Laura M. Dember
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View article: Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies
Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies Open
More than 50% of patients with kidney failure undergoing maintenance hemodialysis die within 5 years, a fate unexplained by traditional risk factors. To identify biological risk factors, we analyze 6287 circulating proteins and mortality i…
View article: Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study
Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study Open
Little is known about the prognostic value of continuous, out-of-clinic biometric monitoring of cardiovascular function in chronic kidney disease (CKD). In this study, a mean (±SD) of 50.3 ± 9.3 h of EKG recordings from wearable BioPatch d…
View article: Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease
Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease Open
Individuals with CKD and elevated Lp(a) without clinical CVD may derive net benefit from low-dose aspirin for the primary prevention of MI and ESRD.
View article: Disentangling informing participants from obtaining their consent
Disentangling informing participants from obtaining their consent Open
Introduction Pragmatic clinical trials conducted in the context of routine care frequently satisfy the regulatory criteria for a waiver of research consent. When they do, investigators and Institutional Review Boards might assume that ther…
View article: Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula
Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula Open
The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations of wall shear stress (WSS) with subsequent AVF remodeling and clinical maturation using regression models in this prospective coho…
View article: Cultivating Innovative, Pragmatic, Randomized Controlled Registry Trials Embedded in Hemodialysis Care: Conference Proceeding From Gardener’s Grove 2023
Cultivating Innovative, Pragmatic, Randomized Controlled Registry Trials Embedded in Hemodialysis Care: Conference Proceeding From Gardener’s Grove 2023 Open
Purpose of the Conference: Hemodialysis is a life-sustaining treatment for patients with end-stage kidney disease. However, patients on dialysis continue to face poor quality of life and short life expectancies. Despite this, the nephrolog…
View article: Pain Coping Skills Training for Patients Receiving Hemodialysis
Pain Coping Skills Training for Patients Receiving Hemodialysis Open
Importance Chronic pain is common among individuals with dialysis-dependent kidney failure. Objective To evaluate the effectiveness of pain coping skills training (PCST), a cognitive behavioral intervention, on pain interference. Design, S…
View article: Heart failure events in randomized controlled trials for adults receiving maintenance dialysis: a meta-epidemiologic study
Heart failure events in randomized controlled trials for adults receiving maintenance dialysis: a meta-epidemiologic study Open
Background and hypothesis Heart failure is characterized as cardiac dysfunction resulting in elevated cardiac filling pressures with symptoms and signs of congestion. Distinguishing heart failure from other causes of similar presentations …
View article: Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study
Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study Open
View article: Comparative CKD risk prediction using homocitrulline and carbamylated albumin: two circulating markers of protein carbamylation
Comparative CKD risk prediction using homocitrulline and carbamylated albumin: two circulating markers of protein carbamylation Open
Background Protein carbamylation, a post-translational protein modification primarily driven by urea, independently associates with adverse clinical outcomes in patients with CKD. Biomarkers used to quantify carbamylation burden have mainl…
View article: Five‐Year Cumulative Cardiovascular Health and Clinical Events in Patients With Chronic Kidney Disease: The CRIC Study
Five‐Year Cumulative Cardiovascular Health and Clinical Events in Patients With Chronic Kidney Disease: The CRIC Study Open
Background Higher cardiovascular health (CVH) score is associated with lower risks of cardiovascular disease (CVD) and mortality in the general population. However, it is unclear whether cumulative CVH is associated with CVD, end‐stage kid…
View article: Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials
Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials Open
View article: Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Open
View article: The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis
The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis Open
View article: Factors Associated With Non-vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
Factors Associated With Non-vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Open
View article: Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts
Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts Open
