Laura M. Beaver
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View article: Protective role of dietary zinc on DNA damage, oxidative stress, and metal toxicity
Protective role of dietary zinc on DNA damage, oxidative stress, and metal toxicity Open
Dr. Bruce Ames illustrious career spanned many decades with far-reaching impacts both on our knowledge of DNA and in public health. In the 1990s he explored the connection between inadequate intake of micronutrients and single- and double-…
View article: Combinatorial Effects of Zinc Status and Aging on Bone in Male Mice
Combinatorial Effects of Zinc Status and Aging on Bone in Male Mice Open
View article: Beneficial Changes in Total and LDL-Cholesterol, Gut Health Parameters, and Vitamin E Status in Adults With Metabolic Syndrome Consuming Almonds as Snacks
Beneficial Changes in Total and LDL-Cholesterol, Gut Health Parameters, and Vitamin E Status in Adults With Metabolic Syndrome Consuming Almonds as Snacks Open
View article: Promotion of Healthy Aging Through the Nexus of Gut Microbiota and Dietary Phytochemicals
Promotion of Healthy Aging Through the Nexus of Gut Microbiota and Dietary Phytochemicals Open
Aging is associated with the decline of tissue and cellular functions, which can promote the development of age-related diseases like cancer, cardiovascular disease, neurodegeneration, and disorders of the musculoskeletal and immune system…
View article: Identification of biological signatures of cruciferous vegetable consumption utilizing machine learning-based global untargeted stable isotope traced metabolomics
Identification of biological signatures of cruciferous vegetable consumption utilizing machine learning-based global untargeted stable isotope traced metabolomics Open
In recent years there has been increased interest in identifying biological signatures of food consumption for use as biomarkers. Traditional metabolomics-based biomarker discovery approaches rely on multivariate statistics which cannot di…
View article: Combinatorial Effects of Zinc Deficiency and Arsenic Exposure on Bone in Growing Female Mice
Combinatorial Effects of Zinc Deficiency and Arsenic Exposure on Bone in Growing Female Mice Open
View article: Beneficial Changes in Vitamin E Status and LDL Levels in Adults With Metabolic Syndrome Consuming Almonds as Snack Foods
Beneficial Changes in Vitamin E Status and LDL Levels in Adults With Metabolic Syndrome Consuming Almonds as Snack Foods Open
View article: Sulforaphane and Sulforaphane‐Nitrile Metabolism in Humans Following Broccoli Sprout Consumption: Inter‐individual Variation, Association with Gut Microbiome Composition, and Differential Bioactivity
Sulforaphane and Sulforaphane‐Nitrile Metabolism in Humans Following Broccoli Sprout Consumption: Inter‐individual Variation, Association with Gut Microbiome Composition, and Differential Bioactivity Open
Scope The glucosinolate glucoraphanin from broccoli is converted to sulforaphane (SFN) or sulforaphane‐nitrile (SFN‐NIT) by plant enzymes or the gut microbiome. Human feeding studies typically observe high inter‐individual variation in abs…
View article: Sulforaphane Bioavailability in Healthy Subjects Fed a Single Serving of Fresh Broccoli Microgreens
Sulforaphane Bioavailability in Healthy Subjects Fed a Single Serving of Fresh Broccoli Microgreens Open
Cruciferous vegetable consumption is associated with numerous health benefits attributed to the phytochemical sulforaphane (SFN) that exerts antioxidant and chemopreventive properties, among other bioactive compounds. Broccoli sprouts, ric…
View article: OR15-03-23 Discovery of Novel Metabolomic Signatures Following the Consumption of Broccoli Sprouts Using Untargeted Metabolomics
OR15-03-23 Discovery of Novel Metabolomic Signatures Following the Consumption of Broccoli Sprouts Using Untargeted Metabolomics Open
View article: P31-007-23 Diet Composition Influences the Effect of High Fat Diets on Bone in Growing Male Mice
P31-007-23 Diet Composition Influences the Effect of High Fat Diets on Bone in Growing Male Mice Open
View article: Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
There continues to be interest in targeting epigenetic “readers, writers, and erasers” for the treatment of cancer and other pathologies. However, a mechanistic understanding is frequently lacking for the synergy observed when combining de…
View article: Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
There continues to be interest in targeting epigenetic “readers, writers, and erasers” for the treatment of cancer and other pathologies. However, a mechanistic understanding is frequently lacking for the synergy observed when combining de…
View article: Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
Fig S1 shows HDAC3 knockdown, Fig S2 shows CCAR2 acetylation in SW480 colon cancer cells. Fig S3 shows mass spectrometry data, Fig S4 shows acetylation mutant data, Fig S5 shows a Working model, Fig S6 shows genetically encoded acetylation…
View article: Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition
Supplementary Data from Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition Open
Fig S1 shows HDAC3 knockdown, Fig S2 shows CCAR2 acetylation in SW480 colon cancer cells. Fig S3 shows mass spectrometry data, Fig S4 shows acetylation mutant data, Fig S5 shows a Working model, Fig S6 shows genetically encoded acetylation…
