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes Open
The midbrain is an important brain region for the study of schizophrenia in view of its reported dopamine pathophysiology and observed neuroimmune changes associated with schizophrenia. Besides the dopaminergic system, the midbrain contain…
View article: Epigenetic regulation of innate immune memory in microglia
Epigenetic regulation of innate immune memory in microglia Open
View article: Patient-derived parathyroid organoids as tracer and drug-screening application model
Patient-derived parathyroid organoids as tracer and drug-screening application model Open
Parathyroid diseases are characterized by dysregulation of calcium homeostasis and alterations in parathyroid hormone (PTH) excretion. The understanding of parathyroid hyperplastic growth and the development of parathyroid-targeted treatme…
View article: Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter Open
View article: Additional file 12 of Epigenetic regulation of innate immune memory in microglia
Additional file 12 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 12: TFBS of differential ATAC peaks in microglia of WT-PBS versus KO-PBS and WT-LPS versus KO-LPS mice and classification of TFs based on correlation of TFBS peaks with TF target gene expression (related to Figs. 4D, 4E, 5C…
View article: Additional file 14 of Epigenetic regulation of innate immune memory in microglia
Additional file 14 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 14: GO terms associated with genes uniquely or overlappingly enriched in acute, tolerized, primed and trained microglia (related to Fig. 5B).
View article: Additional file 13 of Epigenetic regulation of innate immune memory in microglia
Additional file 13 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 13: Lists of genes uniquely or overlappingly enriched in acute, tolerized, primed and trained microglia (related to Fig. 5A).
View article: Additional file 10 of Epigenetic regulation of innate immune memory in microglia
Additional file 10 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 10: TFBS of differential ATAC peaks in microglia of PP versus PL, LL versus PL and LP versus LL mice and classification of TFs based on correlation of TFBS peaks with TF target gene expression (related to Figs. 3D, 3E, 3F, …
View article: Additional file 9 of Epigenetic regulation of innate immune memory in microglia
Additional file 9 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 9: Annotated differential ATAC, H3K4me3 and H3K27ac peaks in microglia of PL versus PP, PL versus LL and LL versus LP mice (related to Fig. 3A, 3B, 3C).
View article: Additional file 6 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Additional file 6 of Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter Open
Additional file 6: Table S1: Donor and sample information. Table S2: Differential gene expression analysis total tissue bulk data. Table S3: WGCNA modules. Table S4: Differential gene expression analysis between clusters (human single cell…
View article: Additional file 5 of Epigenetic regulation of innate immune memory in microglia
Additional file 5 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 5: Count table and differentially expressed genes for all comparisons in the tolerance mouse model (related to Figs. 1 and 3).
View article: Additional file 7 of Epigenetic regulation of innate immune memory in microglia
Additional file 7 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 7: Genes and associated gene ontology terms for each cluster identified in the tolerance model (related to Figs. 2 and S3).
View article: Additional file 11 of Epigenetic regulation of innate immune memory in microglia
Additional file 11 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 11: Annotated differential ATAC, H3K4me1, H3K4me3, H3K27ac and H3K27ac peaks in microglia of KO-PBS versus WT-PBS, KO-LPS versus WT-LPS, WT-LPS versus WT-PBS and KO-LPS versus WT-PBS mice (related to Fig. 4A, 4B).
View article: Additional file 8 of Epigenetic regulation of innate immune memory in microglia
Additional file 8 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 8: Genes and associated gene ontology terms for each cluster identified in the priming mouse model (related to Figs. 2 and S3).
View article: Additional file 6 of Epigenetic regulation of innate immune memory in microglia
Additional file 6 of Epigenetic regulation of innate immune memory in microglia Open
Additional file 6: Count table and differentially expressed genes for all comparisons in the primed mouse model (related to Figs. 1 and 4).
View article: The kaleidoscope of microglia phenotypes
The kaleidoscope of microglia phenotypes Open
Microglia are relatively long-lived and self-sustainable macrophages of the central nervous system (CNS). Microglia functions exceed the non-specific defense functions classically associated with the innate immune system and their main fun…
View article: Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis
Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis Open
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point …
View article: Epigenetic regulation of innate immune memory in microglia
Epigenetic regulation of innate immune memory in microglia Open
Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative slow turno…
View article: Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue
Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue Open
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation i…