Laura Leoni
YOU?
Author Swipe
View article: NCOG-26. <i>IDH</i> -mutant gliomas treated with vorasidenib: early seizure control correlates with [18F]-DOPA PET response and D-2-hydroxyglutarate plasma reduction
NCOG-26. <i>IDH</i> -mutant gliomas treated with vorasidenib: early seizure control correlates with [18F]-DOPA PET response and D-2-hydroxyglutarate plasma reduction Open
BACKGROUND Given the role of IDH mutations and D-2-hydroxyglutarate (D2HG) in epileptogenesis, the impact of IDH inhibitors on seizure control is of interest. This prospective study assessed patterns and timing of seizure response in patie…
View article: Long term anticoagulation for Catheter-Related deep vein thrombosis of the upper extremities in women with cancer: retrospective analysis of effectiveness and safety outcomes
Long term anticoagulation for Catheter-Related deep vein thrombosis of the upper extremities in women with cancer: retrospective analysis of effectiveness and safety outcomes Open
Catheter-related upper extremity deep vein thrombosis (CRT-UEDVT) is a possible complication in patients with cancer carrying a central venous catheter. Anticoagulation is the primary treatment, but optimal duration is unclear. This study …
View article: P18 - A new LC-MS/MS method for the determination of serum cortisol, cortisone, and dexamethasone: utility in the interpretation of the low-dose dexamethasone suppression test
P18 - A new LC-MS/MS method for the determination of serum cortisol, cortisone, and dexamethasone: utility in the interpretation of the low-dose dexamethasone suppression test Open
Introduction The low-dose dexamethasone suppression test (DST) is used for diagnosis of hypercortisolism and it can be influenced by dexamethasone (DEX) bioavailability. Purpose To apply a new LC-MS/MS method for the quantification of cort…
View article: Dietary Strategies to Modulate Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Dietary Strategies to Modulate Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Open
Gut microbiota has become an area of increasing interest for its potential role in metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated steatohepatitis (MASH)—now rec…
View article: COMPARATIVE ANALYSIS OF DIFFERENT PHENOTYPES IN CARDIOGENIC SHOCK: A REAL–WORLD, SINGLE–CENTER EXPERIENCE
COMPARATIVE ANALYSIS OF DIFFERENT PHENOTYPES IN CARDIOGENIC SHOCK: A REAL–WORLD, SINGLE–CENTER EXPERIENCE Open
Background Cardiogenic shock (CS) is a clinical syndrome defined by tissue hypoperfusion due to low cardiac output. It is characterized by extreme heterogeneity in etiologies, severity, and underlying pathophysiology. Phenotypes in CS popu…
View article: Low high-density lipoprotein cholesterol, but not high low-density lipoprotein cholesterol, associates with systemic metabolic alterations
Low high-density lipoprotein cholesterol, but not high low-density lipoprotein cholesterol, associates with systemic metabolic alterations Open
Aim: Dyslipidemia encompasses various forms of lipid abnormalities and represents a central component of metabolic syndrome. The relationship between dyslipidemia subtypes and broader metabolic profiles is poorly characterized in modern po…
View article: Determination of human urinary cortisol, cortisone and relative phase II metabolites by dilute-and-shoot LC-MS/MS analysis: an application to adrenal disease
Determination of human urinary cortisol, cortisone and relative phase II metabolites by dilute-and-shoot LC-MS/MS analysis: an application to adrenal disease Open
The developed and validated dilute-and-shoot LC-MS/MS method demonstrated satisfactory performance, offering a faster, cost-effective solution for adrenal hormone analysis in clinical settings. This research also provided insights into adr…
View article: Balancing act: LDL-cholesterol control through plant-based vegan and Mediterranean diets
Balancing act: LDL-cholesterol control through plant-based vegan and Mediterranean diets Open
View article: RANK–RANKL–OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives
RANK–RANKL–OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives Open
Metabolic dysfunction-associated steatotic liver disease (MASLD)—and its worse form, metabolic-associated steatohepatitis (MASH), characterised by inflammation and liver damage—corresponds to the liver’s involvement in metabolic syndrome, …
View article: Rapid UHPLC–MS/MS measurement of pregnanediol 3‐glucuronide in spot urine samples for detecting ovulation
Rapid UHPLC–MS/MS measurement of pregnanediol 3‐glucuronide in spot urine samples for detecting ovulation Open
Biochemical confirmation of ovulation typically involves measuring serum progesterone levels during the mid‐luteal phase. Alternatively, this information could be obtained by monitoring urinary excretion of conjugated metabolites of ovaria…
View article: LC-MS/MS measurement of endogenous steroid hormones and phase II metabolites in blood volumetric absorptive microsampling (VAMS) for doping control purposes
LC-MS/MS measurement of endogenous steroid hormones and phase II metabolites in blood volumetric absorptive microsampling (VAMS) for doping control purposes Open
The validated LC-MS/MS method demonstrated its suitability for the measurement of steroids in dried blood VAMS. The observed stability of steroidal compounds suggests promising prospects for future applications of VAMS, both in anti-doping…
View article: Metformin and the Liver: Unlocking the Full Therapeutic Potential
Metformin and the Liver: Unlocking the Full Therapeutic Potential Open