View article: Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach
Interplay between Cruciferous Vegetables and the Gut Microbiome: A Multi-Omic Approach Open
Brassica vegetables contain a multitude of bioactive compounds that prevent and suppress cancer and promote health. Evidence suggests that the gut microbiome may be essential in the production of these compounds; however, the relationship …
View article: Nitrate exposure reprograms hepatic amino acid and nutrient sensing pathways prior to exercise: A metabolomic and transcriptomic investigation in zebrafish (Danio rerio)
Nitrate exposure reprograms hepatic amino acid and nutrient sensing pathways prior to exercise: A metabolomic and transcriptomic investigation in zebrafish (Danio rerio) Open
Scope: Nitrate supplementation is a popular ergogenic aid that improves exercise performance by reducing oxygen consumption during exercise. We investigated the effect of nitrate exposure and exercise on metabolic pathways in zebrafish liv…
View article: Metabolic Fate of Dietary Glucosinolates and Their Metabolites: A Role for the Microbiome
Metabolic Fate of Dietary Glucosinolates and Their Metabolites: A Role for the Microbiome Open
Robust evidence shows that phytochemicals from cruciferous vegetables, like broccoli, are associated with numerous health benefits. The anti-cancer properties of these foods are attributed to bioactive isothiocyanates (ITCs) and indoles, p…
View article: Composition of the Gut Microbiome Influences Production of Sulforaphane-Nitrile and Iberin-Nitrile from Glucosinolates in Broccoli Sprouts
Composition of the Gut Microbiome Influences Production of Sulforaphane-Nitrile and Iberin-Nitrile from Glucosinolates in Broccoli Sprouts Open
Isothiocyanates, such as sulforaphane and iberin, derived from glucosinolates (GLS) in cruciferous vegetables, are known to prevent and suppress cancer development. GLS can also be converted by bacteria to biologically inert nitriles, such…
View article: Dietary Nitrate Supplementation Alters Protein and Lipid Metabolism in Zebrafish (Danio rerio) Livers
Dietary Nitrate Supplementation Alters Protein and Lipid Metabolism in Zebrafish (Danio rerio) Livers Open
OBJECTIVES: Dietary nitrate supplementation shows protective effects against cardio-metabolic disease, decreases pulmonary oxygen uptake, and improves exercise performance in animal models and humans. However, the biological effect of nitr…
View article: Nitrate-Induced Improvements in Exercise Performance Is Coincident With Exuberant Changes in Metabolic Genes and the Metabolome in Zebrafish (Danio rerio) Skeletal Muscle
Nitrate-Induced Improvements in Exercise Performance Is Coincident With Exuberant Changes in Metabolic Genes and the Metabolome in Zebrafish (Danio rerio) Skeletal Muscle Open
View article: Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish (<i>Danio rerio</i>) skeletal muscle
Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish (<i>Danio rerio</i>) skeletal muscle Open
We show that skeletal muscle nitrate concentration is higher with supplementation at rest and was lower in groups with increasing exercise duration in a zebrafish model. The higher availability of nitrate at rest is associated with upregul…
View article: Supplemental Table S5
Supplemental Table S5 Open
This data table shows the statistical output for a 2-way ANOVA using Metaboanalyst for both 1H-NMR spectroscopy and LC-MS/MS data from the study.
View article: Supplemental Table S1.pdf
Supplemental Table S1.pdf Open
This table is a list of the zebrafish genes and primer sequences for each gene used in the quantitative PCR analysis conducted in this study to determine gene expression.
View article: Supplemental Table S3
Supplemental Table S3 Open
This data table shows concentration of all identified metabolites using 1H-NMR spectroscopy from zebrafish muscle.
View article: Supplemental Table S6
Supplemental Table S6 Open
This data tables shows the multiple comparisons for each metabolite and includes the T statistic (t.stat), P value (p.value), FDR, fold change and log2(FC). All comparisons were done using MetaboAnalyst 5.0.
View article: Supplemental Table S2
Supplemental Table S2 Open
This table is shows all annotated features using LC-MS/MS- and 1H-NMR- based metabolomics analysis.
View article: Supplemental Table S4
Supplemental Table S4 Open
This data table shows the relative abundance of each annotated metabolite analyzed using LC/MS-MS.
View article: Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish
Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish Open
Dietary nitrate lowers blood pressure and improves athletic performance in humans, yet data supporting observations that it may increase cerebral blood flow and improve cognitive performance are mixed. We tested the hypothesis that nitrate…
View article: An integrated gene catalog of the zebrafish gut microbiome reveals significant homology with mammalian microbiomes
An integrated gene catalog of the zebrafish gut microbiome reveals significant homology with mammalian microbiomes Open
Gut microbiome research increasingly utilizes zebrafish ( Danio rerio ) given their amenability to high-throughput experimental designs. However, the utility of zebrafish for discerning translationally relevant host-microbiome interactions…