Laura D. Kramer
YOU?
Author Swipe
View article: Proceedings from the Fourth Mesoamerican Symposium “Dr. Roberto Navarro López” on Emerging Zoonotic Disease and Arboviruses: Commenting Insights and Research Findings
Proceedings from the Fourth Mesoamerican Symposium “Dr. Roberto Navarro López” on Emerging Zoonotic Disease and Arboviruses: Commenting Insights and Research Findings Open
Zoonotic pathogens such as arboviruses, arenaviruses, filoviruses, coronaviruses, highly pathogenic Avian Influenza A (H5N1) viruses, vesiculoviruses, and many others are emerging and reemerging worldwide, jeopardizing global veterinary an…
SARS-CoV-2 lineage-dependent temporal phylogenetic distribution and viral load in immunocompromised and immunocompetent individuals Open
Immunocompromised patients have lower viral loads, probably due to their later diagnosis compared to NICs and oncology patients, who have better access to on-site SARS-CoV-2 testing and follow-up. In addition, mutational profiles differ be…
Modelling the temperature dependent extrinsic incubation period of West Nile Virus using Bayesian time delay models Open
West Nile Virus (WNV) is a mosquito-borne pathogen that primarily infects birds. Infections can spillover to humans and cause a spectrum of clinical symptoms, including WNV neuroinvasive disease. The extrinsic incubation period (EIP) is th…
Higher Levels of SARS-CoV-2 Genetic Variation in Immunocompromised Patients: A Retrospective Case-Control Study Open
Background A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection lasts longer in immunocompromised hosts than in immunocompetent patients. Prolonged infection is associated with a higher probability of selection for nove…
View article: A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures
A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures Open
Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide …
View article: Surveillance and Genetic Analysis of Jamestown Canyon Virus in New York State: 2001–2022
Surveillance and Genetic Analysis of Jamestown Canyon Virus in New York State: 2001–2022 Open
Jamestown Canyon virus (JCV) (Peribunyavirdae; Orthobunyavirus ) is a mosquito-borne pathogen endemic to North America. The genome is composed of three segmented negative-sense RNA fragments designated as small, medium, and large. Jamestow…
The impact of the international code of marketing of breast-milk substitutes in Ghana and Tanzania Open
Background Measures that promote and protect breastfeeding have a major impact on child survival rates, as it was estimated that increasing breastfeeding rates can reduce child mortality by 13% in Africa. The International Code of Marketin…
View article: Which severe COVID-19 patients could benefit from high dose dexamethasone? A Bayesian post-hoc reanalysis of the COVIDICUS randomized clinical trial
Which severe COVID-19 patients could benefit from high dose dexamethasone? A Bayesian post-hoc reanalysis of the COVIDICUS randomized clinical trial Open
Background The respective benefits of high and low doses of dexamethasone (DXM) in patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) and acute respiratory failure (ARF) are controversial, with two large triple-blind…
View article: Cefiderocol Treatment for Severe Infections due to Difficult-to-Treat-Resistant Non-Fermentative Gram-Negative Bacilli in ICU Patients: A Case Series and Narrative Literature Review
Cefiderocol Treatment for Severe Infections due to Difficult-to-Treat-Resistant Non-Fermentative Gram-Negative Bacilli in ICU Patients: A Case Series and Narrative Literature Review Open
Cefiderocol (FDC) is a siderophore cephalosporin now recognized as a new weapon in the treatment of difficult-to-treat-resistant (DTR) Gram-negative pathogens, including carbapenemase-producing enterobacterales and non-fermentative Gram-ne…
Phylogeographic reconstruction of the emergence and spread of Powassan virus in the northeastern United States Open
Powassan virus is an emerging tick-borne virus of concern for public health, but very little is known about its transmission patterns and ecology. Here, we expanded the genomic dataset by sequencing 279 Powassan viruses isolated from Ixode…
Dynamics of Eastern equine encephalitis virus during the 2019 outbreak in the Northeast United States Open
Eastern equine encephalitis virus (EEEV) causes a rare but severe disease in horses and humans, and is maintained in an enzootic transmission cycle between songbirds and Culiseta melanura mosquitoes. In 2019, the largest EEEV outbreak in t…
Recommendations for Laboratory Detection and Diagnosis of Arbovirus Infections in the Region of the Americas Open
Human infection with arboviruses, such as dengue, yellow fever, chikungunya and zika, occurs through the bite of blood-sucking arthropods (mosquitos, ticks and midges, among others). There are more than 100 types of arboviruses and the inf…
Bourbon Virus Transmission, New York, USA Open
In July 2019, Bourbon virus RNA was detected in an Amblyomma americanum tick removed from a resident of Long Island, New York, USA. Tick infection and white-tailed deer (Odocoileus virginianus) serosurvey results demonstrate active transmi…
History of Arbovirology: Memories from the Field Open
This volume describes region-specific and virus family-specific perspectives, as well as recollections of early molecular advances and pathogenesis studies
Identification and characterization of novel lineage 1 Powassan virus strains in New York State Open
Powassan virus (POWV, family Flaviviridae) is a reemerging tick-borne virus endemic in North America and Russia. In 1997, a POWV-like agent was isolated from Ixodes scapularis in New England and determined to be genetically distinct from t…
Bourbon virus transmission, New York State Open
In July 2019, Bourbon virus RNA was detected in an Amblyomma americanum tick removed from a resident of Long Island, New York. Tick infection and white-tailed deer ( Odocoileus virginianus ) serosurvey results demonstrate active transmissi…
Phylogeographic reconstruction of the emergence and spread of Powassan virus in the northeastern United States Open
Powassan virus is an emerging tick-borne virus of concern for public health, but very little is known about its transmission patterns and ecology. Here, we expanded the genomic dataset by sequencing 279 Powassan viruses isolated from Ixode…
View article: Dual Monoclonal Antibodies on Sars-Cov-2 Alpha and Delta Variants: Clinical and Virological Efficacy
Dual Monoclonal Antibodies on Sars-Cov-2 Alpha and Delta Variants: Clinical and Virological Efficacy Open
Monoclonal antibody bitherapies (MAbs) are commonly prescribed to treat severe SARS-CoV-2-positive patients, and the rapid growth of resistance mutation emergence is alarming globally. To explore this issue, we conducted both clinical and …
View article: Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction
Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction Open
Background: West Nile virus (WNV) is the leading cause of mosquito-borne illness in the continental United States. WNV occurrence has high spatiotemporal variation and current approaches for targeted control of the virus are limited, makin…
View article: Breakthrough infections after post-exposure vaccination against Monkeypox
Breakthrough infections after post-exposure vaccination against Monkeypox Open
Background A third-generation smallpox vaccine was recommended in France for individuals who had a high-risk contact with a PCR-confirmed Monkeypox patient. We aimed to describe the outcomes of high-risk contacts receiving third-generation…
Vector competence of Anopheles quadrimaculatus and Aedes albopictus for genetically distinct Jamestown Canyon virus strains circulating in the Northeast United States Open
Background Jamestown Canyon virus (JCV; Peribunyaviridae, Orthobunyavirus) is a mosquito-borne pathogen belonging to the California serogroup. The virus is endemic in North America and increasingly recognized as a public health concern. In…