Laura M. Szczesniak
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View article: Functional characterization of <i>Ixodes</i> neuropeptide receptors
Functional characterization of <i>Ixodes</i> neuropeptide receptors Open
Neuropeptidergic systems control feeding behaviors in animals, including arthropods. Given the wide variety of pathogens transmitted by ticks during hematophagy, there is an urgency to understand the neural mechanisms responsible for tick …
View article: Low-dose overlap initiation with split tablets of buprenorphine in intubated intensive care unit patients with opioid use disorder
Low-dose overlap initiation with split tablets of buprenorphine in intubated intensive care unit patients with opioid use disorder Open
Background As the opioid public health crisis evolves to include fentanyl and other potent synthetic opioids, more patients are admitted to the hospital with serious complications of drug use and frequently require higher levels of care, i…
View article: Endogenous Bok is stable at the endoplasmic reticulum membrane and does not mediate proteasome inhibitor-induced apoptosis
Endogenous Bok is stable at the endoplasmic reticulum membrane and does not mediate proteasome inhibitor-induced apoptosis Open
Controversy surrounds the cellular role of the Bcl-2 family protein Bok. On one hand, it has been shown that all endogenous Bok is bound to inositol 1,4,5-trisphosphate receptors (IP 3 Rs), while other data suggest that Bok can act as a pr…
View article: Identification of the Bok Interactome Using Proximity Labeling
Identification of the Bok Interactome Using Proximity Labeling Open
The function of the Bcl-2 family member Bok is currently enigmatic, with various disparate roles reported, including mediation of apoptosis, regulation of mitochondrial morphology, binding to inositol 1,4,5-trisphosphate receptors, and reg…
View article: Bridge clinic buprenorphine program decreases emergency department visits
Bridge clinic buprenorphine program decreases emergency department visits Open
These early results suggest that prompt referral to a buprenorphine treatment program significantly reduces ED utilization and connects patients to community resources for continued buprenorphine treatment for OUD.
View article: Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptor
Bok binds to a largely disordered loop in the coupling domain of type 1 inositol 1,4,5-trisphosphate receptor Open
View article: Buprenorphine therapy in the setting of induced opioid withdrawal from oral naltrexone: a case report
Buprenorphine therapy in the setting of induced opioid withdrawal from oral naltrexone: a case report Open
Background Patients with opioid use disorder (OUD) frequently present to the emergency department for acute treatment of overdose and withdrawal. Case presentation A 29-year-old male presented to the emergency room after intravenous heroin…
View article: Bok regulates mitochondrial fusion and morphology
Bok regulates mitochondrial fusion and morphology Open
View article: The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors
The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors Open
Bok is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway, although the role that Bok plays in this pathway is unclear. We have shown previously in cultured cell lines that Bok interacts strongly with inosito…
View article: “Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H<sub>2</sub>S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model
“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H<sub>2</sub>S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model Open
The gaseous neuromodulator H2S is associated with neuronal cell death pursuant to cerebral ischemia. As cystathionine β-synthase (CBS) is the primary mediator of H2S biogenesis in the brain, it has emerged as a potential target for the tre…