Metformin is a highly effective medication for managing type 2 diabetes mellitus. Recent studies have shown that it has significant therapeutic benefits in various organ systems, particularly the liver. Although the effects of metformin on…
View article: Unlocking the Power of Late-Evening Snacks: Practical Ready-to-Prescribe Chart Menu for Patients with Cirrhosis
Unlocking the Power of Late-Evening Snacks: Practical Ready-to-Prescribe Chart Menu for Patients with Cirrhosis Open
The efficacy of the late-evening snack (LES) has been extensively studied due to the impact of the longest intermeal duration occurring at night in patients with cirrhosis. While actual clinical guidelines on nutrition in chronic liver dis…
View article: From Listing to Recovery: A Review of Nutritional Status Assessment and Management in Liver Transplant Patients
From Listing to Recovery: A Review of Nutritional Status Assessment and Management in Liver Transplant Patients Open
Liver transplantation (LT) is a complex surgical procedure requiring thorough pre- and post-operative planning and care. The nutritional status of the patient before, during, and after LT is crucial to surgical success and long-term progno…
View article: Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group
Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group Open
Background: Urinary tract infection (UTI) represents one of the most common infectious diseases and a major cause of antibiotic prescription in children. To prevent recurrent infections and long-term complications, low-dose continuous anti…
View article: Osteosarcopenia in NAFLD/MAFLD: An Underappreciated Clinical Problem in Chronic Liver Disease
Osteosarcopenia in NAFLD/MAFLD: An Underappreciated Clinical Problem in Chronic Liver Disease Open
Chronic liver disease (CLD), including non-alcoholic fatty liver disease (NAFLD) and its advanced form, non-alcoholic steatohepatitis (NASH), affects a significant portion of the population worldwide. NAFLD is characterised by fat accumula…
View article: Creatine Supplementation to Improve Sarcopenia in Chronic Liver Disease: Facts and Perspectives
Creatine Supplementation to Improve Sarcopenia in Chronic Liver Disease: Facts and Perspectives Open
Creatine supplementation has been one of the most studied and useful ergogenic nutritional support for athletes to improve performance, strength, and muscular mass. Over time creatine has shown beneficial effects in several human disease c…
View article: Zebrafish Tric-b is required for skeletal development and bone cells differentiation
Zebrafish Tric-b is required for skeletal development and bone cells differentiation Open
Introduction Trimeric intracellular potassium channels TRIC-A and -B are endoplasmic reticulum (ER) integral membrane proteins, involved in the regulation of calcium release mediated by ryanodine (RyRs) and inositol 1,4,5-trisphosphate (IP…
View article: Zebrafish tmem38b Knock out unveils the in vivo role of Trimeric Intracellular Cation (TRIC) channel B on cell homeostasis
Zebrafish tmem38b Knock out unveils the in vivo role of Trimeric Intracellular Cation (TRIC) channel B on cell homeostasis Open
View article: 649 Clinicians miss diagnosis: it wasn’t a tako-tsubo syndrome, nowadays it is a recurrent tako-tsubo syndrome
649 Clinicians miss diagnosis: it wasn’t a tako-tsubo syndrome, nowadays it is a recurrent tako-tsubo syndrome Open
Aims Tako-Tsubo syndrome is an usual form of acute cardiomyopathy characterized by reversible left ventricle apical ballooning which occurs in the absence of significant coronary artery disease. Rarely an increase in catecholamines due to …
View article: Knocking out TMEM38B in human foetal osteoblasts hFOB 1.19 by CRISPR/Cas9: A model for recessive OI type XIV
Knocking out TMEM38B in human foetal osteoblasts hFOB 1.19 by CRISPR/Cas9: A model for recessive OI type XIV Open
Osteogenesis imperfecta (OI) type XIV is a rare recessive bone disorder characterized by variable degree of severity associated to osteopenia. It is caused by mutations in TMEM38B encoding for the trimeric intracellular cation channel TRIC…
View article: Knock out of tmem38b by CRISPR/Cas9 in zebrafish unveils the in vivo role of Trimeric intracellular cation (TRIC) channel B on cell homeostasis
Knock out of tmem38b by CRISPR/Cas9 in zebrafish unveils the in vivo role of Trimeric intracellular cation (TRIC) channel B on cell homeostasis Open
View article: Malnutrition and nutritional therapy in patients with SARS-CoV-2 disease
Malnutrition and nutritional therapy in patients with SARS-CoV-2 disease Open
View article: Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders
Zebrafish: A Resourceful Vertebrate Model to Investigate Skeletal Disorders Open
Animal models are essential tools for addressing fundamental scientific questions about skeletal diseases and for the development of new therapeutic approaches. Traditionally, mice have been the most common model organism in biomedical res…
View article: Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate
Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate Open
Osteogenesis imperfecta (OI) types VII, VIII and IX, caused by recessive mutations in cartilage-associated protein (CRTAP), prolyl-3-hydroxylase 1 (P3H1) and cyclophilin B (PPIB), respectively, are characterized by the synthesis of overmod…
View article: A comparison of pituitary function in primary and secondary empty sella: preliminary data
A comparison of pituitary function in primary and secondary empty sella: preliminary data Open
Background Empty sella (ES), the herniation of the subarachnoid space within sella associated with a variable flattening of the pituitary gland, is classified as primary (PES) or secondary (SES) on the basis of etiological factors. Aim To …