Laura Loy
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View article: Rate of Participation in a Second Randomized Clinical Trial and Factors Associated with the Likelihood of Participation among IBD Patients who already Experienced a Randomized Clinical Trial.
Rate of Participation in a Second Randomized Clinical Trial and Factors Associated with the Likelihood of Participation among IBD Patients who already Experienced a Randomized Clinical Trial. Open
Understanding factors affecting re-participation in IBD trials is crucial to improving patient involvement in research.
View article: Acute Pancreatitis in Inflammatory Bowel Disease: Results from the European Pandora Study
Acute Pancreatitis in Inflammatory Bowel Disease: Results from the European Pandora Study Open
Background and aims: An increased risk of acute pancreatitis (AP) has been reported in patients with inflammatory bowel disease (IBD), but data on its prevalence, etiology, and outcomes are limited. Materials and Methods: A two-step retros…
View article: Ustekinumab Intravenous Reinduction after Secondary Loss of Response in Patients with Crohn’s Disease
Ustekinumab Intravenous Reinduction after Secondary Loss of Response in Patients with Crohn’s Disease Open
Background The POWER study (NCT03782376) evaluated efficacy and safety of a single ustekinumab intravenous (IV) reinduction dose versus placebo under continued ustekinumab subcutaneous (SC) treatment in adult patients with moderately to se…
View article: Drug Development in Inflammatory Bowel Diseases: What Is Next?
Drug Development in Inflammatory Bowel Diseases: What Is Next? Open
Background/Objectives: Inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic conditions requiring long-term therapy to maintain remission and improve quality of life. Despite the ap…
View article: Clinical phenotypes and therapeutic outcomes in enteropathic arthritis: a multivariate analysis from a retrospective cohort
Clinical phenotypes and therapeutic outcomes in enteropathic arthritis: a multivariate analysis from a retrospective cohort Open
The significantly higher likelihood of developing enthesitis in IBD-first suggests that distinct disease onset patterns and clinical phenotypes may influence musculoskeletal manifestations and treatment responses in enteropathic arthritis.
View article: Prevalence, Risk Factors and Association with Clinical Outcomes of Malnutrition and Sarcopenia in Inflammatory Bowel Disease: A Prospective Study
Prevalence, Risk Factors and Association with Clinical Outcomes of Malnutrition and Sarcopenia in Inflammatory Bowel Disease: A Prospective Study Open
Introduction: The prevalences of malnutrition and sarcopenia in patients with IBD are not precisely known, and nutritional assessment is not standardized. We assessed the prevalence and risk factors of these conditions in outpatients and t…
View article: Prevalence, Characteristics, Management, and Outcomes of Difficult-to-Treat Inflammatory Bowel Disease
Prevalence, Characteristics, Management, and Outcomes of Difficult-to-Treat Inflammatory Bowel Disease Open
Background and Aims Criteria for “difficult-to-treat” inflammatory bowel disease (DTT-IBD) have recently been proposed to standardize terminology. We aimed to evaluate the prevalence, characteristics, management, and outcomes of DTT-IBD. M…
View article: Dietary Fiber in Inflammatory Bowel Disease: Are We Ready to Change the Paradigm?
Dietary Fiber in Inflammatory Bowel Disease: Are We Ready to Change the Paradigm? Open
Accumulating evidence from pre-clinical and clinical studies demonstrate the benefit of dietary fibers for inflammatory bowel disease (IBD). However, the majority of patients avoid or limit their consumption to manage their symptoms during…
View article: Ophthalmological Manifestations in Inflammatory Bowel Diseases: Keep an Eye on It
Ophthalmological Manifestations in Inflammatory Bowel Diseases: Keep an Eye on It Open
Background and aims: Inflammatory bowel diseases (IBD) are multifactorial chronic inflammatory disorders affecting the gastrointestinal tract. However, a broad spectrum of extraintestinal manifestations (EIMs) is associated with IBD, affec…
View article: P079 Low-intensity Pulsed Ultrasound reflects the status of mucosal injury and repair through stage-specific miRNAs in experimental model of Ulcerative Colitis
P079 Low-intensity Pulsed Ultrasound reflects the status of mucosal injury and repair through stage-specific miRNAs in experimental model of Ulcerative Colitis Open
Background Diagnosis and therapeutic efficacy monitoring of Ulcerative Colitis (UC) are based on a multidisciplinary approach comprising symptomatology and invasive endoscopic assessment coupled to the histopathological characterization of…
View article: P055 GPR43 and GPR84 play a crucial role in supporting perianal fistula formation and disease progression in Crohn’s Disease
P055 GPR43 and GPR84 play a crucial role in supporting perianal fistula formation and disease progression in Crohn’s Disease Open
Background Fistula complication represents one of the most disabling manifestations of Crohn’s Disease and a risk factor for more aggressive disease progression and mucinous adenocarcinoma . However, molecular mechanisms behind this transf…
