Laura Mählmann
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View article: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial Open
We recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people with depression. Here we further elucidated the biological modes of action underlying the ben…
View article: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial Open
We recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people with depression. Here we further elucidated the biological modes of action underlying the ben…
View article: Melanoma and microbiota: Current understanding and future directions
Melanoma and microbiota: Current understanding and future directions Open
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various mechanisms by which intestinal bacteria ac…
View article: Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: a secondary analysis of a randomized controlled trial
Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: a secondary analysis of a randomized controlled trial Open
Background: In major depressive disorder (MDD), cognitive dysfunctions strongly contribute to functional impairments but are barely addressed in current therapies. Novel treatment strategies addressing cognitive symptoms in depression are …
View article: Effects of a probiotic add-on treatment on fronto-limbic brain structure, function, and perfusion in depression: Secondary neuroimaging findings of a randomized controlled trial
Effects of a probiotic add-on treatment on fronto-limbic brain structure, function, and perfusion in depression: Secondary neuroimaging findings of a randomized controlled trial Open
Probiotic supplementation is suggested to prevent neuronal degeneration along the uncinate fasciculus and alter fronto-limbic rsFC, effects that are partly related to the improvement of depressive symptoms. Elucidating the neural mechanism…
View article: Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial
Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial Open
A promising new treatment approach for major depressive disorder (MDD) targets the microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions affected in MDD. This is the first randomized controlled trial to…
View article: Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report
Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report Open
Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present t…
View article: Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis
Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis Open
Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric …
View article: Favorable impact of long-term exercise on disease symptoms in pediatric patients with inflammatory bowel disease
Favorable impact of long-term exercise on disease symptoms in pediatric patients with inflammatory bowel disease Open
Whereas a single bout of exercise increases albumin, erythrocytes and leukocytes, longer-term moderate-intensity exercise reduced inflammatory markers in pediatric patients with IBD. Children and teenagers with IBD should be encouraged to …
View article: Short-term probiotic augmentation in depression treatment: study protocol for a randomised controlled trial
Short-term probiotic augmentation in depression treatment: study protocol for a randomised controlled trial Open
Background There is urgent need to develop novel augmentation options for improving inadequate response to antidepressants. Emerging evidence showed that the composition of the gut microbiota is altered in patients with depression and rela…
View article: Psychological wellbeing and physical activity in children and adolescents with inflammatory bowel disease compared to healthy controls
Psychological wellbeing and physical activity in children and adolescents with inflammatory bowel disease compared to healthy controls Open
NCT NCT02264275 ; Registered 8 October 2014.
View article: The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review
The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review Open
View article: Attitudes towards personal genomics among older Swiss adults: An exploratory study
Attitudes towards personal genomics among older Swiss adults: An exploratory study Open