Laura López‐Cruz
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View article: Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening
Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening Open
Rationale A major obstacle in the pre-clinical study of mood-related disorders and novel affective state therapeutic evaluation is the lack of animal models that fully recapitulate human symptomatology. Objective In this study, we develope…
View article: Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber
Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber Open
View article: Approaches to engaging faith communities in public health efforts regarding vaccination, genetics, and colorectal cancer: a systematic review
Approaches to engaging faith communities in public health efforts regarding vaccination, genetics, and colorectal cancer: a systematic review Open
The protocol is registered on Open Science Framework (OSF) at osf.io/r2c9n.
View article: Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: Relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens
Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: Relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens Open
Mesolimbic dopamine (DA) plays a critical role in behavioral activation and exertion of effort in motivated behaviors. DA antagonism and depletion in nucleus accumbens (Nacb) induces anergia in effort-based decision-making tasks. Exercise …
View article: Developmental origin of oligodendrocytes determines their function in the adult brain
Developmental origin of oligodendrocytes determines their function in the adult brain Open
View article: Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice Open
View article: Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task
Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task Open
Effort-based decision-making is impaired in multiple psychopathologies leading to significant impacts on the daily life of patients. Preclinical studies of this important transdiagnostic symptom in rodents are hampered, however, by limitat…
View article: Reconsidering Repurposing: Long-term metformin treatment impairs cognition in Alzheimer’s model mice
Reconsidering Repurposing: Long-term metformin treatment impairs cognition in Alzheimer’s model mice Open
Metformin, a first-line anti-diabetic medication, may provide benefits against the pathogenesis of Alzheimer’s disease (AD) or “type 3 diabetes”. However, studies have demonstrated that metformin treatment may increase the risk of AD and a…
View article: Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress
Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress Open
View article: Sex-dependent effects of early life stress on reinforcement learning and limbic cortico-striatal functional connectivity
Sex-dependent effects of early life stress on reinforcement learning and limbic cortico-striatal functional connectivity Open
View article: Early-life stress biases responding to negatively valenced stimuli and increases amygdala volume and vulnerability to later-life stress
Early-life stress biases responding to negatively valenced stimuli and increases amygdala volume and vulnerability to later-life stress Open
Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental and physical health outcomes in adulthood. However, whether these relationships are mediated by the consequences …
View article: Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion
Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion Open
Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. …
View article: Impact of Caffeine on Ethanol‐Induced Stimulation and Sensitization: Changes in ERK and DARPP‐32 Phosphorylation in Nucleus Accumbens
Impact of Caffeine on Ethanol‐Induced Stimulation and Sensitization: Changes in ERK and DARPP‐32 Phosphorylation in Nucleus Accumbens Open
Background Caffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)‐related markers in accumbens (Acb), and Acb DA i…
View article: Bupropion Increases Selection of High Effort Activity in Rats Tested on a Progressive Ratio/Chow Feeding Choice Procedure: Implications for Treatment of Effort-Related Motivational Symptoms
Bupropion Increases Selection of High Effort Activity in Rats Tested on a Progressive Ratio/Chow Feeding Choice Procedure: Implications for Treatment of Effort-Related Motivational Symptoms Open
Background:Depression and related disorders are characterized by deficits in behavioral activation, exertion of effort, and other psychomotor/motivational dysfunctions. Depressed patients show alterations in effort-related decision making …
View article: Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS–FTD
Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS–FTD Open
View article: Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia Open
Physical activities can have intrinsic motivational or reinforcing properties. The choice to engage in voluntary physical activity is undertaken in relation to the selection of other alternatives, such as sedentary behaviors, drugs, or foo…
View article: Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence Open
View article: Translational tests involving non-reward: methodological considerations
Translational tests involving non-reward: methodological considerations Open
View article: Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion
Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion Open
Caffeine is a methylxanthine consumed in different contexts to potentiate alertness and reduce fatigue. However, caffeine can induce anxiety at high doses. Caffeine is also a minor psychostimulant that seems to act as an appetite suppressa…
View article: Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression Open
Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional tr…
View article: Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures
Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures Open
View article: Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors
Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors Open
Ethanol and caffeine are frequently consumed in combination and have opposite effects on the adenosine system: ethanol metabolism leads to an increase in adenosine levels, while caffeine is a non-selective adenosine A1/A2A<…
View article: Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology Open
Motivation has been defined as the process that allows organisms to regulate their internal and external environment, and control the probability, proximity and availability of stimuli. As such, motivation is a complex process that is crit…
View article: SY02-4IMPACT OF DOPAMINE DEPLETION OR ENHANCEMENT ON ETHANOL CONSUMPTION IN RATS: FREE VERSUS WORK-MEDIATED ACCESS
SY02-4IMPACT OF DOPAMINE DEPLETION OR ENHANCEMENT ON ETHANOL CONSUMPTION IN RATS: FREE VERSUS WORK-MEDIATED ACCESS Open
Nucleus accumbens dopamine (DA) plays a critical role in behavioral activation and effort-based decision-making.DA depletions reduce the level of effort that an animal is willing to make to obtain a natural reinforcer, but it does not chan…
View article: El ejercicio forzado previene la anergia inducida por la depleción de dopamina. Estudios comparando la selección entre actividad física o la ingesta de alimentos dulces
El ejercicio forzado previene la anergia inducida por la depleción de dopamina. Estudios comparando la selección entre actividad física o la ingesta de alimentos dulces Open
Disfunciones relacionadas con el esfuerzo como la anergia y la fatiga son síntomas centrales
\nde la depresión y otros trastornos. El sistema dopaminérgico (DA) mesolímbico
\ndesempeña un papel crítico en la activación de la conducta. Sin …
View article: Dosis medias y altas de cafeína no revierten la incoordinación motora producida por alcohol en ratones
Dosis medias y altas de cafeína no revierten la incoordinación motora producida por alcohol en ratones Open
En los últimos años, el consumo de las bebidas energéticas ha incrementado notablemente,
\nasí como su concentración de cafeína. Con frecuencia, estas bebidas se consumen
\njunto a grandes cantidades de alcohol con el objetivo de reducir l…
View article: Interacción entre receptores d2 y a2a. Toma de decisiones basada en el esfuerzo mediante un Programa de Razón Progresiva en rat
Interacción entre receptores d2 y a2a. Toma de decisiones basada en el esfuerzo mediante un Programa de Razón Progresiva en rat Open
Uno de los síntomas motivacionales característicos de la depresión y que supone un
\nmayor problema para la realización de tareas cotidianas, es la anergia. Este síntoma
\nsupone una disminución del vigor y el esfuerzo que el sujeto está d…