View article: DOP88 Lipids drive myofibroblast activation and the epithelial-mesenchymal transition process in Crohn’s Disease
DOP88 Lipids drive myofibroblast activation and the epithelial-mesenchymal transition process in Crohn’s Disease Open
Background Fibrostenosis represents one of the major clinical complications of Crohn’s Disease (CD). However, the molecular mechanisms underlying intestinal fibrogenesis remain poorly understood and anti-fibrotic therapy has not yet been d…
View article: Pomegranate Extract Affects Gut Biofilm Forming Bacteria and Promotes Intestinal Mucosal Healing Regulating the Crosstalk between Epithelial Cells and Intestinal Fibroblasts
Pomegranate Extract Affects Gut Biofilm Forming Bacteria and Promotes Intestinal Mucosal Healing Regulating the Crosstalk between Epithelial Cells and Intestinal Fibroblasts Open
Background: Pomegranate (Punica granatum) can be used to prepare a bioactive extract exerting anti-inflammatory activities. Clinical studies demonstrated an improvement in clinical response in inflammatory bowel disease (IBD) patients when…
View article: P092 Punica Granatum affects gut biofilm-forming bacteria and promotes intestinal mucosal healing regulating the crosstalk between epithelial cells and intestinal fibroblasts
P092 Punica Granatum affects gut biofilm-forming bacteria and promotes intestinal mucosal healing regulating the crosstalk between epithelial cells and intestinal fibroblasts Open
Background Punica Granatum (PG), is a bioactive compound of Pomegranate exerting anti-inflammatory activities. Clinical studies have demonstrated an improvement of clinical response in inflammatory bowel diseases (IBD) patients when PG was…
View article: P442 Endoscopic resection of visible precancerous lesions in patients with colonic Inflammatory Bowel Disease
P442 Endoscopic resection of visible precancerous lesions in patients with colonic Inflammatory Bowel Disease Open
Background IBD patients have an increased risk of reporting a colorectal cancer. According to SCENIC, endoscopic resection (ER) should be preferred to biopsies for visible precancerous lesions in absence of stigmata of invasive cancer or s…
View article: P117 Low-Intensity Pulsed Ultrasound as a new approach of gut disruptive liquid biopsy to boost the release of mucosal extracellular vesicles in Ulcerative Colitis
P117 Low-Intensity Pulsed Ultrasound as a new approach of gut disruptive liquid biopsy to boost the release of mucosal extracellular vesicles in Ulcerative Colitis Open
Background Ulcerative Colitis (UC) is a chronic, idiopathic intestinal inflammatory disease whose diagnosis requires colonoscopy with biopsy. There is an unmet need for sensitive, and easy-to-detect biomarkers helping a rapid and non-invas…
View article: Viral infections in inflammatory bowel disease: Tips and tricks for correct management
Viral infections in inflammatory bowel disease: Tips and tricks for correct management Open
Over the past decades, the treatment of inflammatory bowel diseases (IBD) has become more targeted, anticipating the use of immune-modifying therapies at an earlier stage. This top-down approach has been correlated with favorable short and…
View article: Rediscovering histology: what is new in endoscopy for inflammatory bowel disease?
Rediscovering histology: what is new in endoscopy for inflammatory bowel disease? Open
The potential of endoscopic evaluation in the management of inflammatory bowel diseases (IBD) has undoubtedly grown over the last few years. When dealing with IBD patients, histological remission (HR) is now considered a desirable target a…
View article: Patients' perspectives on smoking and inflammatory bowel disease: An online survey in collaboration with European Federation of Crohn's and Ulcerative Colitis Associations
Patients' perspectives on smoking and inflammatory bowel disease: An online survey in collaboration with European Federation of Crohn's and Ulcerative Colitis Associations Open
This survey found significant differences between CD and UC patients in both awareness and perception of the impact of smoking on their disease. Further efforts should be done to encourage smoking cessation for all IBD patients, including …
View article: P747 Adherence to ECCO guidelines for cancer surveillance is associated to the detection of early cancer: A retrospective, single-centre, cohort study
P747 Adherence to ECCO guidelines for cancer surveillance is associated to the detection of early cancer: A retrospective, single-centre, cohort study Open
Background Patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD) are at increased risk of developing gastrointestinal (GI) malignancies. The aim of this study is to assess the risk of mali…
View article: DOP63 Efficacy and safety of iron carboxymaltose on chronic fatigue in patients with inflammatory bowel disease: a randomised controlled trial
DOP63 Efficacy and safety of iron carboxymaltose on chronic fatigue in patients with inflammatory bowel disease: a randomised controlled trial Open
Background Patients with inflammatory bowel diseases (IBD) have an altered quality of life, also due to chronic fatigue (CF). Iron administration is effective in iron deficiency associated with CF in patients with heart failure. Our hypoth…