View article: Performance Characteristics of Candidate Criteria for Hemodialysis Arteriovenous Fistula Maturation
Performance Characteristics of Candidate Criteria for Hemodialysis Arteriovenous Fistula Maturation Open
Background Twenty to 60% of newly created hemodialysis arteriovenous fistulas do not mature adequately for use. One barrier to developing interventions to improve fistula outcomes is a lack of standardized criteria for maturation. Methods …
View article: Contrast Venography Versus Intravenous Ultrasound in Hemodialysis Arteriovenous Access Dysfunction
Contrast Venography Versus Intravenous Ultrasound in Hemodialysis Arteriovenous Access Dysfunction Open
View article: Managing the symptom burden associated with maintenance dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Managing the symptom burden associated with maintenance dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Open
View article: Evaluation of the effect of sodium zirconium cyclosilicate on arrhythmia-related cardiovascular outcomes in patients receiving chronic haemodialysis with hyperkalaemia: protocol for the multicentre, randomised, controlled DIALIZE-Outcomes study
Evaluation of the effect of sodium zirconium cyclosilicate on arrhythmia-related cardiovascular outcomes in patients receiving chronic haemodialysis with hyperkalaemia: protocol for the multicentre, randomised, controlled DIALIZE-Outcomes study Open
Introduction Patients with kidney failure receiving chronic haemodialysis have elevated risk of arrhythmias potentially increasing the likelihood of sudden cardiac death, stroke and hospitalisation. The DIALIZE study ( NCT03303521 ) demons…
View article: Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting.
Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting. Open
Acute kidney injury (AKI) is a growing epidemic and is independently associated with increased risk of death, chronic kidney disease (CKD) and cardiovascular events. Randomized-controlled trials (RCTs) in this domain are notoriously challe…
View article: Dynamics of Plasma Refill Rate and Intradialytic Hypotension During Hemodialysis: Retrospective Cohort Study With Causal Methodology
Dynamics of Plasma Refill Rate and Intradialytic Hypotension During Hemodialysis: Retrospective Cohort Study With Causal Methodology Open
Key Points Directly studying plasma refill rate (PRR) during hemodialysis (HD) can offer insight into physiologic mechanisms that change throughout HD. PRR at the start and during HD is associated with intradialytic hypotension, independen…
View article: Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial
Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial Open
Key Points The effects of spironolactone on arrhythmia in patients receiving maintenance hemodialysis are unclear. In these post hoc analyses, spironolactone resulted in a higher frequency of bradycardia and conduction blocks, compared wit…
View article: Response to “Use of Oral Furosemide in Hemodialysis”
Response to “Use of Oral Furosemide in Hemodialysis” Open
View article: Association between anaesthesia type and arteriovenous fistula maturation
Association between anaesthesia type and arteriovenous fistula maturation Open
View article: The Potential for Pragmatic Trials to Reduce Racial and Ethnic Disparities in Kidney Disease
The Potential for Pragmatic Trials to Reduce Racial and Ethnic Disparities in Kidney Disease Open
The well-documented and unacceptable racial and ethnic disparities in the prevalence and outcomes of kidney disease are receiving increased attention within and beyond the nephrology community, with numerous calls for intentional, active a…
View article: A randomized controlled pilot trial of anakinra for hemodialysis inflammation
A randomized controlled pilot trial of anakinra for hemodialysis inflammation Open
Chronic inflammation is highly prevalent among patients receiving maintenance hemodialysis and is associated with morbidity and mortality. Inhibiting inflammation with anti-cytokine therapy has been proposed but not well studied in this po…
View article: Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study
Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study Open
Furosemide was generally safe and well tolerated, but only one-third of participants met the efficacy definition at week 5. The clinical importance of the efficacy findings is uncertain.
View article: Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation
Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation Open
The nonmaturation rate of arteriovenous fistulas (AVFs) is high.1 The direct connection of the AVF vein and artery creates a short path that bypasses the distal high-resistance vasculature, resulting in an immediate increase in the flow ra…
View article: Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting
Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting Open
Acute kidney injury (AKI) is a growing epidemic and is independently associated with increased risk of death, chronic kidney disease (CKD) and cardiovascular events. Randomized-controlled trials (RCTs) in this domain are notoriously challe…